CAJ | 학술논문

目的：观察和探讨不同剂量的辛伐他汀治疗社区高脂血症的临床应用效果。方法120例高脂血症患者，随机分为小剂量组和大剂量组，每组60例。小剂量组采用辛伐他汀20 mg/d治疗，大剂量组采用辛伐他汀40 mg/d治疗，连续治疗8周，观察两组患者的临床疗效，治疗前后的总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)的水平以及不良反应。结果大剂量组的临床总有效率为90.0%，小剂量组的临床总有效率为76.7%，两组比较，差异有统计学意义(P<0.05)；治疗后大剂量组的TC、LDL-C、HDL-C、TG的水平显著优于小剂量组，差异有统计学意义(P<0.05)；两组患者均无严重的不良反应。结论大剂量辛伐他汀治疗高脂血症的临床有效率高，改善TC、LDL-C、HDL-C、TG的水平的明显，不良反应少，值得临床推广应用。
목적：관찰화탐토불동제량적신벌타정치료사구고지혈증적림상응용효과。방법120례고지혈증환자，수궤분위소제량조화대제량조，매조60례。소제량조채용신벌타정20 mg/d치료，대제량조채용신벌타정40 mg/d치료，련속치료8주，관찰량조환자적림상료효，치료전후적총담고순(TC)、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)、감유삼지(TG)적수평이급불량반응。결과대제량조적림상총유효솔위90.0%，소제량조적림상총유효솔위76.7%，량조비교，차이유통계학의의(P<0.05)；치료후대제량조적TC、LDL-C、HDL-C、TG적수평현저우우소제량조，차이유통계학의의(P<0.05)；량조환자균무엄중적불량반응。결론대제량신벌타정치료고지혈증적림상유효솔고，개선TC、LDL-C、HDL-C、TG적수평적명현，불량반응소，치득림상추엄응용。
Objective To observe and investigate clinical application effects of different simvastatin doses in the treatment of community hyperlipidaemia. Methods A total of 120 hyperlipidaemia patients were randomly divided into small dose group and large dose group, with 60 cases in each group. The small dose group received simvastatin as 20 mg/d, and the large dose group received simvastatin as 40 mg/d. Treatment lasted for 8 weeks, and observations were made on clinical effects, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) levels before and after treatment, and adverse reactions in the two groups. Results The large dose group had clinical total effective rate as 90.0%, and that in the small dose group was 76.7%. The difference between the two groups had statistical significance (P<0.05). After treatment, the large dose group had much lower levels of TC, LDL-C, HDL-C, and TG than the small dose group, and their differences had statistical significance (P<0.05). Both groups had no severe adverse reactions. Conclusion Large dose of simvastatin can provide high effective rate in treating hyperlipidaemia, and it can effectively improve TC, LDL-C, HDL-C, and TG levels with few adverse reactions. It is worthy of clinical promotion and application.