泰山医学院学报
泰山醫學院學報
태산의학원학보
JOURNAL OF TAISHAN MEDICAL COLLEGE
2015年
2期
150-152
,共3页
支气管哮喘%强的松%孟鲁斯特%茶碱缓释片%急性发作
支氣管哮喘%彊的鬆%孟魯斯特%茶堿緩釋片%急性髮作
지기관효천%강적송%맹로사특%다감완석편%급성발작
asthma%prednisone%montelukast%theophylline%exacerbations
目的：探讨强的松片联合孟鲁司特及小剂量茶碱缓释片口服治疗成人支气管哮喘中度急性发作的疗效。方法90例哮喘中度急性发作患者随机分成实验组、对照组各45例。两组患者均于接诊第1天予氨茶碱0.25 g 加入250 ml 的5％葡萄糖注射液中进行静脉滴注1次及甲基强的松龙40 mg 加入100 ml 的0.9％氯化钠注射液中进行静脉滴注1次；每日雾化吸入可必特液2.5 ml/次，2次/ d。实验组，30 mg 强的松片每日顿服、孟鲁司特10 mg 每晚1次口服及茶碱缓释片0.1 q 12 h；对照组，30 mg 强的松片每日顿服及孟鲁司特10 mg 每晚1次口服。两组均治疗7天。比较两组患者的临床疗效及不良反应。结果（1）实验组治疗后总有效率为97.8％；对照组治疗后总有效率为82.2％。实验组总有效率高于对照组，差异有统计学意义（P ＜0.05）；（2）实验组临床症状及体征缓解的时间均明显短于对照组，差异有统计学意义（ P ＜0.05）；（3）两组治疗期间未见明显不良反应。结论强的松片联合孟鲁司特及小剂量茶碱缓释片口服治疗成人支气管哮喘中度急性发作疗效显著，值得临床推广应用。
目的：探討彊的鬆片聯閤孟魯司特及小劑量茶堿緩釋片口服治療成人支氣管哮喘中度急性髮作的療效。方法90例哮喘中度急性髮作患者隨機分成實驗組、對照組各45例。兩組患者均于接診第1天予氨茶堿0.25 g 加入250 ml 的5％葡萄糖註射液中進行靜脈滴註1次及甲基彊的鬆龍40 mg 加入100 ml 的0.9％氯化鈉註射液中進行靜脈滴註1次；每日霧化吸入可必特液2.5 ml/次，2次/ d。實驗組，30 mg 彊的鬆片每日頓服、孟魯司特10 mg 每晚1次口服及茶堿緩釋片0.1 q 12 h；對照組，30 mg 彊的鬆片每日頓服及孟魯司特10 mg 每晚1次口服。兩組均治療7天。比較兩組患者的臨床療效及不良反應。結果（1）實驗組治療後總有效率為97.8％；對照組治療後總有效率為82.2％。實驗組總有效率高于對照組，差異有統計學意義（P ＜0.05）；（2）實驗組臨床癥狀及體徵緩解的時間均明顯短于對照組，差異有統計學意義（ P ＜0.05）；（3）兩組治療期間未見明顯不良反應。結論彊的鬆片聯閤孟魯司特及小劑量茶堿緩釋片口服治療成人支氣管哮喘中度急性髮作療效顯著，值得臨床推廣應用。
목적：탐토강적송편연합맹로사특급소제량다감완석편구복치료성인지기관효천중도급성발작적료효。방법90례효천중도급성발작환자수궤분성실험조、대조조각45례。량조환자균우접진제1천여안다감0.25 g 가입250 ml 적5％포도당주사액중진행정맥적주1차급갑기강적송룡40 mg 가입100 ml 적0.9％록화납주사액중진행정맥적주1차；매일무화흡입가필특액2.5 ml/차，2차/ d。실험조，30 mg 강적송편매일돈복、맹로사특10 mg 매만1차구복급다감완석편0.1 q 12 h；대조조，30 mg 강적송편매일돈복급맹로사특10 mg 매만1차구복。량조균치료7천。비교량조환자적림상료효급불량반응。결과（1）실험조치료후총유효솔위97.8％；대조조치료후총유효솔위82.2％。실험조총유효솔고우대조조，차이유통계학의의（P ＜0.05）；（2）실험조림상증상급체정완해적시간균명현단우대조조，차이유통계학의의（ P ＜0.05）；（3）량조치료기간미견명현불량반응。결론강적송편연합맹로사특급소제량다감완석편구복치료성인지기관효천중도급성발작료효현저，치득림상추엄응용。
Objective:To investigate the clinical efficacy of prednisone combined with montelukast and small - dose the-ophylline sustained - release tablets for treatment of bronchial asthma in aldults with medium acute exacerbations. Methods:90 cases with medium acute exacerbations of bronchial asthma were randomly divided into the experimental group (45cases)and the control group(45cases). Both group were applicated with 0. 25 g aminophylline injection in 5% glu-cose 250 ml infusion once and 40 mg methylprednisolone injection in 0. 09% sodium chloride infusion 100 ml once by intra-venous drip on the first day and were given by atomization inhalation of Combivent 2. 5 ml,twice a day. The experimental group was treated with prednisone 30 mg once a day combined with montelukast 10mg once a day and theophylline sustained- release tablets 0. 1 per 12h;the control group was treated with prednisone 30 mg once a day and montelukast 10mg once a day . After 7 days,curative effect was compared in two groups . Results:(1)The total effective rate of the experimental group(97. 8% )was higher than that of the control group(82. 2% ),and There was statistical significant difference be-tween them(P < 0. 05). (2)The time needed to relieve the clinical symptoms and signs of the experimental group was shorten than that of the control group,and There was statistical significant difference between them(P < 0. 05).(3)There were no significant adverse reaction in two groups. Conclusions:Prednisone combined with montelukast and small - dose theophylline sustained - release tablets in treatment of bronchial asthma with medium acute exacerbations show significant clinical efficacy and it is worthy of popularization and application.
