CAJ | 학술논문

目的：观察视网膜静脉阻塞( retinal vein occlusion,RVO)黄斑水肿患者雷珠单抗治疗后脉络膜厚度的变化。 　　方法：RVO黄斑水肿患者36例36眼行雷珠单抗3+prn次玻璃体腔注射治疗。随访1a,观察患眼及对侧眼治疗前和治疗后中心凹下脉络膜厚度的变化。 　　结果：治疗前、治疗后1,6,12 mo时患眼平均中心凹下脉络膜厚度( Subfoveal choroidal thickness,SFCT)分别为246.7±115.0,220.5±102.0,198.3±114.0,212.6±96.0μm,差异有统计学意义(P<0.05)。对侧眼平均SFCT分别为229.4±108.0,226.3±107.0,228.6±127.0,223.6±101.0μm,对侧眼治疗前后中心凹下脉络膜厚度的变化无差异。 　　结论：RVO黄斑水肿患者雷珠单抗治疗后中心凹下脉络膜厚度明显降低。雷珠单抗玻璃体腔注射治疗可能影响脉络膜血流状态。
목적：관찰시망막정맥조새( retinal vein occlusion,RVO)황반수종환자뢰주단항치료후맥락막후도적변화。 　　방법：RVO황반수종환자36례36안행뢰주단항3+prn차파리체강주사치료。수방1a,관찰환안급대측안치료전화치료후중심요하맥락막후도적변화。 　　결과：치료전、치료후1,6,12 mo시환안평균중심요하맥락막후도( Subfoveal choroidal thickness,SFCT)분별위246.7±115.0,220.5±102.0,198.3±114.0,212.6±96.0μm,차이유통계학의의(P<0.05)。대측안평균SFCT분별위229.4±108.0,226.3±107.0,228.6±127.0,223.6±101.0μm,대측안치료전후중심요하맥락막후도적변화무차이。 　　결론：RVO황반수종환자뢰주단항치료후중심요하맥락막후도명현강저。뢰주단항파리체강주사치료가능영향맥락막혈류상태。
AIM: To observe the changes in subfoveal choroidal thickness ( SFCT ) after intravitreal injections of ranibizumab ( IVR ) for macular edema secondary to retinal vein occlusion ( RVO) . METHODS:Thirty-six eyes of 36 patients with macular edema secondary to RVO) were treated with 0. 5mg IVR monthly for 3mo and received additional IVR as needed over the following 1a period. SFCT of the all eyes ( the affected eyes with RVO and unaffected fellow eyes ) was measured by enhanced depth imaging optical coherence tomography images before and after the IVR. RESULTS: The mean SFCT of the affected eyes with RVO decreased from 246. 7±115. 0μm at baseline to 220. 5±102.0μm at 1mo (P<0.05), 198.3± 114.0μm at 6mo (P<0.01), 212. 6± 96. 0μm at 12mo (P<0. 01). Whereas the fellow eyes changed from 229. 4±108. 0μm at baseline to 226. 3±107. 0μm at 1mo (P>0. 05), 228. 6±127. 0μm at 6mo (P>0.05), 223.6±101.0μm at 12mo(P>0.05). There were statistically significant difference between affected eyes with RVO and unaffected fellow eyes. CONCLUSION: The SFCT is decreased after IVR for macular edema secondary to RVO. IVR seems to affect the hemorheology of the choroid.