CAJ | 학술논문

目的：初步探讨前列腺癌骨转移的危险因素。方法以 SPECT 全身骨显像为诊断前列腺癌骨转移的金标准，采用单中心对照研究的方法分析235例前列腺癌患者的年龄、Gleson 评分、血清前列腺特异性抗原（TP-SA）、血清游离前列腺特异性抗原（FPSA）及血清 F／T 值与前列腺癌骨转移的相关性。结果235例前列腺癌患者中101例发生骨转移，134例未发生骨转移，单因素分析显示年龄、Gleason 评分、TPSA、FPSA、F／T 值与前列腺癌骨转移密切相关（P ＜0．05），多因素 Logistic 回归分析显示：年龄（OR ＝1．08，P ＜0．05）、Gleason 评分（OR ＝2．90，P ＜0．05）、TPSA 值（OR ＝1．05，P ＜0．05）是其主要的独立危险因素。分层研究显示；在年龄≥70岁、Gleason 评分≥7分、TPSA＞20ng／ml 组中骨转移的患者明显多于其他组，差异均具有统计学意义（P ＜0．05）。结论年龄、Gleason 评分及 TPSA 是前列腺癌骨转移的主要危险因素，年龄≥70岁、Gleason 评分≥7分、TPSA＞20 ng／mL 时将增加患者骨转移的风险。
목적：초보탐토전렬선암골전이적위험인소。방법이 SPECT 전신골현상위진단전렬선암골전이적금표준，채용단중심대조연구적방법분석235례전렬선암환자적년령、Gleson 평분、혈청전렬선특이성항원（TP-SA）、혈청유리전렬선특이성항원（FPSA）급혈청 F／T 치여전렬선암골전이적상관성。결과235례전렬선암환자중101례발생골전이，134례미발생골전이，단인소분석현시년령、Gleason 평분、TPSA、FPSA、F／T 치여전렬선암골전이밀절상관（P ＜0．05），다인소 Logistic 회귀분석현시：년령（OR ＝1．08，P ＜0．05）、Gleason 평분（OR ＝2．90，P ＜0．05）、TPSA 치（OR ＝1．05，P ＜0．05）시기주요적독립위험인소。분층연구현시；재년령≥70세、Gleason 평분≥7분、TPSA＞20ng／ml 조중골전이적환자명현다우기타조，차이균구유통계학의의（P ＜0．05）。결론년령、Gleason 평분급 TPSA 시전렬선암골전이적주요위험인소，년령≥70세、Gleason 평분≥7분、TPSA＞20 ng／mL 시장증가환자골전이적풍험。
Objective To explore the risk factors of bone metastasis of prostate cancer.Methods On SPECT bone scan is the gold standard for the diagnosis of prostate carcinoma with bone metastasis.By u-sing the method of comparative study of single center we analyzed 235 prostate cancer patients Age, Gleson score,Serum prostate specific antigen,Serumfree prostate specific antigen and Serum F/T level which is correlation with bone metastasis of prostate cancer.Results 235 cases of prostate cancer patients with bone metastasis occurred in 101 cases and 134 cases did not have bone metastasis.By univariate analy-sis,bone metastasis of prostate cancer was correlated with age,Gleason score,TPSA,FPSA,F/T (P <0.05).Multivariate Logistic regression analysis showed that age (OR =1.08),Gleason score (OR =2.90), TPSA (OR = 1.05)are the independent risk factors and Stratification study shows ≥ 70 years,Gleason score ≥7 score,TPSA>20 ng/mL group of bone metastasis in patients with significantly more than the other groups,there were significant differences (P <0.05).Conclusion Age,Gleason score and TPSA are risk factors of patients with bone metastasis of prostate cancer in our center and ≥70 years,Gleason score ≥7 score,TPSA>20 ng/mL will increase the risk of patients with bone metastasis.