CAJ | 학술논문

目的：分析1990年与2010年中国15岁以上人群慢性阻塞性肺疾病（COPD)的疾病负担变化情况。方法利用2010年全球疾病负担研究结果，分析1990年和2010年中国15岁以上人群COPD的死亡、患病情况，及其过早死亡损失寿命年（YLL)、伤残损失寿命年（YLD)及伤残调整寿命年（DALY),比较中国1990年和2010年COPD导致的DALY、标化死亡率和DALY率的变化情况。结果2010年我国15岁以上居民因COPD死亡的人数为93.4万例（男性53.4万例，女性40.0万例)，比1990年（142.5万例,男性70.5万例,女性72.0万例)减少34.5%(男性减少24.3%，女性减少44.4%)；2010年COPD的患病人数为4176.4万例（男性2211.1万例，女性1965.3万例)，比1990年（2938.2万例,男性1559.9万例,女性1378.3万例)增加了42.1%(男性增加41.7%，女性增加42.6%)。我国15岁以上居民COPD的标化死亡率由1990年的235.2/10万下降为2010年的90.5/10万，下降幅度达61.5%。我国1990年和2010年15岁以上居民COPD标化患病率分别为4.2%和3.9%。2010年我国因COPD造成的DALY、YLL和YLD分别为1659.8万、1294.6万及365.2万人年。与1990年（256.7万人年)相比，2010年我国因COPD造成的YLD上升了42.3%。标化YLL率由1990年的3756.9/10万下降为2010年的1235.6/10万，标化DALY率由1990年的4120.1/10万下降为2010年的1575.9/10万，标化YLD率由1990年的363.2/10万下降为2010年的340.3/10万。结论与1990年相比，虽然2010年COPD所致的DALY有了明显下降，但因伤残导致的疾病负担有所上升。
목적：분석1990년여2010년중국15세이상인군만성조새성폐질병（COPD)적질병부담변화정황。방법이용2010년전구질병부담연구결과，분석1990년화2010년중국15세이상인군COPD적사망、환병정황，급기과조사망손실수명년（YLL)、상잔손실수명년（YLD)급상잔조정수명년（DALY),비교중국1990년화2010년COPD도치적DALY、표화사망솔화DALY솔적변화정황。결과2010년아국15세이상거민인COPD사망적인수위93.4만례（남성53.4만례，녀성40.0만례)，비1990년（142.5만례,남성70.5만례,녀성72.0만례)감소34.5%(남성감소24.3%，녀성감소44.4%)；2010년COPD적환병인수위4176.4만례（남성2211.1만례，녀성1965.3만례)，비1990년（2938.2만례,남성1559.9만례,녀성1378.3만례)증가료42.1%(남성증가41.7%，녀성증가42.6%)。아국15세이상거민COPD적표화사망솔유1990년적235.2/10만하강위2010년적90.5/10만，하강폭도체61.5%。아국1990년화2010년15세이상거민COPD표화환병솔분별위4.2%화3.9%。2010년아국인COPD조성적DALY、YLL화YLD분별위1659.8만、1294.6만급365.2만인년。여1990년（256.7만인년)상비，2010년아국인COPD조성적YLD상승료42.3%。표화YLL솔유1990년적3756.9/10만하강위2010년적1235.6/10만，표화DALY솔유1990년적4120.1/10만하강위2010년적1575.9/10만，표화YLD솔유1990년적363.2/10만하강위2010년적340.3/10만。결론여1990년상비，수연2010년COPD소치적DALY유료명현하강，단인상잔도치적질병부담유소상승。
Objective To analyze the disease burden of chronic obstructive pulmonary disease (COPD) among people aged over 15 years in 1990 and 2010 in China. Methods The estimation of China data for the Global Burden of Disease Study 2010 (GBD 2010) was used to analyze the mortality and prevalence as well as the years of life lost due to premature mortality(YLL), years lived with disability(YLD) and disability-adjusted life years (DALY) of COPD in China in 1990 and 2010 for Chinese people aged 15 years and above. The death rate and DALY rate of COPD in China in 1990 and 2010 were compared. Results In 2010, 0.934 million people (0.534 million men and 0.400 million women) aged over 15 years died from COPD, decreased 34.5% (24.3% for men and 44.4% for women) compared with that in 1990 (1.425 million with 0.705 million men and 0.720 million women). There were 41.764 million COPD patients in 2010 (22.111 million men and 19.653 million women), increased 42.1%(41.7%for men and 42.6%for women) compared with 1990 (29.382 million patients with 15.599 million men and 13.783 million women). The mortality rate of COPD decreased for 61.5%from 2.352/100 000 in 1990 to 90.5/100 000 in 2010. The prevalence rate of COPD was 4.2%and 3.9%in 1990 and 2010,respectively. The DALY, YLL and YLD due to COPD was 16.598, 12.946, and 3.652 million person years,respectively in 2010. The YLD increased 42.3%compared with 1990 (2.567 million person years). From 1990 to 2010, the age-standardized DALY rate, YLL rate and YLD rate decreased from 4 120.1/100 000 to 1 575.9/100 000, from 3 756.9/100 000 to 1 235.6/100 000 and from 363.2/100 000 to 340.3/100 000,respectively. Conclusion Although there was significant decrease of DALY due to COPD in 2010, compared to 1990, the YLD burden is still increasing.