皮肤性病诊疗学杂志
皮膚性病診療學雜誌
피부성병진료학잡지
DIAGNOSIS AND THERAPY JOURNAL OF DERMATO-VENEREOLOGY
2015年
2期
95-98
,共4页
杨斌%白顺%薛耀华%覃晓琳%吕萍%郑和平
楊斌%白順%薛耀華%覃曉琳%呂萍%鄭和平
양빈%백순%설요화%담효림%려평%정화평
梅毒%治疗前%抗体表达差异
梅毒%治療前%抗體錶達差異
매독%치료전%항체표체차이
Syphilis%Before treatment%Differences expression of antibody
目的:分析梅毒各个时期治疗前IgG、IgA和 IgM抗体的表达差异。方法:采用免疫印迹法检测已确诊的34份不同时期(一期8例,二期15例,三期11例)梅毒患者治疗前血清中IgG、IgA和IgM Tp蛋白表达情况。结果:IgG抗体Tp47、Tp45、Tp34和Tp15在治疗前各期梅毒患者血清中均100%表达,Tp33在三期梅毒中的阳性率(63.6%)明显低于一、二期梅毒(均为100%),差异有统计学意义(P=0.009)。 IgA抗体各期表达无明显差异,其中一期梅毒中Tp41、Tp34、Tp33和Tp30抗体以及三期梅毒中Tp33均无阳性条带出现。 IgM抗体Tp41和Tp37在各期梅毒患者血清中阳性率差异有统计学意义( P值分别为0.035、0.020),其余差异均无统计学意义。结论:强阳性的 Tp 蛋白 Tp47、Tp45和Tp15可作为早期梅毒诊断的指标;在各期表达有明显差异的Tp41、Tp37和Tp33可考虑作为临床分期观察指标;Tp45、Tp41、Tp17和Tp15可作为以后临床治疗效果的辅助诊断参考。
目的:分析梅毒各箇時期治療前IgG、IgA和 IgM抗體的錶達差異。方法:採用免疫印跡法檢測已確診的34份不同時期(一期8例,二期15例,三期11例)梅毒患者治療前血清中IgG、IgA和IgM Tp蛋白錶達情況。結果:IgG抗體Tp47、Tp45、Tp34和Tp15在治療前各期梅毒患者血清中均100%錶達,Tp33在三期梅毒中的暘性率(63.6%)明顯低于一、二期梅毒(均為100%),差異有統計學意義(P=0.009)。 IgA抗體各期錶達無明顯差異,其中一期梅毒中Tp41、Tp34、Tp33和Tp30抗體以及三期梅毒中Tp33均無暘性條帶齣現。 IgM抗體Tp41和Tp37在各期梅毒患者血清中暘性率差異有統計學意義( P值分彆為0.035、0.020),其餘差異均無統計學意義。結論:彊暘性的 Tp 蛋白 Tp47、Tp45和Tp15可作為早期梅毒診斷的指標;在各期錶達有明顯差異的Tp41、Tp37和Tp33可攷慮作為臨床分期觀察指標;Tp45、Tp41、Tp17和Tp15可作為以後臨床治療效果的輔助診斷參攷。
목적:분석매독각개시기치료전IgG、IgA화 IgM항체적표체차이。방법:채용면역인적법검측이학진적34빈불동시기(일기8례,이기15례,삼기11례)매독환자치료전혈청중IgG、IgA화IgM Tp단백표체정황。결과:IgG항체Tp47、Tp45、Tp34화Tp15재치료전각기매독환자혈청중균100%표체,Tp33재삼기매독중적양성솔(63.6%)명현저우일、이기매독(균위100%),차이유통계학의의(P=0.009)。 IgA항체각기표체무명현차이,기중일기매독중Tp41、Tp34、Tp33화Tp30항체이급삼기매독중Tp33균무양성조대출현。 IgM항체Tp41화Tp37재각기매독환자혈청중양성솔차이유통계학의의( P치분별위0.035、0.020),기여차이균무통계학의의。결론:강양성적 Tp 단백 Tp47、Tp45화Tp15가작위조기매독진단적지표;재각기표체유명현차이적Tp41、Tp37화Tp33가고필작위림상분기관찰지표;Tp45、Tp41、Tp17화Tp15가작위이후림상치료효과적보조진단삼고。
Objective:To analysis the differences expression of IgG, IgA and IgM antibody in Syphilis patients before treatment.Methods:The serum of IgG, IgA and IgM antibody in 34 pa-tients with syphilis ( primary syphilis 8 cases, secondary syphilis 15 cases, tertiary syphilis 11cases) were measured by western blotting before treatment.Results:The positive rate of IgG Tp47, Tp45, Tp34 and Tp15 antibody were all 100%in different stages of syphilis.However, the positive rate of Tp33 antibody in tertiary syphilis (63.6%) was less than primary and secondary syphilis patients ( P =0.009 ); There were no significant difference in IgA antibody among the three stage of syphilis.Besides, no positive cases of Tp41, Tp34, Tp33, Tp30 in primary syphilis and Tp33 antibody band in tertiary syphilis were found;The expression of IgA Tp41 and Tp37 an-tibody have statistically significant difference among the three stage of syphilis ( P =0.035 and P=0.020) .Conclusion:Tp47、TP45 and TP15 could be used as indicators of diagnosis for pri-mary syphilis.Tp41, Tp37 and Tp33 could be considered as indicators for clinical stage of syphi-lis.Tp45, Tp41, Tp17 and Tp15 could be used as diagnostic reference for clinical efficacy.