CAJ | 학술논문

目的：观察重复经颅磁刺激（ rTMS）和利培酮对阿尔茨海默病患者精神行为症状（ BPSD ）的临床疗效。方法：将45例患有阿尔茨海默病且伴有BPSD的患者随机分为研究组（20例）和对照组（25例），研究组患者接受20次5HZ rTMS，对照组接受利培酮治疗，两组治疗期间维持原有的胆碱酯酶抑制剂。治疗前及治疗2周和6周后进行神经精神科问卷（ Neuropsychiatric Inventory ，NPI）和简明精神状态检查（ MMSE）等评分观察疗效。结果：45例患者完成治疗，治疗6周后两组NPI得分均有降低，组内治疗前后比较，差异达统计学意义（ t＝12．18，2．29；P＜0．05）；两组间评分比较无显著性差异（t＝0．68，0．42，0．66；P＞0．05）；两组的MMSE评分有所上升，治疗6周后两组内前后比较，差异有统计学意义（t＝2．45，2．92；P＜0．05）两组间评分无显著性差异（t＝0．17，0．92，0．26；P＞0．05）。结论：重复经颅磁刺激可能是控制轻中度阿尔茨海默病患者BPSD的一种有效而安全的治疗方法。
목적：관찰중복경로자자격（ rTMS）화리배동대아이자해묵병환자정신행위증상（ BPSD ）적림상료효。방법：장45례환유아이자해묵병차반유BPSD적환자수궤분위연구조（20례）화대조조（25례），연구조환자접수20차5HZ rTMS，대조조접수리배동치료，량조치료기간유지원유적담감지매억제제。치료전급치료2주화6주후진행신경정신과문권（ Neuropsychiatric Inventory ，NPI）화간명정신상태검사（ MMSE）등평분관찰료효。결과：45례환자완성치료，치료6주후량조NPI득분균유강저，조내치료전후비교，차이체통계학의의（ t＝12．18，2．29；P＜0．05）；량조간평분비교무현저성차이（t＝0．68，0．42，0．66；P＞0．05）；량조적MMSE평분유소상승，치료6주후량조내전후비교，차이유통계학의의（t＝2．45，2．92；P＜0．05）량조간평분무현저성차이（t＝0．17，0．92，0．26；P＞0．05）。결론：중복경로자자격가능시공제경중도아이자해묵병환자BPSD적일충유효이안전적치료방법。
Objecti ve:To explore the effects of repetitive Transcranial Magnetic Stimulation ( rTMS ) in treatment of behavioral and psychological symptoms of dementia ( BPSD) of patients with mild-to-moderate Alzheimer's disease ( AD ) .Methods:45 mild -to moderate AD patients accompanied with BPSD were randomly divided to active rTMS group (20 cases) and Risperidone group (25 cases).Sub-jects of rTMS group were treated with rTMS respectively for 20 times during 6 weeks,and the subjects of Risperidone group were treated with risperidone ,all patients were received with stable cholinesterase in-hibitors.Neuropsychiatric Inventory ( NPI)and Mini -Mental Status Examination ( MMSE) were as-sessed before treatment and 2 weeks and 6 weeks after treatment .Results:45 subjects completed the trial . The NPI improved significantly after 6 weeks of active treatment .There was no statistical significance in TESS between two groups .Conc lusion:In this study ,rTMS seems a promising effective and safe therapies for BPSD of mild-to-moderate AD.