中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
5期
717-721
,共5页
杨阳%于文惠%杨静%赵长琦
楊暘%于文惠%楊靜%趙長琦
양양%우문혜%양정%조장기
新生发丸%制备工艺%质量标准%正交试验
新生髮汍%製備工藝%質量標準%正交試驗
신생발환%제비공예%질량표준%정교시험
New Shengfa pills%Preparation technique%Quality standard%Orthogonal experiment
目的：：考察新生发丸的制剂工艺及制定质量控制方法。方法：应用正交试验法，选择二苯乙烯苷的含量和干浸膏得率两项指标，优选新生发丸中水提部分药材的最佳提取工艺；二苯乙烯苷的含量通过HPLC测定；采用薄层色谱法对制剂中的当归和牛膝进行了鉴别。结果：最佳提取工艺为，熟地黄等五味药材用12倍水量提取3次，每次1h。薄层鉴别的色谱斑点分离好，阴性无干扰。结论：该制剂工艺合理、可行、质量可控。
目的：：攷察新生髮汍的製劑工藝及製定質量控製方法。方法：應用正交試驗法，選擇二苯乙烯苷的含量和榦浸膏得率兩項指標，優選新生髮汍中水提部分藥材的最佳提取工藝；二苯乙烯苷的含量通過HPLC測定；採用薄層色譜法對製劑中的噹歸和牛膝進行瞭鑒彆。結果：最佳提取工藝為，熟地黃等五味藥材用12倍水量提取3次，每次1h。薄層鑒彆的色譜斑點分離好，陰性無榦擾。結論：該製劑工藝閤理、可行、質量可控。
목적：：고찰신생발환적제제공예급제정질량공제방법。방법：응용정교시험법，선택이분을희감적함량화간침고득솔량항지표，우선신생발환중수제부분약재적최가제취공예；이분을희감적함량통과HPLC측정；채용박층색보법대제제중적당귀화우슬진행료감별。결과：최가제취공예위，숙지황등오미약재용12배수량제취3차，매차1h。박층감별적색보반점분리호，음성무간우。결론：해제제공예합리、가행、질량가공。
Objective:To study the preparation technique and quality standard for new Shengfa pills. Methods: The best water extraction process of the medicinal herbs was optimized by orthogonal test using stilbene glucoside content and dry extract percent as the indices. The content of stilbene glucoside was determined by HPLC, and Hyssop and Chinese angelica in the preparation were identified by TLC. Results:The optimized preparation conditions were as follows:12-fold water was used in the 3-time extraction with 1 h for each time. The spots in TLC were clear without interference from the negative control. Conclusion:The preparation process is reasona-ble and feasible in techniques with controllable quality.
