CAJ | 학술논문

目的：观察齐拉西酮联合小剂量氯氮平对男性难治性精神分裂症患者认知功能的影响及临床疗效、安全性研究。方法：将100例男性难治性精神分裂症患者随机分为两组各50例，治疗组给予齐拉西酮联合小剂量氯氮平治疗，对照组给予氯氮平治疗。两组均于治疗前后采用阳性与阴性症状量表（ PANSS ）、韦氏成人智力量表（ WAIS－RC）、个人与社会功能量表（ PSP）及不良反应发生量表评定认知功能影响及临床疗效与安全性。结果：两组患者在治疗12周后PANSS总分及各因子分均明显下降，且差异具有统计学意义（t＝16．98，P＜0．05）；治疗后，治疗组WAIS－RC评分及PSP评分均显著提高，且两组差异具有统计学意义（t＝4．76，2．54；P＜0．05）；治疗12周后，两组间临床疗效相当，且治疗期间，治疗组不良反应的发生率明显低于对照组，两组差异具有统计学意义（χ2＝4．24，P＜0．05）。结论：齐拉西酮联合小剂量氯氮平治疗男性难治性精神分裂症与单用氯氮平治疗临床疗效相当，但安全性高，且能更好地改善患者的认知功能。
목적：관찰제랍서동연합소제량록담평대남성난치성정신분렬증환자인지공능적영향급림상료효、안전성연구。방법：장100례남성난치성정신분렬증환자수궤분위량조각50례，치료조급여제랍서동연합소제량록담평치료，대조조급여록담평치료。량조균우치료전후채용양성여음성증상량표（ PANSS ）、위씨성인지역량표（ WAIS－RC）、개인여사회공능량표（ PSP）급불량반응발생량표평정인지공능영향급림상료효여안전성。결과：량조환자재치료12주후PANSS총분급각인자분균명현하강，차차이구유통계학의의（t＝16．98，P＜0．05）；치료후，치료조WAIS－RC평분급PSP평분균현저제고，차량조차이구유통계학의의（t＝4．76，2．54；P＜0．05）；치료12주후，량조간림상료효상당，차치료기간，치료조불량반응적발생솔명현저우대조조，량조차이구유통계학의의（χ2＝4．24，P＜0．05）。결론：제랍서동연합소제량록담평치료남성난치성정신분렬증여단용록담평치료림상료효상당，단안전성고，차능경호지개선환자적인지공능。
Objective:To compare the influence of ziprasidone combined with small -dose of clozap-ine on cognitive function ,efficacy safety in male patients with refractory schizophrenia .Methods:A total of 100 male patients with refractory schizophrenia were randomly divided into two groups with each group of 50 cases.Treatment group received ziprasidone and small -dose of clozapine while control group re-ceived clozapine only .Before and after treatment ,clinical efficacy and symptoms were evaluated by posi-tive and negative symptoms rating scale ( PANSS) and cognitive function were assessed by Wechsler A-dult Memory Scale ( WAIS-RC) and personal and social performance scale ( PSP) while adverse reac-tions were assessed by side effects scale .Results:Compared with control group , patients in treatment group the PANSS total scores and positive symptoms ,negative symptoms ,psychopathology scores were de-creased significantly after treatment 12 weeks ,there were statistically significant ( t=16 .98 ,P<0 .05 );After treatment ,there were significant improvements in WAIS -RC and PSP scores between two groups (t=4.76,2.54;P<0.05);After 12 weeks,the total effectiveness between 2 groups were not significant-ly different,and during treatment ,the group of treatment was significantly lower than the group of control in scores of occurrence of adverse reactions (χ2 =4.24,P<0.05).Conclusion:Ziprasidone combined with small-dose of clozapine has the same effect as clozapine in clinical effect in patients with refractory schizophrenia ,but more safe ,and it improves cognitive function more better .