新疆医科大学学报
新疆醫科大學學報
신강의과대학학보
JOURNAL OF XINJIANG MEDICAL UNIVERSITY
2015年
5期
533-535
,共3页
夏韩%热娜·阿布力孜%安恒庆%哈木拉提·吐送%王文光%拜合提亚·阿扎提%木拉提·热夏提%张立东%王玉杰
夏韓%熱娜·阿佈力孜%安恆慶%哈木拉提·吐送%王文光%拜閤提亞·阿扎提%木拉提·熱夏提%張立東%王玉傑
하한%열나·아포력자%안항경%합목랍제·토송%왕문광%배합제아·아찰제%목랍제·열하제%장립동%왕옥걸
肾癌%氨基酸%生物学
腎癌%氨基痠%生物學
신암%안기산%생물학
renal carcinoma%amino acid%biology
目的：探讨肾癌患者术前血清与健康人血清的氨基酸差异及其临床意义。方法收集病理确诊的肾癌患者140例（病例组）术前血清及140例健康人（对照组）的血清标本，应用高效液相色谱（HPLC）代谢组学法检测两组标本中血清游离氨基酸的含量，并进行比较分析。结果与对照组相比，病例组肾癌患者血清存在明显的氨基酸代谢异常，其中天冬氨酸、丝氨酸、甘氨酸、组氨酸、精氨酸、苏氨酸、丙氨酸、脯氨酸、胱氨酸、酪氨酸、缬氨酸、蛋氨酸、异亮氨酸、亮氨酸、苯丙氨酸和赖氨酸含量呈明显下降趋势，两组差异具有统计学意义（P ＜0．05）。结论肾癌患者血清氨基酸含量较正常健康人整体下降，此结果对进一步研究其发生机理以及临床特异性标记物的研究有重要意义。
目的：探討腎癌患者術前血清與健康人血清的氨基痠差異及其臨床意義。方法收集病理確診的腎癌患者140例（病例組）術前血清及140例健康人（對照組）的血清標本，應用高效液相色譜（HPLC）代謝組學法檢測兩組標本中血清遊離氨基痠的含量，併進行比較分析。結果與對照組相比，病例組腎癌患者血清存在明顯的氨基痠代謝異常，其中天鼕氨痠、絲氨痠、甘氨痠、組氨痠、精氨痠、囌氨痠、丙氨痠、脯氨痠、胱氨痠、酪氨痠、纈氨痠、蛋氨痠、異亮氨痠、亮氨痠、苯丙氨痠和賴氨痠含量呈明顯下降趨勢，兩組差異具有統計學意義（P ＜0．05）。結論腎癌患者血清氨基痠含量較正常健康人整體下降，此結果對進一步研究其髮生機理以及臨床特異性標記物的研究有重要意義。
목적：탐토신암환자술전혈청여건강인혈청적안기산차이급기림상의의。방법수집병리학진적신암환자140례（병례조）술전혈청급140례건강인（대조조）적혈청표본，응용고효액상색보（HPLC）대사조학법검측량조표본중혈청유리안기산적함량，병진행비교분석。결과여대조조상비，병례조신암환자혈청존재명현적안기산대사이상，기중천동안산、사안산、감안산、조안산、정안산、소안산、병안산、포안산、광안산、락안산、힐안산、단안산、이량안산、량안산、분병안산화뢰안산함량정명현하강추세，량조차이구유통계학의의（P ＜0．05）。결론신암환자혈청안기산함량교정상건강인정체하강，차결과대진일보연구기발생궤리이급림상특이성표기물적연구유중요의의。
Objective To investigate the differences in serum amino acids in the healthy people and patients with renal cell carcinoma (RCC)and to explore the clinical significance.Methods 140 samples of serum a-mino acids in RCC patients and 140 samples of serum amino acids in healthy people were collected and ana-lyzed by the HPLC to detect and compare their content of free amino acids in serum.Results Compared with the healthy people in the control group,patients with renal cell carcinoma (RCC)had obvious dis-turbance of amino acid metabolism in their serum,with obvious decline in the plasma aspartate,the ser-ine,the glycine,the histidine,the arginine,the threonine,the alanine,the proline,the tyrosine,the cys-tine,the valine,the methionine,the lysine,the isoleucine,the leucine,and the phenylalanine,and the statistical difference was significant (P <0.05).Conclusion The detection of specific amino acids in pa-tients with kidney cancer was proved significant for the study on cancer development mechanism and its clinical specific biomarkers.
