CAJ | 학술논문

目的：：探讨骨髓增生异常综合征(Myelodysplastic syndrome，MDS)的骨髓细胞遗传学改变及其与预后关系。方法：选择2001年WHO发布的新的MDS分型标准诊断的患者62例，根据国际预后评分系统(international prognosis scoring system，IPSS)积分将患者分为不同的危险组，对其骨髓细胞采用短期培养法制备染色体标本G显带后进行核型分析。结果：62例MDS患者中染色体核型正常24例，核型异常38例，畸变率为61.3%，包括数目异常22例，结构异常9例。根据IPSS计算后将患者染色体核型不同分为不同的危险组，其存活期应用Log-rank检验，不同危险组其总生存(OS)率差异有统计学意义(P≤0.05)。结论：染色体核型分析对MDS诊断及预后评估有重要意义。
목적：：탐토골수증생이상종합정(Myelodysplastic syndrome，MDS)적골수세포유전학개변급기여예후관계。방법：선택2001년WHO발포적신적MDS분형표준진단적환자62례，근거국제예후평분계통(international prognosis scoring system，IPSS)적분장환자분위불동적위험조，대기골수세포채용단기배양법제비염색체표본G현대후진행핵형분석。결과：62례MDS환자중염색체핵형정상24례，핵형이상38례，기변솔위61.3%，포괄수목이상22례，결구이상9례。근거IPSS계산후장환자염색체핵형불동분위불동적위험조，기존활기응용Log-rank검험，불동위험조기총생존(OS)솔차이유통계학의의(P≤0.05)。결론：염색체핵형분석대MDS진단급예후평고유중요의의。
Objective: To analyse cytogenetic changes in patients with myelodysplastic syndrome (MDS)and to investigate their correlation with prognosis. Methods: 62 patients with MDS were selected by the new diagnostic criteria of MDS issued by WHO in 2001. These patients were divided into high,medium and low risk groups according to scores assessed by International Prognosis Scoring System (IPSS) Karyotypes of bone marrow cells were analyzed after chromosome samples had showed Giemsa banding. Results: In 62 patients with MDS. the cases of normal karyotype and abnormal karyotype were 24 and 38 respectively. The aberration rate was 61.3%,including abnormal number 22 cases and anomalous structure 9 cases. Total survival rate in different risk groups had significant difference in Log-rank test (P < 0.05). Conclusion: Karyotype analysis is an important indicator for diagnosis and prognosis of MDS.