CAJ | 학술논문

目的：探讨临床药师药学干预对呼吸内科合理使用抗生素的影响。方法随机抽取临床药师药学干预前后呼吸内科病例资料各300份，比较干预前后抗生素使用情况、抗感染效果、合理使用等差异。结果干预后抗生素使用率明显低于干预前（71．3％VS 95．7％，P＝0．000）；单联抗生素使用率明显高于干预前（28．7％VS 19．0％，P ＝0．028），三联及以上抗生素明显低于干预前（20．0％VS 43．3％，P ＝0．000）；平均住院费用明显少于干预前[（1965．7±265．7） VS （2600．8±316．5）元，P＜0．01]；抗生素使用不合理性明显低于干预前（20．1％VS 34．2％，P＜0．01）。结论临床药师药学干预可促进呼吸内科合理使用抗生素，指导医生用药行为。
목적：탐토림상약사약학간예대호흡내과합리사용항생소적영향。방법수궤추취림상약사약학간예전후호흡내과병례자료각300빈，비교간예전후항생소사용정황、항감염효과、합리사용등차이。결과간예후항생소사용솔명현저우간예전（71．3％VS 95．7％，P＝0．000）；단련항생소사용솔명현고우간예전（28．7％VS 19．0％，P ＝0．028），삼련급이상항생소명현저우간예전（20．0％VS 43．3％，P ＝0．000）；평균주원비용명현소우간예전[（1965．7±265．7） VS （2600．8±316．5）원，P＜0．01]；항생소사용불합이성명현저우간예전（20．1％VS 34．2％，P＜0．01）。결론림상약사약학간예가촉진호흡내과합리사용항생소，지도의생용약행위。
Objective To investigate the effect of clinical pharmacists ’pharmaceutical intervention on reasonable use of antibi-otics in department of respiratory medicine .Methods The clinical data of 300 cases before and after clinical pharmacists ’pharmaceuti-cal intervention were randomly collected .The differences in application of antibiotics ,anti-infection effect and reasonable use before and after intervention were compared.Results After the intervention,antibiotics usage were significantly lower (71.3% vs 95.7%,P =0.000),single union antibiotics usage was significantly higher (28.7%vs 19.0%,P =0.028) and sanlian and above antibiotics were significantly lower(20.0%vs 43.3%,P =0.0001) when compared to before the intervention .The hospitalization cost was also signifi-cantly less than before intervention(1965.7 ±265.7)yuan vs (2600.8 ±316.5 yuan)].The irrational antibiotic use was significantly lower than before intervention(20.1% vs 34.2%).Conclusion Clinical pharmacists’pharmaceutical intervention can promote rea-sonable use of antibiotics ,and regulate behavior of doctor ’s medication .