中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
5期
856-858
,共3页
肿瘤乏氧%放射增敏剂%乏氧诱导因子-1α%研究进展
腫瘤乏氧%放射增敏劑%乏氧誘導因子-1α%研究進展
종류핍양%방사증민제%핍양유도인자-1α%연구진전
Tumor hypoxia%Radiosensitizers%HIF-1α%Study progress
改善肿瘤细胞的乏氧，可有效减少其对放疗的抵抗，从而提高治愈率。目前用于改善肿瘤细胞缺氧减少放射抵抗的化合物已经不仅仅局限于原有的亲电性放射增敏剂，许多具有靶向性的乏氧放射增敏剂也成为研究重点。本文在介绍肿瘤乏氧机制的基础上，对新型靶向制剂、亲电性乏氧细胞放射增敏剂、生物还原剂与植物天然提取物这四类乏氧细胞放射增敏剂的研究进展进行了综述。
改善腫瘤細胞的乏氧，可有效減少其對放療的牴抗，從而提高治愈率。目前用于改善腫瘤細胞缺氧減少放射牴抗的化閤物已經不僅僅跼限于原有的親電性放射增敏劑，許多具有靶嚮性的乏氧放射增敏劑也成為研究重點。本文在介紹腫瘤乏氧機製的基礎上，對新型靶嚮製劑、親電性乏氧細胞放射增敏劑、生物還原劑與植物天然提取物這四類乏氧細胞放射增敏劑的研究進展進行瞭綜述。
개선종류세포적핍양，가유효감소기대방료적저항，종이제고치유솔。목전용우개선종류세포결양감소방사저항적화합물이경불부부국한우원유적친전성방사증민제，허다구유파향성적핍양방사증민제야성위연구중점。본문재개소종류핍양궤제적기출상，대신형파향제제、친전성핍양세포방사증민제、생물환원제여식물천연제취물저사류핍양세포방사증민제적연구진전진행료종술。
The improvement of hypoxia of tumor cells can effectively reduce their resistance to radiation and chemotherapy and im-prove the cure rate of the tumor. Recently, the compounds which are used to improve hypoxia of tumor cells and reduce radiation resist-ance are no longer just the original electrophilic radiosensitizers, and many potential targets as radiosensitizer for hypoxia also become research focus. Based on the mechanism of tumor hypoxia, the paper summarized the study progresses in four different radiosensitizers including new targeted agents, electrophilic radiotherapy sensitization agents, biological reductants and natural plant extracts.
