CAJ | 학술논문

目的：评估潜艇艇员交感－肾上腺髓质轴应激标志物嗜铬粒蛋白A（ CgA）、β-内啡肽（β-EP）、唾液分泌型免疫球蛋白A （ sIgA）等含量的变化在长航军事作业应激中的意义。方法选择海军某部潜艇29名艇员，分别在长航训练数周后归来时及上岸休整9个月后采集唾液标本，酶联免疫吸附法分别检测唾液中CgA、β-EP和sIgA的水平。同时采集军事医学科学院研究生部一年级28名与潜艇艇员年龄相当的男性研究生唾液标本作为非应激人群对照。结果长航作业应激可导致潜艇艇员唾液中CgA、β-EP和sIgA水平显著降低，在休整后上述各项指标获得恢复。结论长航军事作业应激可以显著降低唾液CgA、β-EP和sIgA的水平，提示机体交感－肾上腺髓质系统的功能受到抑制，这些应激标志物含量改变的生物学意义尚待未来进行深入评估。
목적：평고잠정정원교감－신상선수질축응격표지물기락립단백A（ CgA）、β-내배태（β-EP）、타액분비형면역구단백A （ sIgA）등함량적변화재장항군사작업응격중적의의。방법선택해군모부잠정29명정원，분별재장항훈련수주후귀래시급상안휴정9개월후채집타액표본，매련면역흡부법분별검측타액중CgA、β-EP화sIgA적수평。동시채집군사의학과학원연구생부일년급28명여잠정정원년령상당적남성연구생타액표본작위비응격인군대조。결과장항작업응격가도치잠정정원타액중CgA、β-EP화sIgA수평현저강저，재휴정후상술각항지표획득회복。결론장항군사작업응격가이현저강저타액CgA、β-EP화sIgA적수평，제시궤체교감－신상선수질계통적공능수도억제，저사응격표지물함량개변적생물학의의상대미래진행심입평고。
Objective To evaluate the effect of military performance stress on the changes of concentrations in salivary chromogranin A ( CgA) ,β-endorphin (β-EP) and salivary IgA ( sIgA) of submariners.Methods Twenty-nine submarine soldiers were selected, and their saliva samples were collected separately at the end of a long dive trip and nine months after relaxation ashore.In addition,the saliva samples of twenty-eight graduate students were collected as the normal control.The method of ELISA was used to detect the level of salivary CgA,β-EP and sIgA.Results After long-term dive training, the submariners showed significantly decreased CgA,β-EP and sIgA.Conclusion After a long term dive trip, chronic military performance stress is associated with the decline of salivary CgA,β-EP and sIgA, indicating that the function of sympathet-ic adrenal medulla is suppressed.The biological significance of these changes needs to be assessed in the future.