CAJ | 학술논문

目的：：通过对慢性病贫血(ACD)血清中Hepcidin、IL-1、IL-6、IL-10及TNF-α表达水平变化分析，初步探索多虑平改善贫血的可能作用机制。方法：将60例ACD随机分为4组。对照组(C)：仅治疗ACD的基础病。单纯多虑平治疗组(SD)：多虑平75 mg/d，口服。单纯EPO治疗组(SE)：EPO 150 U/kg，皮下注射，每周三次。多虑平联合EPO治疗组(DE)：EPO150 U/kg，皮下注射，每周三次；加多虑平75 mg/d，口服。用自动化血液分析仪检测血常规，Elisa法检测上述因子的血清含量。结果：与C组相比，SD组、SE组、DE组血清中的检测因子水平均显著下降(P<0.05)；与SE组相比，SD组血清中的检测因子水平改变不明显(P>0.05)；而DE组却明显下降且Hb明显上升(P<0.05)。与SD组相比，DE的血清检测因子水平明显下降且Hb明显上升(P<0.05)。结论：多虑平可降低ACD患者血清中检测因子的水平；多虑平与EPO二者联合治疗ACD的效果，明显优于两药物的单独使用。
목적：：통과대만성병빈혈(ACD)혈청중Hepcidin、IL-1、IL-6、IL-10급TNF-α표체수평변화분석，초보탐색다필평개선빈혈적가능작용궤제。방법：장60례ACD수궤분위4조。대조조(C)：부치료ACD적기출병。단순다필평치료조(SD)：다필평75 mg/d，구복。단순EPO치료조(SE)：EPO 150 U/kg，피하주사，매주삼차。다필평연합EPO치료조(DE)：EPO150 U/kg，피하주사，매주삼차；가다필평75 mg/d，구복。용자동화혈액분석의검측혈상규，Elisa법검측상술인자적혈청함량。결과：여C조상비，SD조、SE조、DE조혈청중적검측인자수평균현저하강(P<0.05)；여SE조상비，SD조혈청중적검측인자수평개변불명현(P>0.05)；이DE조각명현하강차Hb명현상승(P<0.05)。여SD조상비，DE적혈청검측인자수평명현하강차Hb명현상승(P<0.05)。결론：다필평가강저ACD환자혈청중검측인자적수평；다필평여EPO이자연합치료ACD적효과，명현우우량약물적단독사용。
Objective: To detect the changes of serum hepcidin, IL-1, IL-6, IL-10 and TNF-α in treatment of anemia of chronic disease (ACD) by doxepin to preliminarily explore its the mechanism. Methods: Sixty patients were divided into control group doxepin treatment group,EPO treatment group and doxepin combined EPO treatment group. The blood routine of the fresh samples were measured by automated blood analyzers and the levels of hepcidin, IL-1, IL-6, IL-10 and TNF-α in serum were detected by ELISA. Results: Compared with control group, the serum levels of above factors in treatment groups were significantly reduced (P < 0.05). Compared to EPO treatment group, serum levels of above factors in doxepin treatment group were not significantly reduced (P > 0.05), but significantly reduced in doxepin combined EPO treatment group (P < 0.05). The hemoglobin level was also significantly increased in combined group. Compared with doxepin treatment group, in doxepin combined EPO treatment group the serum levels of above factors in Doxepin combined EPO treatment group were significantly reduced while the hemoglobin level was significantly increased (P< 0.05). Conclusion:Doxepin may reduce the serum levels of hepcidin. in ACD patients. Doxepin combined EPO seems much better than single use of EPO or doxepin in treating patients with ACD.