中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
5期
809-811
,共3页
小牛脾提取物注射液%FOLFOX4方案%结直肠癌%免疫功能
小牛脾提取物註射液%FOLFOX4方案%結直腸癌%免疫功能
소우비제취물주사액%FOLFOX4방안%결직장암%면역공능
Calf spleen extractive injection%FOLFOX 4 regimen%Colorectal carcinom%Immune function
目的：：观察小牛脾提取物注射液辅助化疗对结直肠癌术后患者的免疫功能的影响。方法：128例结直肠癌术后患者随机分为两组各64例。对照组给予FOLFOX 4方案化疗；观察组在对照组基础上,加用小牛脾提取物注射液10 ml,ivd,d1~d10。14 d为1周期,4周期后比较两组患者免疫功能、外周血WBC、Hb、Plt,以及两组药品不良反应。结果：治疗后,两组CD3+、CD4+、CD8+、CD4+/CD8+等均较治疗前明显升高,且均明显高于对照组治疗后(P<0.05)。与本组治疗前比较,两组治疗后外周血WBC、Plt和Hb水平变化不明显(P>0.05),但治疗后观察组的WBC、Plt明显高于对照组(P<0.05)。观察组药品不良反应发生率明显低于对照组(P<0.05)。结论：结直肠癌术后采用小牛脾提取物注射液辅助化疗,不仅能提高机体免疫功能,还可减轻化疗的骨髓抑制、胃肠毒性。
目的：：觀察小牛脾提取物註射液輔助化療對結直腸癌術後患者的免疫功能的影響。方法：128例結直腸癌術後患者隨機分為兩組各64例。對照組給予FOLFOX 4方案化療；觀察組在對照組基礎上,加用小牛脾提取物註射液10 ml,ivd,d1~d10。14 d為1週期,4週期後比較兩組患者免疫功能、外週血WBC、Hb、Plt,以及兩組藥品不良反應。結果：治療後,兩組CD3+、CD4+、CD8+、CD4+/CD8+等均較治療前明顯升高,且均明顯高于對照組治療後(P<0.05)。與本組治療前比較,兩組治療後外週血WBC、Plt和Hb水平變化不明顯(P>0.05),但治療後觀察組的WBC、Plt明顯高于對照組(P<0.05)。觀察組藥品不良反應髮生率明顯低于對照組(P<0.05)。結論：結直腸癌術後採用小牛脾提取物註射液輔助化療,不僅能提高機體免疫功能,還可減輕化療的骨髓抑製、胃腸毒性。
목적：：관찰소우비제취물주사액보조화료대결직장암술후환자적면역공능적영향。방법：128례결직장암술후환자수궤분위량조각64례。대조조급여FOLFOX 4방안화료；관찰조재대조조기출상,가용소우비제취물주사액10 ml,ivd,d1~d10。14 d위1주기,4주기후비교량조환자면역공능、외주혈WBC、Hb、Plt,이급량조약품불량반응。결과：치료후,량조CD3+、CD4+、CD8+、CD4+/CD8+등균교치료전명현승고,차균명현고우대조조치료후(P<0.05)。여본조치료전비교,량조치료후외주혈WBC、Plt화Hb수평변화불명현(P>0.05),단치료후관찰조적WBC、Plt명현고우대조조(P<0.05)。관찰조약품불량반응발생솔명현저우대조조(P<0.05)。결론：결직장암술후채용소우비제취물주사액보조화료,불부능제고궤체면역공능,환가감경화료적골수억제、위장독성。
Objective:To explore the infuence of calf spleen extractive injection combined with chemotherapy on immune function of the patients after colorectal carcinoma. Methods:Totally 128 cases of postoperative colorectal carcinoma patients were randomly di-vided into two groups with 64 ones in each. The control group only received FOLFOX 4 regimen, while the study group received calf spleen extractive injection additionally from the first day to the tenth day, 10ml, ivd, and 14-day was one cycle. After 4 weeks, im-mune function, peripheral blood leukocytes ( WBC) , hemoglobin ( Hb) and platelet ( Plt) in the two groups were compared, and the adverse reactions were evaluated as well. Results: After the treatment, CD3 +, CD4 +, CD8 + and CD4/CD8 were increased in the study groups, and those in the study group were much higher than those in the control group (P<0. 05). After the treatment, there were no significant changes in WBC, Plt and Hb in the two groups (P>0. 05), while WBC and Plt in the study group were higher than those in the control group (P<0. 05). The incidence of adverse reactions in the study group was lower than that in the control group (P<0. 05). Conclusion:Calf spleen extractive injection combined with chemotherapy not only can increase the immune func-tion, but also alleviate myelosuppression and gastrointestinal toxicity in the treatment of postoperative colorectal carcinoma patients.
