实用医院临床杂志
實用醫院臨床雜誌
실용의원림상잡지
PRACTICAL JOURNAL OF CLINICAL MEDICINE
2015年
3期
35-37,38
,共4页
刘玉萍%马孝湘%王林%程幼夫%帅平%何霞%杨雁华%甘霞
劉玉萍%馬孝湘%王林%程幼伕%帥平%何霞%楊雁華%甘霞
류옥평%마효상%왕림%정유부%수평%하하%양안화%감하
乙醛脱氢酶2%基因多态性%原发性高血压%动脉硬化
乙醛脫氫酶2%基因多態性%原髮性高血壓%動脈硬化
을철탈경매2%기인다태성%원발성고혈압%동맥경화
Aldehyde dehydrogenase 2%Gene polymorphism%Essential hypertension%Arteriosclerosis
目的：探讨乙醛脱氢酶2（ALDH2）基因多态性与原发性高血压（essentia1 hypertension，EH）患者动脉硬化的关系。方法按臂踝脉搏传导速度（brachial ankle pulse wave velocity ，baPWV）将四川省内的300例汉族EH患者分为动脉硬化组（214例）和非动脉硬化组（86例），采用DNA微阵列芯片法检测比较两组ALDH2基因的多态性分布，并进行多因素的Lo－gistic回归分析。结果两组基因型分布均符合Hardy－Weinberg 平衡。与非动脉硬化组相比，动脉硬化组ALDH2基因AA／AG基因型和A等位基因频率明显增加，差异有统计学意义（分别为61．2％vs 38．4％和34．6％vs 20．9％，P＜0．05）。 Logistic回归分析显示，在调整了年龄、性别、体重指数、吸烟、饮酒、收缩压、舒张压、血脂等传统危险因素后，ALDH2基因多态性与EH患者动脉硬化相关（ OR ＝0．399，95％CI：0．327～1．245，P ＝0．038）。结论四川省内汉族人群ALDH2基因多态性与EH患者动脉硬化相关。
目的：探討乙醛脫氫酶2（ALDH2）基因多態性與原髮性高血壓（essentia1 hypertension，EH）患者動脈硬化的關繫。方法按臂踝脈搏傳導速度（brachial ankle pulse wave velocity ，baPWV）將四川省內的300例漢族EH患者分為動脈硬化組（214例）和非動脈硬化組（86例），採用DNA微陣列芯片法檢測比較兩組ALDH2基因的多態性分佈，併進行多因素的Lo－gistic迴歸分析。結果兩組基因型分佈均符閤Hardy－Weinberg 平衡。與非動脈硬化組相比，動脈硬化組ALDH2基因AA／AG基因型和A等位基因頻率明顯增加，差異有統計學意義（分彆為61．2％vs 38．4％和34．6％vs 20．9％，P＜0．05）。 Logistic迴歸分析顯示，在調整瞭年齡、性彆、體重指數、吸煙、飲酒、收縮壓、舒張壓、血脂等傳統危險因素後，ALDH2基因多態性與EH患者動脈硬化相關（ OR ＝0．399，95％CI：0．327～1．245，P ＝0．038）。結論四川省內漢族人群ALDH2基因多態性與EH患者動脈硬化相關。
목적：탐토을철탈경매2（ALDH2）기인다태성여원발성고혈압（essentia1 hypertension，EH）환자동맥경화적관계。방법안비과맥박전도속도（brachial ankle pulse wave velocity ，baPWV）장사천성내적300례한족EH환자분위동맥경화조（214례）화비동맥경화조（86례），채용DNA미진렬심편법검측비교량조ALDH2기인적다태성분포，병진행다인소적Lo－gistic회귀분석。결과량조기인형분포균부합Hardy－Weinberg 평형。여비동맥경화조상비，동맥경화조ALDH2기인AA／AG기인형화A등위기인빈솔명현증가，차이유통계학의의（분별위61．2％vs 38．4％화34．6％vs 20．9％，P＜0．05）。 Logistic회귀분석현시，재조정료년령、성별、체중지수、흡연、음주、수축압、서장압、혈지등전통위험인소후，ALDH2기인다태성여EH환자동맥경화상관（ OR ＝0．399，95％CI：0．327～1．245，P ＝0．038）。결론사천성내한족인군ALDH2기인다태성여EH환자동맥경화상관。
Objective To investigate the relationship between arteriosclerosis in patients with essential hypertension ( EH) and aldehyde dehydrogenase 2(ALDH2)gene polymorphism.Methods Three hundred EH patients of Han population in Sichuan ,China were divided into atherosclerosis group(n =214)and non arteriosclerosis group(n =86)according to brachial ankle pulse wave veloci-ty(baPWV).The ALDH2 gene polymorphism distribution was compared between the two groups by using a DNA micro -array chip,and analyzed by using the multi-factor Logistic regression analysis .Results The genotype distributions of the two groups were in accord-ance with Hardy-Weinberg balance .Compared with the non arteriosclerosis group ,the frequencies of AA/AG genotypes and A allele of ALDH2 gene were apparently increased in the atherosclerosis group (61.2% vs 38.4% and 34.6% vs 20.9%,respectively;all P<0.05 ) .The Logistic regression analysis revealed that ALDH 2 gene polymorphism was correlated with arteriosclerosis in addition to tra-ditional risk factors such as age ,gender,smoking,alcohol consumption,BMI,systolic blood pressure,diastolic blood pressure and blood lipids? as well as other factors ( OR =0.399 ,95%CI:0.327~1.245 ,P =0.038 ) .Conclusion The ALDH2 gene polymorphism is associated with arteriosclerosis in EH patients of Han population in Sichuan ,Provincial.
