国际病毒学杂志
國際病毒學雜誌
국제병독학잡지
INTERNATIONAL JOURNAL OF VIROLOGY
2015年
2期
111-114
,共4页
HBV DNA%乙肝病毒标志物%大三阳%血清
HBV DNA%乙肝病毒標誌物%大三暘%血清
HBV DNA%을간병독표지물%대삼양%혈청
HBV DNA%HBV markers%HBeAg%Serum
目的 分析慢性乙型肝炎患者血清HBV DNA与乙肝标志物(HBV-M)、肝功能ALT、AST的关系,以期对慢性乙肝患者的防治提供借鉴.方法 选取在2011年4月至2012年6月入住我院慢性乙肝患者100例为研究对象,搜集乙肝六项、肝功能等资料,探讨HBV DNA载量与HBV-M、ALT、AST含量的关系.结果 各阳性模式的病毒载量比较,大三阳病毒载量高于其他组,差异有统计学意义(P＜0.05),其他各组比较,差异无统计学意义(P＞0.05).阳性率比较,大三阳高于其他组,差异有统计学意义(P＜0.05),其他各组比较,差异无统计学意义(P＞0.05).血清HBV DNA载量与血清HBeAg滴度无相关性(r=0.683,P＞0.05);血清HBV DNA载量与HBsAg含量无相关性(r=-0.483,P＞0.05);血清HBV DNA载量与ALT无相关性(r=-0.157,P＞0.05),血清HBV DNA载量与AST水平也无相关性(r=0.062,P＞0.05).结论 大三阳血清HBV DNA载量、病毒阳性率均高于其他阳性模式;但血清HBV DNA定量值的高低与HBV-M、ALT、AST含量无相关性,所以,HBV DNA可反映HBV在外周血的复制情况,并不能反映肝脏损伤程度及预后.
目的 分析慢性乙型肝炎患者血清HBV DNA與乙肝標誌物(HBV-M)、肝功能ALT、AST的關繫,以期對慢性乙肝患者的防治提供藉鑒.方法 選取在2011年4月至2012年6月入住我院慢性乙肝患者100例為研究對象,搜集乙肝六項、肝功能等資料,探討HBV DNA載量與HBV-M、ALT、AST含量的關繫.結果 各暘性模式的病毒載量比較,大三暘病毒載量高于其他組,差異有統計學意義(P＜0.05),其他各組比較,差異無統計學意義(P＞0.05).暘性率比較,大三暘高于其他組,差異有統計學意義(P＜0.05),其他各組比較,差異無統計學意義(P＞0.05).血清HBV DNA載量與血清HBeAg滴度無相關性(r=0.683,P＞0.05);血清HBV DNA載量與HBsAg含量無相關性(r=-0.483,P＞0.05);血清HBV DNA載量與ALT無相關性(r=-0.157,P＞0.05),血清HBV DNA載量與AST水平也無相關性(r=0.062,P＞0.05).結論 大三暘血清HBV DNA載量、病毒暘性率均高于其他暘性模式;但血清HBV DNA定量值的高低與HBV-M、ALT、AST含量無相關性,所以,HBV DNA可反映HBV在外週血的複製情況,併不能反映肝髒損傷程度及預後.
목적 분석만성을형간염환자혈청HBV DNA여을간표지물(HBV-M)、간공능ALT、AST적관계,이기대만성을간환자적방치제공차감.방법 선취재2011년4월지2012년6월입주아원만성을간환자100례위연구대상,수집을간륙항、간공능등자료,탐토HBV DNA재량여HBV-M、ALT、AST함량적관계.결과 각양성모식적병독재량비교,대삼양병독재량고우기타조,차이유통계학의의(P＜0.05),기타각조비교,차이무통계학의의(P＞0.05).양성솔비교,대삼양고우기타조,차이유통계학의의(P＜0.05),기타각조비교,차이무통계학의의(P＞0.05).혈청HBV DNA재량여혈청HBeAg적도무상관성(r=0.683,P＞0.05);혈청HBV DNA재량여HBsAg함량무상관성(r=-0.483,P＞0.05);혈청HBV DNA재량여ALT무상관성(r=-0.157,P＞0.05),혈청HBV DNA재량여AST수평야무상관성(r=0.062,P＞0.05).결론 대삼양혈청HBV DNA재량、병독양성솔균고우기타양성모식;단혈청HBV DNA정량치적고저여HBV-M、ALT、AST함량무상관성,소이,HBV DNA가반영HBV재외주혈적복제정황,병불능반영간장손상정도급예후.
Objective To analyze the relationship between HBV DNA load and HBV-M,ALT,AST content in the serum of patients with chronic hepatitis B,and to provide reference for the prevention and treatment of patients with chronic hepatitis B.Methods 100 patients with chronic hepatitis B were selected as research subjects from April 2011 to June 2012 in our hospital.Hepatitis B six,liver function and other information were collected and the relationship between HBV DNA load and HBV-M,ALT,AST content was analyzed.Results Viral load of HBeAg group was higher than that of the other positive mode (P ＜ 0.05),and there was no statistically significant among all other groups.Viral positive rate of HBeAg group was high-er than that of the other groups (P ＜ 0.05),and there was no statistically significant among all other groups (P ＞ 0.05).There had no correlation between serum HBV DNA load and serum HBeAg titer (r =0.683,＞ 0.05).There had no correlation between HBV DNA load and HBsAg serum (r =-0.483,P ＞ 0.05).There had no correlation between serum HBV DNA load and ALT (r =-0.157,P ＞ 0.05).There had no correlation between serum AST levels,HBV DNA load,and AST (r =0.062,P ＞ 0.05).Conclusions HBV DNA load and viral positive rate of HBeAg group than that of the other positive mode,but the level of serum HBV DNA quantitative values and HBV-M,ALT,AST showed no correlation.Therefore,HBV DNA load could reflected the HBV replication situation and could not explain the degree of liver injury and prognosis.
