CAJ | 학술논문

目的探讨HAART后HIV/AIDS患者颈总动脉分叉处内中膜厚度的变化并分析相关因素.方法我们对40例初治患者和98例正在治疗的患者进行了横断面研究,根据患者的治疗时间将接受治疗的患者分为三组,通过多普勒超声检测颈总动脉分叉处内膜中层厚度、流式技术检测CD4+T细胞绝对计数,使用PCR检测血浆病毒载量,收集患者临床资料,如年龄、空腹血脂(包括总甘油三酯、总胆固醇、HDL、LDL)水平、D-二聚体检测值.使用SPSS 19.0对患者各项检查结果进行单因素方差分析.结果四组患者性别年龄没有统计学差异,治疗前CD4+T细胞绝对计数之间的差异具有统计学意义(P＜0.05),且治疗越早的患者治疗前CD4+T细胞绝对计数越低.相比于未治疗的患者,治疗后患者的CD4+T细胞绝对计数、颈总动脉分叉处内膜中层厚度、胆固醇水平及HDL水平均升高,血浆病毒载量下降,且差异有统计学意义(P＜0.05).治疗后患者之间并无统计学差异.结论 HIV/AIDS患者HAART后颈动脉内中膜厚度增厚可能与血脂异常有关,而且可能发生在HAART的早期.
목적 탐토HAART후HIV/AIDS환자경총동맥분차처내중막후도적변화병분석상관인소.방법 아문대40례초치환자화98례정재치료적환자진행료횡단면연구,근거환자적치료시간장접수치료적환자분위삼조,통과다보륵초성검측경총동맥분차처내막중층후도、류식기술검측CD4+T세포절대계수,사용PCR검측혈장병독재량,수집환자림상자료,여년령、공복혈지(포괄총감유삼지、총담고순、HDL、LDL)수평、D-이취체검측치.사용SPSS 19.0대환자각항검사결과진행단인소방차분석.결과 사조환자성별년령몰유통계학차이,치료전CD4+T세포절대계수지간적차이구유통계학의의(P＜0.05),차치료월조적환자치료전CD4+T세포절대계수월저.상비우미치료적환자,치료후환자적CD4+T세포절대계수、경총동맥분차처내막중층후도、담고순수평급HDL수평균승고,혈장병독재량하강,차차이유통계학의의(P＜0.05).치료후환자지간병무통계학차이.결론 HIV/AIDS환자HAART후경동맥내중막후도증후가능여혈지이상유관,이차가능발생재HAART적조기.
Objective To study the impact of highly active antiretroviral therapy on carotid intimamedia thickness and analyze the related factors.Methods A cross-sectional study was carried out on 40 HAART-naive patients and 98 HAART treated patients.We measured carotid intima-media thickness through doppler ultrasound measurement,HIV-1 RNA levels in plasma were measured by PCR,CD4 + T cell count were measured by FACS Calibur flow cytometry.We also collected patients' clinical data,such as age,fasting lipid level(include total triglycerides,total cholesterol,LDL and HDL),D-dimer level.Oneway ANOVA test was used to statistical analysis.Results The age and gender of the four groups were matched,the initiate CD4 +T cell between the four groups have statistical differences (P ＜0.05).The longer the time of the patients received HAART the lower their initiate CD4 + T cell count was.Cross-sectional CD4+T cell,carotid intima-media thickness,the level of fasting total cholesterol and HDL were all increased,the differences have statistical difference(P ＜ 0.05),HIV-RNA level were decreased and have statistical difference.The significant changes were happened in the first year after HAART,patients after HAART don' t have statistical differences.The level of fasting triglycerides of the four groups had no statistical differences(P ＞ 0.05).Conclusions The increase of CIMT after HAART may related to the dyslipidemia,and may occur in the early days of HAART.