国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2015年
1期
48-51
,共4页
HCN1通道%学习%记忆%突触可塑性%长时程易化
HCN1通道%學習%記憶%突觸可塑性%長時程易化
HCN1통도%학습%기억%돌촉가소성%장시정역화
HCN1 channel%Learning%Memory%Synaptic plasticity%Long-term facilitation
超极化激活的环核苷酸(hyperpolarization-activated cyclic nucleotide,HCN)通道是一个非选择性离子通道家族,普遍存在于心脏和神经系统中.HCN通道家族由于其超极化激活的特性在神经系统中发挥着独特的功能.研究表明HCN通道在突触信号的传递和整合中发挥着重要的作用.随着研究的不断深入,越来越多的证据表明敲除HCN1的小鼠的运动学习能力受到损害,但空间学习能力反而增强.其机制可能是由于小脑蒲肯野细胞的HCN1的缺失,也可能是海马突触环路中某个传导通路或某个神经节点中HCN1的缺乏.
超極化激活的環覈苷痠(hyperpolarization-activated cyclic nucleotide,HCN)通道是一箇非選擇性離子通道傢族,普遍存在于心髒和神經繫統中.HCN通道傢族由于其超極化激活的特性在神經繫統中髮揮著獨特的功能.研究錶明HCN通道在突觸信號的傳遞和整閤中髮揮著重要的作用.隨著研究的不斷深入,越來越多的證據錶明敲除HCN1的小鼠的運動學習能力受到損害,但空間學習能力反而增彊.其機製可能是由于小腦蒲肯野細胞的HCN1的缺失,也可能是海馬突觸環路中某箇傳導通路或某箇神經節點中HCN1的缺乏.
초겁화격활적배핵감산(hyperpolarization-activated cyclic nucleotide,HCN)통도시일개비선택성리자통도가족,보편존재우심장화신경계통중.HCN통도가족유우기초겁화격활적특성재신경계통중발휘착독특적공능.연구표명HCN통도재돌촉신호적전체화정합중발휘착중요적작용.수착연구적불단심입,월래월다적증거표명고제HCN1적소서적운동학습능력수도손해,단공간학습능력반이증강.기궤제가능시유우소뇌포긍야세포적HCN1적결실,야가능시해마돌촉배로중모개전도통로혹모개신경절점중HCN1적결핍.
Hyperpolarization-activated cyclic nucleotide (HCN)-gated channels belong to a nonselective ion channel family,which are common in neurocyte and cardiac muscle cell.These channels play important roles in the nervous system because of their characterstics of hyperpolarization activation.Many studies have shown that HCN channels play key point in excitatory synaptic transmission and integration of output signal.With the development of research,more evidences have been found to prove that the motor learning is damaged and spatial learning ability is enhanced in HCN1 knockout mice.There are two potential mechanisms leading to these changes,one is the lack of HCN1 in cerebellum cell,and the other is the lack of HCN1 in trisynaptic circuits of hippocampus.
