CAJ | 학술논문

目的：分析2011~2013年宜宾地区下呼吸道感染铜绿假单胞菌率的变迁及耐药趋势，指导该地区医务人员合理应用抗菌药物治疗铜绿假单胞菌所致的下呼吸道感染。方法：分析获自宜宾市第一、二人民医院2011年至2013年下呼吸道标本分离出的726株铜绿假单胞菌，比较铜绿假单胞菌感染率的变化趋势，及铜绿假单胞菌12种抗菌药耐药趋势。结果：2011~2013年下呼吸道感染标本中分离出铜绿假单胞菌分别为5.33%、4.86%、2.43%(P<0.05)；药敏结果显示铜绿假单胞菌对β-内酰胺类、喹诺酮类和磺胺类耐药率较高(>21%)，对亚胺培南、哌拉西林他唑巴坦、氨基糖苷类耐药率较低(<20%)。结论：铜绿假单胞菌所致的下呼吸道感染较少；宜宾地区可经验性选择抗菌药物亚胺培南、哌拉西林他唑巴坦、氨基糖苷类治疗可疑铜绿假单胞菌感染。
목적：분석2011~2013년의빈지구하호흡도감염동록가단포균솔적변천급내약추세，지도해지구의무인원합리응용항균약물치료동록가단포균소치적하호흡도감염。방법：분석획자의빈시제일、이인민의원2011년지2013년하호흡도표본분리출적726주동록가단포균，비교동록가단포균감염솔적변화추세，급동록가단포균12충항균약내약추세。결과：2011~2013년하호흡도감염표본중분리출동록가단포균분별위5.33%、4.86%、2.43%(P<0.05)；약민결과현시동록가단포균대β-내선알류、규낙동류화광알류내약솔교고(>21%)，대아알배남、고랍서림타서파탄、안기당감류내약솔교저(<20%)。결론：동록가단포균소치적하호흡도감염교소；의빈지구가경험성선택항균약물아알배남、고랍서림타서파탄、안기당감류치료가의동록가단포균감염。
Objective: To Analyze the change of infections rate and drug resistance of Pseudomonas aeruginosa in lower respiratory tract infections in Yibin region from 2011 to 2013 in order to guide the rational use of antimicrobial drugs. Methods: 726 strains of Pseudomonas aeruginosa isolated from lower respiratory tract specimens from the first and second People's Hospitals of Yibin city from 2011 to 2013 were abalyzed, then the infections rate and 12 kinds of antimicrobial drug resistance trends in the 3 years were compared. Results: The isolation rate of Pseudomonas aeruginosa in 2011, and 2013 were 5.33%, 4.86% and 2.43% respectively (P <0.05), susceptibility of Pseudomonas aeruginosa to β- lactams, quinolones and sulfa drugs were higher (> 21%). While to Imipenem, piperacillin-tazobactam and aminoglycosides were lower (< 20%). Conclusion: The lower respiratory tract infection caused by Pseudomonas aeruginosa is less common in Yibin region, The treatment of suspected Pseudomonas aeruginosa infection in this region can empirically select the antibiotics of imipenem, Piperacillin-tazobactam and aminoglycoside.