国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2015年
4期
643-645
,共3页
糖尿病视网膜病变%血小板分布宽度%纤维蛋白原
糖尿病視網膜病變%血小闆分佈寬度%纖維蛋白原
당뇨병시망막병변%혈소판분포관도%섬유단백원
diabetic retinopathy%platelet distribution width%fibrinogen
目的：明确血小板分布宽度( platelet distribution width, PDW)及纤维蛋白原( fibrinogen,FIB)与糖尿病视网膜病变( diabetic retinopathy,DR)严重程度之间的关系。<br> 方法：选取2012-06/2014-05在我院眼科及内分泌科住院的DR患者99例(非增殖期48例,增殖期51例),同时选取50例无DR糖尿病患者和50例无糖尿病健康人进行对照。采集基本资料,抽空腹血行PDW、FIB、血小板计数、空腹血糖及糖化血红蛋白(HbA1c)等检查。<br> 结果：糖尿病各组人群 PDW 水平显著高于健康对照组(16.6%±1.2%)(P<0.05),且随DR病变分级的增加, PDW 水平显著增加,分别为17.6%±1.8%,19.1%±2.1%,20%±1.9%,差异有统计学意义(均为P<0.05)。糖尿病各组FIB水平也显著高于健康对照组( P<0.05)。多因素Logistic回归分析显示,在校正年龄、性别、病程及糖化血红蛋白等因素后,随着PDW及FIB水平升高,非增殖期(OR：1.464,PDW)(OR：2.199,FIB)和增殖期DR (OR：1.652,PDW)(OR：2.691,FIB)的患病风险显著增加(均为P<0.05)。<br> 结论：PDW和FIB水平随DR严重程度升高而增加,非增殖期和增殖期DR患病风险随PDW及FIB水平升高而增加。
目的：明確血小闆分佈寬度( platelet distribution width, PDW)及纖維蛋白原( fibrinogen,FIB)與糖尿病視網膜病變( diabetic retinopathy,DR)嚴重程度之間的關繫。<br> 方法：選取2012-06/2014-05在我院眼科及內分泌科住院的DR患者99例(非增殖期48例,增殖期51例),同時選取50例無DR糖尿病患者和50例無糖尿病健康人進行對照。採集基本資料,抽空腹血行PDW、FIB、血小闆計數、空腹血糖及糖化血紅蛋白(HbA1c)等檢查。<br> 結果：糖尿病各組人群 PDW 水平顯著高于健康對照組(16.6%±1.2%)(P<0.05),且隨DR病變分級的增加, PDW 水平顯著增加,分彆為17.6%±1.8%,19.1%±2.1%,20%±1.9%,差異有統計學意義(均為P<0.05)。糖尿病各組FIB水平也顯著高于健康對照組( P<0.05)。多因素Logistic迴歸分析顯示,在校正年齡、性彆、病程及糖化血紅蛋白等因素後,隨著PDW及FIB水平升高,非增殖期(OR：1.464,PDW)(OR：2.199,FIB)和增殖期DR (OR：1.652,PDW)(OR：2.691,FIB)的患病風險顯著增加(均為P<0.05)。<br> 結論：PDW和FIB水平隨DR嚴重程度升高而增加,非增殖期和增殖期DR患病風險隨PDW及FIB水平升高而增加。
목적：명학혈소판분포관도( platelet distribution width, PDW)급섬유단백원( fibrinogen,FIB)여당뇨병시망막병변( diabetic retinopathy,DR)엄중정도지간적관계。<br> 방법：선취2012-06/2014-05재아원안과급내분비과주원적DR환자99례(비증식기48례,증식기51례),동시선취50례무DR당뇨병환자화50례무당뇨병건강인진행대조。채집기본자료,추공복혈행PDW、FIB、혈소판계수、공복혈당급당화혈홍단백(HbA1c)등검사。<br> 결과：당뇨병각조인군 PDW 수평현저고우건강대조조(16.6%±1.2%)(P<0.05),차수DR병변분급적증가, PDW 수평현저증가,분별위17.6%±1.8%,19.1%±2.1%,20%±1.9%,차이유통계학의의(균위P<0.05)。당뇨병각조FIB수평야현저고우건강대조조( P<0.05)。다인소Logistic회귀분석현시,재교정년령、성별、병정급당화혈홍단백등인소후,수착PDW급FIB수평승고,비증식기(OR：1.464,PDW)(OR：2.199,FIB)화증식기DR (OR：1.652,PDW)(OR：2.691,FIB)적환병풍험현저증가(균위P<0.05)。<br> 결론：PDW화FIB수평수DR엄중정도승고이증가,비증식기화증식기DR환병풍험수PDW급FIB수평승고이증가。
AIM: To define the relationship between platelet distribution width ( PDW) , fibrinogen ( FIB) and severity of diabetic retinopathy ( DR) . <br> METHODS: The survey included 99 patients with DR (48 with non-proliferative and 51 with proliferative DR) in our hospital during June 2012 and May 2014. Another 50 diabetic patients without DR and 50 healthy volunteers were matched as controls. Demographic data and disease history were gained. Fasting blood sample were collected to measure PDW, FIB, platelet count, fasting blood glucose and HbA1c. <br> RESULTS: Compared with healthy controls ( 16. 6%±1.2%) , a significant difference was found in PDW values among diabetic patients ( all P < 0. 05 ). The higher development of DR corresponded with a significantly higher level of PDW 17. 6%±1. 8%, 19. 1%±2. 1%, and 20%±1. 9% for patients without DR, non-proliferative DR and proliferative DR, respectively, the difference had statistical significance (P<0. 05). A significant difference was also found in FIB values among diabetic patients and healthy controls (P<0. 05). After correction for age, <br> gender, disease duration and HbA1c, multi factor Logistic analysis showed that there were significant increased risks in the prevalence of non-proliferative ( OR: 1. 464, PDW) ( OR: 2. 199, FIB) and proliferative DR ( OR: 1. 652, PDW ) ( OR: 2. 691, FIB ) with the increased PDW and FIB value (all P<0. 05). <br> CONCLUSION: The PDW and FIB value are parallel with the severity of DR, and there is increased risk of non-proliferative and proliferative DR with the PDW and FIB value increases.
