CAJ | 학술논문

目的：：动态描述药物浓度在体内的不同时间的变化，了解体内药物的行为模式和规律，为个体化治疗和避免药物不良反应提供参考，为开展生理药物动力学模型动态描述奠定基础。方法：使用Simulink动态仿真处理二室模型，建立二室动态模型进行曲线拟合和参数估计，将结果与3P97软件拟合结果进行比较。结果：比较仿真结果与3P97软件拟合结果，两者无显著差异。结论：动态模型可以用于口服给药的二室模型的动态仿真。动态仿真结果更加直观，并纠正了3P97软件的拟合偏差。
목적：：동태묘술약물농도재체내적불동시간적변화，료해체내약물적행위모식화규률，위개체화치료화피면약물불량반응제공삼고，위개전생리약물동역학모형동태묘술전정기출。방법：사용Simulink동태방진처리이실모형，건립이실동태모형진행곡선의합화삼수고계，장결과여3P97연건의합결과진행비교。결과：비교방진결과여3P97연건의합결과，량자무현저차이。결론：동태모형가이용우구복급약적이실모형적동태방진。동태방진결과경가직관，병규정료3P97연건적의합편차。
Objective:To dynamically describe the drug concentration change in different time in vivo to understand the in vivo be-havior patterns and rules of drugs, provide reference for performing individual treatment and avoiding adverse drug reactions and lay foundation for dynamic description of physiological pharmacokinetic model. Methods:A two-compartment model was established using Simulink dynamic simulation and used in curve fitting and parameter estimation. The results from the model were compared with those from 3P97 software. Results:There was no significant difference between the results from the dynamic model and those from 3P97 soft-ware. Conclusion:The dynamic model can be used to dynamically simulate two-compartment model for oral administration. The re-sults from the dynamic simulation are more direct, and can correct the fitting error in 3P97 software.