CAJ | 학술논문

目的：探讨绝经后女性2型糖尿病及其合并高血压病患者血清雌激素水平的变化及其与胰岛素抵抗、血脂、血压的相关性，以便更好地指导临床纠正糖脂代谢紊乱、控制血压，缓解 IR，防止 IR 综合征的发生，延缓各种慢性并发症的发生和发展。方法将105名绝经后女性分为单纯糖尿病组45例，糖尿病合并高血压病组30例，正常对照组30名。检测各组年龄、空腹胰岛素（FINS）、雌二醇（E2）、空腹血糖（FPG）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL - C）、高密度脂蛋白胆固醇（HDL - C）、收缩压（SBP）、舒张压（DBP）、糖化血红蛋白（GHbA1c）、体重指数（BMI）。结果与正常对照组相比，两糖尿病组 FINS、TG、TC、LDL - C、SBP、DBP、GH-bA1c、HOMA - IR、BMI 均升高，E2均降低；糖尿病合并高血压病组与单纯糖尿病组比较 E2下降，FINS、SBP、DBP、HOMA - IR 均升高。相关分析显示，E2与 FINS、TC、LDL - C、HOMA - IR、SBP、BMI 相关；HOMA - IR 与 TG、TC 、LDL - C、BMI 相关。结论雌激素水平异常与绝经后女性2型糖尿病、胰岛素抵抗、血脂异常、高血压等代谢紊乱的发生、发展相关。
목적：탐토절경후녀성2형당뇨병급기합병고혈압병환자혈청자격소수평적변화급기여이도소저항、혈지、혈압적상관성，이편경호지지도림상규정당지대사문란、공제혈압，완해 IR，방지 IR 종합정적발생，연완각충만성병발증적발생화발전。방법장105명절경후녀성분위단순당뇨병조45례，당뇨병합병고혈압병조30례，정상대조조30명。검측각조년령、공복이도소（FINS）、자이순（E2）、공복혈당（FPG）、감유삼지（TG）、총담고순（TC）、저밀도지단백담고순（LDL - C）、고밀도지단백담고순（HDL - C）、수축압（SBP）、서장압（DBP）、당화혈홍단백（GHbA1c）、체중지수（BMI）。결과여정상대조조상비，량당뇨병조 FINS、TG、TC、LDL - C、SBP、DBP、GH-bA1c、HOMA - IR、BMI 균승고，E2균강저；당뇨병합병고혈압병조여단순당뇨병조비교 E2하강，FINS、SBP、DBP、HOMA - IR 균승고。상관분석현시，E2여 FINS、TC、LDL - C、HOMA - IR、SBP、BMI 상관；HOMA - IR 여 TG、TC 、LDL - C、BMI 상관。결론자격소수평이상여절경후녀성2형당뇨병、이도소저항、혈지이상、고혈압등대사문란적발생、발전상관。
Objective:To study the changes of levels in serum estrogen for postmenopausal women with type 2 diabetes mellitus(T2DM)or postmenopausal women with T2DM and EH,as well as the relationships with insulin resistance、Blood Lipids、blood pressure,in order to provid a better clinical guidance to control blood pressure and correct glycolipid metabolic disorder,alleviate insulin resistance and prevent the occurrence of insulin resistance syndrome,delay the occurrence and de-velopment of chronic complication. Methods:105 Postmenopausal women were divided into 3 groups:merely T2DM group of 45 patients,30 cases of T2DM with EH group,30 healthy controls. Each age,fasting insulin(FINS),estradiol(E2), FPG,HbA1c,TG,TC,LDL - C,HDL - C,SBP,DBP,GHbA1c and BMI were measured . Results:Compared with the control group,the two diabetes groups had higher FINS、TG、TC、LDL - C、SBP、DBP、GHbA1c、HOMA - IR、BMI and lower E2. T2DM with EH group had lower E2 and higher FINS、SBP、DBP、HOMA - IR than merely T2DM group. Correlation a-nalysis showed that E2 was related with FINS、TC、LDL - C、HOMA - IR、SBP BMI and HOMA - IR was related with TG、TC 、LDL - C、BMI.Conclusions:The occurrence and development of type 2 diabetes,IR,dyslipidemia and EH in Postm-enopausal women is related with abnormal estrogen levels.