CAJ | 학술논문

顺铂在临床上应用于多种肿瘤的治疗，也会引起广泛的不良反应如肾毒性、肝毒性、耳毒性等，限制了其临床应用，因此临床上主张联合用药以达到增效减毒的作用。本文概述了近些年来关于化学药及中药(中药成分、单味中药及中药复方)对顺铂的增效解毒作用方面的研究进展，为化疗药联合用药研究和临床给药方案的制定提供参考依据。
순박재림상상응용우다충종류적치료，야회인기엄범적불량반응여신독성、간독성、이독성등，한제료기림상응용，인차림상상주장연합용약이체도증효감독적작용。본문개술료근사년래관우화학약급중약(중약성분、단미중약급중약복방)대순박적증효해독작용방면적연구진전，위화료약연합용약연구화림상급약방안적제정제공삼고의거。
Cisplatin is effective in the treatment of various solid tumors. However, its clinical application is limited because of the severe side-effects such as nephrotoxicity, hepatotoxicity, ototoxicity and so on. Drug combination is advocated in clinics for synergism and detoxication. In order to provide some referencs for the research of drug combination and clinical treatment regimen, the research advances in the synergism and detoxication of drug combination of cisplatin with chemicals/ traditional Chinese medicines in recent years are reviewed in the paper.