中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2015年
3期
236-239
,共4页
非增殖期糖尿病视网膜病变%糖尿病性黄斑水肿%微动脉瘤
非增殖期糖尿病視網膜病變%糖尿病性黃斑水腫%微動脈瘤
비증식기당뇨병시망막병변%당뇨병성황반수종%미동맥류
Non-proliferative diabetic retinopathy%Diabetic macular edema%Microaneurysm
目的 观察非增殖期糖尿病视网膜病变(NPDR)各分期中糖尿病性黄斑水肿(DME)的发生率,研究DME与NPDR病变程度是否平行,了解NPDR眼底病变与DME之间的关系.方法 临床病例系列研究.对2013年1月至2014年6月在内蒙古民族大学附属医院确诊NPDR 120例(186只眼)患者分析,统计DME在NPDR各分期中的发生率,研究NPDR病变程度与DME发生的相关性;应用多因素方差分析和Logistic回归分析,探讨DME的发生与微动脉瘤(MA)、视网膜点状出血、渗出的关系.结果 120例(186只眼)NPDR患者中,发生DME 52例(87只眼),其中轻度NPDR12例(20只眼),按眼数比占22.99％ (20/87),中度NPDR19例(28只眼),占32.18％ (28/87),重度NPDR21例(39只眼),占44.83％ (39/87),三组间差异无统计学意义(x2=0.57,P=0.75).经过多因素方差分析视网膜微动脉瘤对于DME的影响显著差异有统计学意义(F =11.77,P=0.001),出血和渗出的影响并不显著,差异无统计学意义(F =3.69,P=0.056;F=1.704,P=0.193).进一步的Logistic回归分析结果发现,只有微动脉瘤变量是独立性危险因素.结论 NPDR患者出现DME与NPDR的病变程度并不平行;微动脉瘤是NPDR患者发生DME的独立危险因素.
目的 觀察非增殖期糖尿病視網膜病變(NPDR)各分期中糖尿病性黃斑水腫(DME)的髮生率,研究DME與NPDR病變程度是否平行,瞭解NPDR眼底病變與DME之間的關繫.方法 臨床病例繫列研究.對2013年1月至2014年6月在內矇古民族大學附屬醫院確診NPDR 120例(186隻眼)患者分析,統計DME在NPDR各分期中的髮生率,研究NPDR病變程度與DME髮生的相關性;應用多因素方差分析和Logistic迴歸分析,探討DME的髮生與微動脈瘤(MA)、視網膜點狀齣血、滲齣的關繫.結果 120例(186隻眼)NPDR患者中,髮生DME 52例(87隻眼),其中輕度NPDR12例(20隻眼),按眼數比佔22.99％ (20/87),中度NPDR19例(28隻眼),佔32.18％ (28/87),重度NPDR21例(39隻眼),佔44.83％ (39/87),三組間差異無統計學意義(x2=0.57,P=0.75).經過多因素方差分析視網膜微動脈瘤對于DME的影響顯著差異有統計學意義(F =11.77,P=0.001),齣血和滲齣的影響併不顯著,差異無統計學意義(F =3.69,P=0.056;F=1.704,P=0.193).進一步的Logistic迴歸分析結果髮現,隻有微動脈瘤變量是獨立性危險因素.結論 NPDR患者齣現DME與NPDR的病變程度併不平行;微動脈瘤是NPDR患者髮生DME的獨立危險因素.
목적 관찰비증식기당뇨병시망막병변(NPDR)각분기중당뇨병성황반수종(DME)적발생솔,연구DME여NPDR병변정도시부평행,료해NPDR안저병변여DME지간적관계.방법 림상병례계렬연구.대2013년1월지2014년6월재내몽고민족대학부속의원학진NPDR 120례(186지안)환자분석,통계DME재NPDR각분기중적발생솔,연구NPDR병변정도여DME발생적상관성;응용다인소방차분석화Logistic회귀분석,탐토DME적발생여미동맥류(MA)、시망막점상출혈、삼출적관계.결과 120례(186지안)NPDR환자중,발생DME 52례(87지안),기중경도NPDR12례(20지안),안안수비점22.99％ (20/87),중도NPDR19례(28지안),점32.18％ (28/87),중도NPDR21례(39지안),점44.83％ (39/87),삼조간차이무통계학의의(x2=0.57,P=0.75).경과다인소방차분석시망막미동맥류대우DME적영향현저차이유통계학의의(F =11.77,P=0.001),출혈화삼출적영향병불현저,차이무통계학의의(F =3.69,P=0.056;F=1.704,P=0.193).진일보적Logistic회귀분석결과발현,지유미동맥류변량시독립성위험인소.결론 NPDR환자출현DME여NPDR적병변정도병불평행;미동맥류시NPDR환자발생DME적독립위험인소.
Objective To analyze the incidence of diabetic macular edema (DME) in each stage of non-proliferative diabetic retinopathy (NPDR) and to investigate the relationship between DME and the retinal signs,so that to clarify the risk factors of DME in NPDR.Methods The data of 120 NPDR cases (186 eyes),which diagnosed by fundus fluorescein angiography (FFA),from the ophthalmology department of the Affiliated Hospital of Inner Mongolia University for Nationalities were collected.Then the relationship between the extent of NPDR and the occurrence of DME was determined by investigating the incidence of DME in various stages of NPDR.These subjects were divided into two groups according to the DME appearance or not,and then the logistic regression analysis was applied to explore the correlation between the incidence of DME and the retinal signs (including retinal spotting,exudation,microangioma).Results There were 52 patients (87eyes) suffered from DME in these subjects:12 cases (20 eyes) in mild NPDR,19 cases (28 eyes) in moderate NPDR,21 cases (39 eyes) in severe NPDR,and no statistically significant difference was found among these groups (x2=0.57,P =0.75).The retinal microaneurysm was perceived to be an independent risk factor for the occurrence of DME (F =11.77,P =0.001),and retinal bleeding and exudation with were found no significant relationship to the incidence of DME (F =3.69,P =0.056;F =1.704,P =0.193) after a multi-factor analysis of variance and Logistic regression analysis.Conclusions The NPDR severity is not parallel to the occurrence of DME.Retinal microaneurysm is an independent risk factor for the occurrence of DME in NPDR patients.
