CAJ | 학술논문

目的探讨尼麦角林联合高压氧治疗血管性认知功能障碍(VCI)的疗效.方法选取血管性认知功能障碍患者120例,随机分为尼麦角林治疗组40例,高压氧治疗组40例,联合治疗组40例,疗程共8周,以简易精神状态检查表(MMSE)、韦克斯勒记忆量表(WMS)和日常生活能力量表(ADL)为评价指标,评价3组患者的疗效.结果 3组患者临床资料比较差异无统计学意义(均P＞0.05),具有可比性.经8周治疗干预后,联合治疗组MMSE、WMS、ADL较治疗前均有改善(P＜0.01).尼麦角林治疗组上述三项指标改善明显(P＜0.05),而高压氧治疗组MMSE、ADL评分较前改善(P＜0.05),联合治疗组与尼麦角林治疗组和高压氧治疗组组间比较,上述指标差异有统计学意义(P＜0.05).而尼麦角林组与高压氧治疗组比较,仅MMSE差异有统计学意义.3组均无明显相关不良反应出现.结论在血管性认知功能障碍治疗中,尼麦角林联合高压氧治疗疗效显著,患者日常生活能力和认知能力提高明显,无不良反应发生,值得在临床中推广.
목적 탐토니맥각림연합고압양치료혈관성인지공능장애(VCI)적료효.방법 선취혈관성인지공능장애환자120례,수궤분위니맥각림치료조40례,고압양치료조40례,연합치료조40례,료정공8주,이간역정신상태검사표(MMSE)、위극사륵기억량표(WMS)화일상생활능역량표(ADL)위평개지표,평개3조환자적료효.결과 3조환자림상자료비교차이무통계학의의(균P＞0.05),구유가비성.경8주치료간예후,연합치료조MMSE、WMS、ADL교치료전균유개선(P＜0.01).니맥각림치료조상술삼항지표개선명현(P＜0.05),이고압양치료조MMSE、ADL평분교전개선(P＜0.05),연합치료조여니맥각림치료조화고압양치료조조간비교,상술지표차이유통계학의의(P＜0.05).이니맥각림조여고압양치료조비교,부MMSE차이유통계학의의.3조균무명현상관불량반응출현.결론 재혈관성인지공능장애치료중,니맥각림연합고압양치료료효현저,환자일상생활능력화인지능력제고명현,무불량반응발생,치득재림상중추엄.
Objective To investigate the efficacy of nicergoline combined with hyperbaric oxygen treatment on vascular cognitive impairment.Methods 120 patients with vascular cognitive impairment were randomly divided into 3 treatment groups:nicergoline,hyperbaric oxygen,and both treatment (n=40,each) for 8 weeks.Mini mental state examination (MMSE),Wechsler memory scale (WMS) and activities of daily living scale (ADL) were used as assessing items.The efficacy of treatment in each group was evaluated.Results There were no significant differences in clinical data among the three groups(x2=0.324,t=0.265 and 0.861,P=0.764,0.784 and 0.386).After 8 weeks of intervention,scores of MMSE,WMS and ADL were significantly improved in the combined treatment groups compared with pre-treatment (all P＜0.01),and the improvements were observed in nicergoline group (all P＜0.05),while only MMSE and ADL were improved in hyperbaric oxygen group (both P＜0.05).There were significant differences in scores of MMSE,WMS and ADL between combination therapy group and nicergoline group,hyperbaric oxygen group after treatment (all P＜0.05).But only MMSE had significant difference between niccrgoline group and hyperbaric oxygen group after treatment.No significant side effects were observed in the three groups.Conclusions Combination treatment of nicergline and hyperbaric oxygen has better efficacy on vascular cognitive impairment.It can markedly improve the activities of daily living and cognitive function without significant side effects,which is worthy of application in clinical medicine.