中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
5期
797-798,801
,共3页
雷贝拉唑%气滞胃痛颗粒%反流性食管炎%血清胃泌素%血浆胃动素
雷貝拉唑%氣滯胃痛顆粒%反流性食管炎%血清胃泌素%血漿胃動素
뢰패랍서%기체위통과립%반류성식관염%혈청위비소%혈장위동소
Rabeprazole%Qizhi Weitong granules%Reflux esophagitis%Gastrin%Motilin
目的：：观察雷贝拉唑联合气滞胃痛颗粒治疗反流性食管炎的临床疗效及对患者血清胃泌素(GAS)、血浆胃动素(MOT)水平的影响。方法：反流性食管炎患者80例随机分为观察组与对照组各40例。对照组予雷贝拉唑胶囊20 mg,po,qd(早上空腹服用)；观察组在对照组基础上加用气滞胃痛颗粒5 g,po,tid,两组均连续服用4周。观察两组的临床症状与内镜下疗效,比较治疗前后两组患者GAS、MOT水平的变化。结果：两组临床症状与内镜下疗效比较,观察组总有效率分别为95.0%和92.5%,均高于对照组(P<0.05)。两组治疗后GAS、MOT水平均治疗前显著提升(P<0.05),且观察组水平明显高于对照组(P<0.05)。结论：雷贝拉唑联合气滞胃痛颗粒治疗反流性食管炎具有较好的临床疗效,且显著提高GAS、MOT水平,值得临床上广泛应用。
目的：：觀察雷貝拉唑聯閤氣滯胃痛顆粒治療反流性食管炎的臨床療效及對患者血清胃泌素(GAS)、血漿胃動素(MOT)水平的影響。方法：反流性食管炎患者80例隨機分為觀察組與對照組各40例。對照組予雷貝拉唑膠囊20 mg,po,qd(早上空腹服用)；觀察組在對照組基礎上加用氣滯胃痛顆粒5 g,po,tid,兩組均連續服用4週。觀察兩組的臨床癥狀與內鏡下療效,比較治療前後兩組患者GAS、MOT水平的變化。結果：兩組臨床癥狀與內鏡下療效比較,觀察組總有效率分彆為95.0%和92.5%,均高于對照組(P<0.05)。兩組治療後GAS、MOT水平均治療前顯著提升(P<0.05),且觀察組水平明顯高于對照組(P<0.05)。結論：雷貝拉唑聯閤氣滯胃痛顆粒治療反流性食管炎具有較好的臨床療效,且顯著提高GAS、MOT水平,值得臨床上廣汎應用。
목적：：관찰뢰패랍서연합기체위통과립치료반류성식관염적림상료효급대환자혈청위비소(GAS)、혈장위동소(MOT)수평적영향。방법：반류성식관염환자80례수궤분위관찰조여대조조각40례。대조조여뢰패랍서효낭20 mg,po,qd(조상공복복용)；관찰조재대조조기출상가용기체위통과립5 g,po,tid,량조균련속복용4주。관찰량조적림상증상여내경하료효,비교치료전후량조환자GAS、MOT수평적변화。결과：량조림상증상여내경하료효비교,관찰조총유효솔분별위95.0%화92.5%,균고우대조조(P<0.05)。량조치료후GAS、MOT수평균치료전현저제승(P<0.05),차관찰조수평명현고우대조조(P<0.05)。결론：뢰패랍서연합기체위통과립치료반류성식관염구유교호적림상료효,차현저제고GAS、MOT수평,치득림상상엄범응용。
Objective:To explore the clinical effect of Qizhi Weitong granules combined with rabeprazole in the treatment of reflux esophagitis and the influence on the levels of gastrin and motilin. Methods:Totally 80 cases of patients with reflux esophagitis were se-lected, and then randomly divided into the observation group and the control group with 40 cases in each. The control group was treated with rabeprazole, and the observation group was treated with Qizhi Weitong granules additionally. After 4-week treatment, the clinical effect and the influence on the levels of gastrin and motilin in the two groups were compared. Results:By comparing the clinical effect and endoscopic curative in the two groups, the total effective rate of the observation group was 95. 0% and 92. 5%, which was obvious-ly higher than that of the control group. Compared with those before the treatment, the levels of gastrin and motilin in the two groups were significantly improved after the treatment, and the improvement of the observation group was obviously higher than that of the con-trol group with statistically significant difference (P<0. 05). Conclusion: Qizhi Weitong granules combined with rabeprazole in the treatment of reflux esophagitis is effective, which can greatly improve the levels of gastrin and motilin and is worthy of further clinical application.
