国际病毒学杂志
國際病毒學雜誌
국제병독학잡지
INTERNATIONAL JOURNAL OF VIROLOGY
2015年
2期
133-136
,共4页
李卫民%饶俊昌%雷险峰%杨江波%倪红
李衛民%饒俊昌%雷險峰%楊江波%倪紅
리위민%요준창%뢰험봉%양강파%예홍
咪喹莫特乳膏%尖锐湿疣%免疫调节%复发率%激光疗法%人乳头瘤病毒(HPV)
咪喹莫特乳膏%尖銳濕疣%免疫調節%複髮率%激光療法%人乳頭瘤病毒(HPV)
미규막특유고%첨예습우%면역조절%복발솔%격광요법%인유두류병독(HPV)
Imiquimod cream%Genital warts%Immunomodulatory function%Relapse rate%Laser therapy
目的 探讨采用咪喹莫特乳膏对尖锐湿疣免疫调节作用以及复发率的情况.方法 将尖锐湿疣患者80例随机分为观察组和对照组,各40例.对照组给予激光治疗;观察组在激光治疗后给予咪喹莫特乳膏治疗.结果 观察组治疗总有效率为92.50％,对照组患者治疗总有效率为80.0％,观察组治疗后复发率为12.50％,而对照组复发率为40.00％,差异具有统计学意义(P＜0.05).治疗后,观察组患者IL-4和IL-10水平低于对照组患者IL-4和IL-10水平,且观察组患者IL-12和IFN-γ水平高于对照组患者IL-12和IFN-γ水平,差异具有统计学意义(P＜0.01).治疗后观察组患者CD +4、CD +4/CD +8、NK水平均高于对照组患者CD +4、CD+ 4/CD+8、NK水平,差异具有统计学意义(P＜0.01).观察组患者CD+8水平低于对照组患者CD +8水平,差异具有统计学意义(P＜0.01).治疗6个月后,观察组尖锐湿疣复发患者的CD+3、CD+4、CD+ 4/CD+8以及NK水平低于未复发患者CD+3、CD+4、CD+ 4/CD+8以及NK水平;且复发患者的CD +8水平高于未复发患者CD +8水平,差异具有统计学意义(P＜0.05).结论 咪喹莫特乳膏治疗尖锐湿疣疗效显著,可有效降低复发率,提高患者细胞免疫调节作用是防止尖锐湿疣复发的重要机制.
目的 探討採用咪喹莫特乳膏對尖銳濕疣免疫調節作用以及複髮率的情況.方法 將尖銳濕疣患者80例隨機分為觀察組和對照組,各40例.對照組給予激光治療;觀察組在激光治療後給予咪喹莫特乳膏治療.結果 觀察組治療總有效率為92.50％,對照組患者治療總有效率為80.0％,觀察組治療後複髮率為12.50％,而對照組複髮率為40.00％,差異具有統計學意義(P＜0.05).治療後,觀察組患者IL-4和IL-10水平低于對照組患者IL-4和IL-10水平,且觀察組患者IL-12和IFN-γ水平高于對照組患者IL-12和IFN-γ水平,差異具有統計學意義(P＜0.01).治療後觀察組患者CD +4、CD +4/CD +8、NK水平均高于對照組患者CD +4、CD+ 4/CD+8、NK水平,差異具有統計學意義(P＜0.01).觀察組患者CD+8水平低于對照組患者CD +8水平,差異具有統計學意義(P＜0.01).治療6箇月後,觀察組尖銳濕疣複髮患者的CD+3、CD+4、CD+ 4/CD+8以及NK水平低于未複髮患者CD+3、CD+4、CD+ 4/CD+8以及NK水平;且複髮患者的CD +8水平高于未複髮患者CD +8水平,差異具有統計學意義(P＜0.05).結論 咪喹莫特乳膏治療尖銳濕疣療效顯著,可有效降低複髮率,提高患者細胞免疫調節作用是防止尖銳濕疣複髮的重要機製.
목적 탐토채용미규막특유고대첨예습우면역조절작용이급복발솔적정황.방법 장첨예습우환자80례수궤분위관찰조화대조조,각40례.대조조급여격광치료;관찰조재격광치료후급여미규막특유고치료.결과 관찰조치료총유효솔위92.50％,대조조환자치료총유효솔위80.0％,관찰조치료후복발솔위12.50％,이대조조복발솔위40.00％,차이구유통계학의의(P＜0.05).치료후,관찰조환자IL-4화IL-10수평저우대조조환자IL-4화IL-10수평,차관찰조환자IL-12화IFN-γ수평고우대조조환자IL-12화IFN-γ수평,차이구유통계학의의(P＜0.01).치료후관찰조환자CD +4、CD +4/CD +8、NK수평균고우대조조환자CD +4、CD+ 4/CD+8、NK수평,차이구유통계학의의(P＜0.01).관찰조환자CD+8수평저우대조조환자CD +8수평,차이구유통계학의의(P＜0.01).치료6개월후,관찰조첨예습우복발환자적CD+3、CD+4、CD+ 4/CD+8이급NK수평저우미복발환자CD+3、CD+4、CD+ 4/CD+8이급NK수평;차복발환자적CD +8수평고우미복발환자CD +8수평,차이구유통계학의의(P＜0.05).결론 미규막특유고치료첨예습우료효현저,가유효강저복발솔,제고환자세포면역조절작용시방지첨예습우복발적중요궤제.
Objective To investigate the immunomodulatory effects and recurrence influence of imiquimod cream for treating patients with condyloma acuminatum.Methods 80 patients with genital warts were randomly divided into the observation group and the control group,40 cases in each.Control group was given laser treatment and observation group was given imiquimod cream treatment after laser treatment.Resuits The total effective rate of the the observation group was 92.50％ and 80.0％ of the control group.The difference was statistically significant (P ＜ 0.05).After treatment,IL-4 and IL-10 levels of the observation group were lower than those of the control group.IL-12 and IFN-γ levels in the observation group were higher than those in the control group.The difference was statistically significant (P ＜ 0.01).After treatment,CD +4,CD + 4 /CD + 8,NK levels in the observation group were higher than those of in the control group.The difference was statistically significant (P ＜ 0.01).CD + 8 level in the observation group was lower than that in the control group,and the difference was statistically significant (P ＜ 0.01).After 6 months treatment,CD + 3,CD + 4,CD +4/CD + 8 and NK levels of the observation group were lower than those of the control group.CD + 8 level of relapse patients were higher than that of patients without recurrence and the difference was statistically significant (P ＜ 0.05).Conclusions The clinical effect of imiquimod in treatment of genital warts was significant,which can effectively reduce the recurrence rate and improve the patient cell immunomodulatory function,and prevent the recurrence of genital warts.
