CAJ | 학술논문

目的分析妊娠哺乳期乳腺癌的临床特征及预后因素.方法回顾性分析天津市肿瘤医院2002年1月至2012年12月期间收治的77例患者的临床资料.根据发病时期将其分为妊娠期组(n=23)和哺乳期组(n=54).寿命表法计算生存率,COX比例风险回归模型进行多因素生存分析.结果全组肿瘤平均最大直径5.9cm,腋窝淋巴结阳性49例.与哺乳期乳腺癌患者相比,妊娠期乳腺癌患者肿瘤直径更大,平均为6.8 cm(P =0.031).中位随访时间39个月,5年无病生存率和5年总生存率分别为52.6％和61.8％.多因素分析显示,影响患者无病生存和总生存的独立预后因素均为哺乳与否和肿瘤大小.结论妊娠哺乳期乳腺癌延误诊断率高,TNM分期晚,预后较差,哺乳与否、肿瘤大小是影响患者预后的独立危险因素.
목적 분석임신포유기유선암적림상특정급예후인소.방법 회고성분석천진시종류의원2002년1월지2012년12월기간수치적77례환자적림상자료.근거발병시기장기분위임신기조(n=23)화포유기조(n=54).수명표법계산생존솔,COX비례풍험회귀모형진행다인소생존분석.결과 전조종류평균최대직경5.9cm,액와림파결양성49례.여포유기유선암환자상비,임신기유선암환자종류직경경대,평균위6.8 cm(P =0.031).중위수방시간39개월,5년무병생존솔화5년총생존솔분별위52.6％화61.8％.다인소분석현시,영향환자무병생존화총생존적독립예후인소균위포유여부화종류대소.결론 임신포유기유선암연오진단솔고,TNM분기만,예후교차,포유여부、종류대소시영향환자예후적독립위험인소.
Objective To explore the clinical features and prognostic factors of breast cancer during pregnancy and lactation.Methods A retrospective analysis was performed on 77 patients admitted to the Tianjin Cancer Hospital from January 2002 to December 2012.According to when the cancer was found,these patients were divided into the pregnancy group (n =23) and the lactation group (n =54).Survival rate was calculated by life table,Multivariate factors for survival were analyzed by COX proportional hazards regression model.Results The mean maximum diameter of the tumor was 5.9 cm,49 cases had axillary lymph node metastasis.Compared with the lactation group,the patients in pregnancy group had larger tumor diameter,the mean diameter was 6.8 cm (P =0.031).The median follow-up time was 39 months and 5-year disease-free survival (DFS) rate and 5-year overall survival (OS) rate were 52.6％ and 61.8％,respectively.Multivariate analysis showed that the independent factors of DFS and OS were breastfeeding and tumor size.Conclusions Diagnosis of breast cancer daring pregnancy and lactation were usually delayed and often in late TNM stage.Breastfeeding and tumor size are independent prognostic factors.