CAJ | 학술논문

MicroRNA(miRNA)是一类小型非编码RNA，由大约22个核苷酸组成，在转录后水平发挥调控基因表达的功能。越来越多的研究发现，MiRNA在肝癌细胞增殖、分化、凋亡中起着重要作用，其特异性的表达，在肝癌的发生发展过程中扮演着重要的角色。目前学界公认的MicroRNA引起肿瘤发生的机制概括起来如下：(1)RNA聚合酶负责的转录失调有可能是g肝癌肿瘤发生原因；(2) MicroRNA调控网络中相关SNPs改变导致成熟的MicroRNA合成障碍与表达失调；(3)MicroRNA合成通路的关键蛋白界常引起MicroRNA表达改变。因此本文拟对MiRNA单核苷酸多态性在肝细胞癌中的作用作一综述。
MicroRNA(miRNA)시일류소형비편마RNA，유대약22개핵감산조성，재전록후수평발휘조공기인표체적공능。월래월다적연구발현，MiRNA재간암세포증식、분화、조망중기착중요작용，기특이성적표체，재간암적발생발전과정중분연착중요적각색。목전학계공인적MicroRNA인기종류발생적궤제개괄기래여하：(1)RNA취합매부책적전록실조유가능시g간암종류발생원인；(2) MicroRNA조공망락중상관SNPs개변도치성숙적MicroRNA합성장애여표체실조；(3)MicroRNA합성통로적관건단백계상인기MicroRNA표체개변。인차본문의대MiRNA단핵감산다태성재간세포암중적작용작일종술。
Micrornas (miRNA) is a kind of small non-coding RNA, is composed of about 22 nucleotides, after the transcription level the function of regulating gene expression. A growing number of studies have found that micrornas in hepatocellular carcinoma cell proliferation, differentiation, apoptosis plays an important role in the expression of its specificity, in the occurrence of cancer of the liver plays an important role in the process of development. Are recognized as micrornas cause tumorigenesis mechanisms include: (1) the transcription of RNA polymerase is responsible for the disorder have g liver cancer could be the cause; (2) mirna regulation network in the mature mirnas related SNPs changed synthetic barrier and expression disorders; (3) mirna synthesis pathway of key protein bound often cause mirna expression change. So the paper of micrornas single nucleotide polymorphisms in the role of hepatocellular carcinoma (HCC).