中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2015年
4期
293-296
,共4页
张艳琦%张丽娜%顾林
張豔琦%張麗娜%顧林
장염기%장려나%고림
乳腺肿瘤%癌,鳞状细胞%病理学,临床%诊断%治疗%预后
乳腺腫瘤%癌,鱗狀細胞%病理學,臨床%診斷%治療%預後
유선종류%암,린상세포%병이학,림상%진단%치료%예후
Breast neoplasms%Carcinoma,squamous cell%Pathology,clinical%Diagnosis%Therapy%Prognosis
目的：探讨乳腺原发性鳞状细胞癌的临床病理特征和预后。方法回顾性分析1985年1月至2011年1月诊治的22例乳腺原发性鳞状细胞癌的临床资料，分析患者的临床病理特征与预后的关系。采用Cox比例风险回归模型分析影响患者预后的因素。结果22例乳腺原发性鳞状细胞癌患者均为女性，中位年龄为56岁。平均肿瘤最大直径为3．6 cm。雌激素受体、孕激素受体和人表皮生长因子受体2的阳性表达率分别为9．1％、9．1％和33．3％。5例患者发生复发或转移，均因肿瘤复发转移死亡。22例患者的中位生存时间为60个月，5年生存率为73．6％。单因素分析结果显示，肿瘤最大直径和腋下淋巴结转移是影响患者预后的因素（均P＜0．05），而患者绝经与否、化疗和放疗与预后无关（均P＞0．05）。多因素分析结果显示，肿瘤最大直径和腋下淋巴结转移是影响患者预后的独立因素（均P＜0．05）。结论乳腺原发性鳞状细胞癌的发病率低，临床特征缺乏特异性。腋下淋巴结转移是影响患者预后的独立因素。
目的：探討乳腺原髮性鱗狀細胞癌的臨床病理特徵和預後。方法迴顧性分析1985年1月至2011年1月診治的22例乳腺原髮性鱗狀細胞癌的臨床資料，分析患者的臨床病理特徵與預後的關繫。採用Cox比例風險迴歸模型分析影響患者預後的因素。結果22例乳腺原髮性鱗狀細胞癌患者均為女性，中位年齡為56歲。平均腫瘤最大直徑為3．6 cm。雌激素受體、孕激素受體和人錶皮生長因子受體2的暘性錶達率分彆為9．1％、9．1％和33．3％。5例患者髮生複髮或轉移，均因腫瘤複髮轉移死亡。22例患者的中位生存時間為60箇月，5年生存率為73．6％。單因素分析結果顯示，腫瘤最大直徑和腋下淋巴結轉移是影響患者預後的因素（均P＜0．05），而患者絕經與否、化療和放療與預後無關（均P＞0．05）。多因素分析結果顯示，腫瘤最大直徑和腋下淋巴結轉移是影響患者預後的獨立因素（均P＜0．05）。結論乳腺原髮性鱗狀細胞癌的髮病率低，臨床特徵缺乏特異性。腋下淋巴結轉移是影響患者預後的獨立因素。
목적：탐토유선원발성린상세포암적림상병리특정화예후。방법회고성분석1985년1월지2011년1월진치적22례유선원발성린상세포암적림상자료，분석환자적림상병리특정여예후적관계。채용Cox비례풍험회귀모형분석영향환자예후적인소。결과22례유선원발성린상세포암환자균위녀성，중위년령위56세。평균종류최대직경위3．6 cm。자격소수체、잉격소수체화인표피생장인자수체2적양성표체솔분별위9．1％、9．1％화33．3％。5례환자발생복발혹전이，균인종류복발전이사망。22례환자적중위생존시간위60개월，5년생존솔위73．6％。단인소분석결과현시，종류최대직경화액하림파결전이시영향환자예후적인소（균P＜0．05），이환자절경여부、화료화방료여예후무관（균P＞0．05）。다인소분석결과현시，종류최대직경화액하림파결전이시영향환자예후적독립인소（균P＜0．05）。결론유선원발성린상세포암적발병솔저，림상특정결핍특이성。액하림파결전이시영향환자예후적독립인소。
Objective To investigate the clinicopathological features and prognosis of primary squamous cell carcinoma of the breast and to improve the diagnosis, treatment and prognosis of this disease. Methods The clinicopathological data of 22 patients with primary squamous cell carcinoma of the breast treated in our hospital between January 1985 and January 2011 were retrospectively reviewed.The correlation between age, tumor size, axillary node status, treatment modality and prognosis was statistically analyzed. Results All the 22 patients were female and their median age was 56 years.The average tumor diameter was 3.6 cm.The diagnosis was confirmed by histopathology.The positive rates of expression of ER,PR and HER-2 of the breast cancers were 9.1%, 9.1% and 33.3%, respectively.In follow-up visits, recurrence or metastasis was found in 5 patients and they all died of it.The median overall survival of the 22 patients was 60 months and their overall 5-year survival rate was 73.6%.Univariate analysis showed that the tumor maximum diameter( P=0.024) and axillary lymph node status ( P=0.022) were impact factors, while menopause,chemotherapy and radiotherapy were not.Cox multivariate analysis showed that the tumor size (P=0.021) and axillary lymph node status (P=0.037) were independent prognostic factors for primary squamous cell carcinoma of the breast.Conclusions Primary squamous cell carcinoma of the breast is a rare entity and lack of specific clinical features.Axillary node status is an independent prognostic factor.
