中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
5期
766-769
,共4页
叶方%李丽%杨光义%黄良永%张晨宁%魏晋宝
葉方%李麗%楊光義%黃良永%張晨寧%魏晉寶
협방%리려%양광의%황량영%장신저%위진보
金茵清热口服液%半仿生提取%醇沉浓度%综合评价
金茵清熱口服液%半倣生提取%醇沉濃度%綜閤評價
금인청열구복액%반방생제취%순침농도%종합평개
Jinyin Qingre oral liquids%Semi-bionic extraction%Alcohol concentration%Comprehensive evaluation
目的::优选金茵清热口服液半仿生提取( SBE)液的醇沉浓度。方法:按比例分割法设立5个醇沉浓度30%、55%、61.25%、67.5%、80%进行平行试验。以绿原酸、栀子苷、丹酚酸B、总酚酸得率和干浸膏收率为指标进行考察,将各指标数据标准化处理,采用设定的加权系数进行综合评价得出综合评价值Y,根据Y值大小优选金茵清热口服液的SBE液醇沉浓度。结果:5个指标综合评价Y值由大到小的顺序为:30%>61.25%>55%>80%>67.5%。结论:结合口服液的澄明度问题与生产实际,以含醇量61.25%为最佳醇沉浓度。
目的::優選金茵清熱口服液半倣生提取( SBE)液的醇沉濃度。方法:按比例分割法設立5箇醇沉濃度30%、55%、61.25%、67.5%、80%進行平行試驗。以綠原痠、梔子苷、丹酚痠B、總酚痠得率和榦浸膏收率為指標進行攷察,將各指標數據標準化處理,採用設定的加權繫數進行綜閤評價得齣綜閤評價值Y,根據Y值大小優選金茵清熱口服液的SBE液醇沉濃度。結果:5箇指標綜閤評價Y值由大到小的順序為:30%>61.25%>55%>80%>67.5%。結論:結閤口服液的澄明度問題與生產實際,以含醇量61.25%為最佳醇沉濃度。
목적::우선금인청열구복액반방생제취( SBE)액적순침농도。방법:안비례분할법설립5개순침농도30%、55%、61.25%、67.5%、80%진행평행시험。이록원산、치자감、단분산B、총분산득솔화간침고수솔위지표진행고찰,장각지표수거표준화처리,채용설정적가권계수진행종합평개득출종합평개치Y,근거Y치대소우선금인청열구복액적SBE액순침농도。결과:5개지표종합평개Y치유대도소적순서위:30%>61.25%>55%>80%>67.5%。결론:결합구복액적징명도문제여생산실제,이함순량61.25%위최가순침농도。
Objective: To optimize the alcohol concentration for Jinyin Qingre oral liquids extracted by semi-bionic extraction (SBE). Methods:Using proportional division method to set up 5 alcohol concentration 30%,55%,61. 25%,67. 5%,80% for the ex-periment . The dried extract yield and the contents of chlorogenic acid ,geniposide,salviandic acid B and total phenolic acid were set up as indexes which were standardized as the comprehensive evaluation value ( Y) ,using the weighting coefficient had been set. Choosing the appropriate concentration by comparing the value of Y. Results:The order of comprehensive evaluation value was as follows:30%>61. 25% >55% >80% >67. 5%. Conclusion:Combining the clarity of the oral liquids, the best alcohol concentration in SBE for Jinyin Qingre oral liquids is 61. 25%.