CAJ | 학술논문

目的：观察经桡动脉介入治疗时应用阿托伐他汀钙片联合地尔硫卓针预防桡动脉痉挛（ RAS）的疗效，及对血压、心率的影响，进一步了解阿托伐他汀钙和地尔硫卓联合应用在预防桡动脉痉挛的安全性和有效性。方法：378例经桡动脉路径行冠脉介入治疗的患者，随机分为阿托伐他汀钙和地尔硫卓（130例），阿托伐他汀钙组（120例）和地尔硫卓组（128例），术前6 h口服阿托伐他汀钙片80 mg，成功置入6F动脉鞘管后以“弹丸式”注入地尔硫卓针，分别记录注入药物前，注入后1、3、5、10及30 min的血压、心率，观察局部及全身情况变化。结果：阿托伐他汀钙和地尔硫卓联合组局部及全身情况与对照组相比均无明显差异，三组对血压、心率的影响比较，差异无统计学意义（均P＞0.05）。阿托伐他汀钙联合地尔硫卓组有4例发生桡动脉痉挛，地尔硫卓组有12例，而阿托伐他汀钙组有16例，三组相比，差异有显著统计学意义（χ2值：4.9926，P值＜0.05，χ2值：8.0085，P值＜0.01）。结论：经桡动脉介入治疗时，阿托伐他汀钙和地尔硫卓联合应用可以有效预防桡动脉痉挛的发生，且对心率、血压无明显影响。
목적：관찰경뇨동맥개입치료시응용아탁벌타정개편연합지이류탁침예방뇨동맥경련（ RAS）적료효，급대혈압、심솔적영향，진일보료해아탁벌타정개화지이류탁연합응용재예방뇨동맥경련적안전성화유효성。방법：378례경뇨동맥로경행관맥개입치료적환자，수궤분위아탁벌타정개화지이류탁（130례），아탁벌타정개조（120례）화지이류탁조（128례），술전6 h구복아탁벌타정개편80 mg，성공치입6F동맥초관후이“탄환식”주입지이류탁침，분별기록주입약물전，주입후1、3、5、10급30 min적혈압、심솔，관찰국부급전신정황변화。결과：아탁벌타정개화지이류탁연합조국부급전신정황여대조조상비균무명현차이，삼조대혈압、심솔적영향비교，차이무통계학의의（균P＞0.05）。아탁벌타정개연합지이류탁조유4례발생뇨동맥경련，지이류탁조유12례，이아탁벌타정개조유16례，삼조상비，차이유현저통계학의의（χ2치：4.9926，P치＜0.05，χ2치：8.0085，P치＜0.01）。결론：경뇨동맥개입치료시，아탁벌타정개화지이류탁연합응용가이유효예방뇨동맥경련적발생，차대심솔、혈압무명현영향。
Objective To observe the effect of application Atorvastatin Calcium Tablets combined diltiazem needle to prevent radial artery spasm percutaneous radial artery interventional therapy( RAS),and the influence on blood pressure,heart rate,and further understand the safety and efficacy of atorvastatin and diltiazem combined application in preventing radial artery spasm. Method 378 patients with interven-tional therapy through radial artery pathway for coronary artery were randomly divided into atorvastatin and diltiazem(130 cases),atorvastatin group(120 cases)and diltiazem group(128 cases),6 hours before the operation in oral Atorvastatin Calcium Tablets 80 mg,successful im-plantation of the 6F arterial sheath tube after the“bolus”injection of diltiazem were recorded before injection needle,injection drug,after 1, 3,5,10 and 30 min blood pressure,heart rate,observation of local and systemic changes. Results Atorvastatin calcium and diltiazem in combi-nation with local and systemic conditions compared with the control group had no difference,no significant difference between the three groups effect on blood pressure,heart rate( P>0. 05). Atorvastatin calcium combined with diltiazem group had 4 cases of radial artery spasm,dilti-azem group had 12 cases,and atorvastatin calcium group had 16 cases,there was significant difference between three groups(χ2:4. 992 6,P<0. 05,χ2:8. 0085,P<0. 01). Conclusion transradial coronary intervention of atorvastatin calcium,combined use of statins and Zhuo diltiazem can be effective in preventing radial artery spasm,and on heart rate,blood pressure has no obvious influence.