中华眼底病杂志
中華眼底病雜誌
중화안저병잡지
CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
2015年
2期
139-142
,共4页
程金涛%戚金泽%梁佳美%张庆芬
程金濤%慼金澤%樑佳美%張慶芬
정금도%척금택%량가미%장경분
糖尿病视网膜病变/病因学%血脂异常/代谢%脂肪因子类
糖尿病視網膜病變/病因學%血脂異常/代謝%脂肪因子類
당뇨병시망막병변/병인학%혈지이상/대사%지방인자류
Diabetic retinopathy/etiology%Dyslipidemias/metabolism%Adipokines
目的 观察糖尿病视网膜病变(DR)患者血清apelin与血脂水平.方法 临床检查确诊的2型糖尿病(T2DM)患者90例纳入研究.均行视力、裂隙灯显微镜、间接检眼镜、荧光素眼底血管造影检查.根据检查结果,按美国眼科学会DR临床分期标准,将患者分为无DR (NDR)组、非增生型DR(NPDR)组、增生型DR(PDR)组.每组均为30例.选择同期健康体检者30名作为对照组.4组受检者年龄(F=0.564),身高(F=0.332)、体重(F=0.336)、体重指数(F=0.297)比较,差异均无统计学意义(P＞0.05).采用全自动生化分析仪测定受检者血清胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDLC)、低密度脂蛋白(LDLC)、糖化血红蛋白(HbA1c)水平;酶联免疫吸附试验测定血清中apelin水平.HbA1c、TC、TG、HDLC、LDLC、apelin与DR严重程度的相关性行多因素相关分析;与DR分期行直线相关分析.结果 NDR组、NPDR组、PDR组、对照组受检者血清HbA1c(F=403.06)、TC(F=5.45)、HDLC(F=4.27)、LDLC(F=4.90)、apelin(F=201.56)水平比较,差异均有统计学意义(P＜0.05);血清TG水平比较,差异无统计学意义(F=2.19,P＞0.05).NDR组、NPDR组、PDR组血清HbA1c、TC、LDLC、apelin水平较对照组显著性升高,差异有统计学意义(t=0.30、0.58、0.79,P＜0.05);HDLC水平较对照组显著降低,差异有统计学意义(t=0.79,P＜0.01).DR分期与HbA1c、LDLC、apelin显著相关(r=0.962、0.562、0.935,P＜0.05);与HDLC的下降极显著相关(r=-0.753,P＜0.01).Apelin与HbA2c、LDLC有极显著相关性(r=0.956、0.741,P＜0.01);与HDLC呈负相关(r=-0.691,P＜0.01).结论 DR患者血清中apelin水平明显升高,并且与血糖、血脂代谢异常密切相关.
目的 觀察糖尿病視網膜病變(DR)患者血清apelin與血脂水平.方法 臨床檢查確診的2型糖尿病(T2DM)患者90例納入研究.均行視力、裂隙燈顯微鏡、間接檢眼鏡、熒光素眼底血管造影檢查.根據檢查結果,按美國眼科學會DR臨床分期標準,將患者分為無DR (NDR)組、非增生型DR(NPDR)組、增生型DR(PDR)組.每組均為30例.選擇同期健康體檢者30名作為對照組.4組受檢者年齡(F=0.564),身高(F=0.332)、體重(F=0.336)、體重指數(F=0.297)比較,差異均無統計學意義(P＞0.05).採用全自動生化分析儀測定受檢者血清膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDLC)、低密度脂蛋白(LDLC)、糖化血紅蛋白(HbA1c)水平;酶聯免疫吸附試驗測定血清中apelin水平.HbA1c、TC、TG、HDLC、LDLC、apelin與DR嚴重程度的相關性行多因素相關分析;與DR分期行直線相關分析.結果 NDR組、NPDR組、PDR組、對照組受檢者血清HbA1c(F=403.06)、TC(F=5.45)、HDLC(F=4.27)、LDLC(F=4.90)、apelin(F=201.56)水平比較,差異均有統計學意義(P＜0.05);血清TG水平比較,差異無統計學意義(F=2.19,P＞0.05).NDR組、NPDR組、PDR組血清HbA1c、TC、LDLC、apelin水平較對照組顯著性升高,差異有統計學意義(t=0.30、0.58、0.79,P＜0.05);HDLC水平較對照組顯著降低,差異有統計學意義(t=0.79,P＜0.01).DR分期與HbA1c、LDLC、apelin顯著相關(r=0.962、0.562、0.935,P＜0.05);與HDLC的下降極顯著相關(r=-0.753,P＜0.01).Apelin與HbA2c、LDLC有極顯著相關性(r=0.956、0.741,P＜0.01);與HDLC呈負相關(r=-0.691,P＜0.01).結論 DR患者血清中apelin水平明顯升高,併且與血糖、血脂代謝異常密切相關.
목적 관찰당뇨병시망막병변(DR)환자혈청apelin여혈지수평.방법 림상검사학진적2형당뇨병(T2DM)환자90례납입연구.균행시력、렬극등현미경、간접검안경、형광소안저혈관조영검사.근거검사결과,안미국안과학회DR림상분기표준,장환자분위무DR (NDR)조、비증생형DR(NPDR)조、증생형DR(PDR)조.매조균위30례.선택동기건강체검자30명작위대조조.4조수검자년령(F=0.564),신고(F=0.332)、체중(F=0.336)、체중지수(F=0.297)비교,차이균무통계학의의(P＞0.05).채용전자동생화분석의측정수검자혈청담고순(TC)、감유삼지(TG)、고밀도지단백(HDLC)、저밀도지단백(LDLC)、당화혈홍단백(HbA1c)수평;매련면역흡부시험측정혈청중apelin수평.HbA1c、TC、TG、HDLC、LDLC、apelin여DR엄중정도적상관성행다인소상관분석;여DR분기행직선상관분석.결과 NDR조、NPDR조、PDR조、대조조수검자혈청HbA1c(F=403.06)、TC(F=5.45)、HDLC(F=4.27)、LDLC(F=4.90)、apelin(F=201.56)수평비교,차이균유통계학의의(P＜0.05);혈청TG수평비교,차이무통계학의의(F=2.19,P＞0.05).NDR조、NPDR조、PDR조혈청HbA1c、TC、LDLC、apelin수평교대조조현저성승고,차이유통계학의의(t=0.30、0.58、0.79,P＜0.05);HDLC수평교대조조현저강저,차이유통계학의의(t=0.79,P＜0.01).DR분기여HbA1c、LDLC、apelin현저상관(r=0.962、0.562、0.935,P＜0.05);여HDLC적하강겁현저상관(r=-0.753,P＜0.01).Apelin여HbA2c、LDLC유겁현저상관성(r=0.956、0.741,P＜0.01);여HDLC정부상관(r=-0.691,P＜0.01).결론 DR환자혈청중apelin수평명현승고,병차여혈당、혈지대사이상밀절상관.
Objective To investigate the role of apelin,glycosylated hemoglobin (HbAlc),cholesterol (TC),triglyceride (TG),High density lipoprotein cholesterol (HDLC),low density lipoprotein cholesterol (LDLC) in the development and progress of diabetic retinopathy (DR).Methods The serum concentration of apelin,HbA1c,TC,TG,HDLC and LDLC were measured in 30 normal control subjects and 90 patients with type 2 diabetic mellitus,including 30 cases without DR (NDR),30 with non-proliferative DR (NPDR),30 with proliferative DR (PDR).These data were analyzed by SPSS for windows 13.0.Results The serum concentration of apelin,HbAlc,TC,HDLC,LDLC were significantly higher in NDR,NPDR,PDR group than those in control group (F=403.06,5.45,4.27,201.56,4.90;P＜0.05).The serum concentration of TG has no significantly difference (F=2.19,P＞0.05).The serum concentration of apelin,HbA1c,TC,LDLC were significantly higher in NDR,NPDR,PDR group than those in control group (t =0.30,0.58,0.79;P ＜ 0.05),the serum concentration of HDLC were significantly lower than those in control group(t=0.79,P＜0.01).There were significantly positive correlation between the progression of DR and the serum concentration of apelin,HbA1c,TC,LDLC(r=0.962,0.562,0.935;P＜0.05).There were significantly negative correlation between the progression of DR and the serum concentration of HDLC(r=-0.753,P＜0.01).There were correlation between apelin and HbA1c,LDLC and HDLC(r=0.956,0.741,-0.691;P＜0.01).Conclusion Our data demonstrated that serum apelin levels increased significantly in patients with diabetic retinopathy,and are closely related to blood sugar,blood lipid metabolic abnormalities.
