CAJ | 학술논문

目的分析老年多发性骨髓瘤初治患者放弃化疗状况及其相关因素,为临床提高患者的化疗依从性提供依据.方法回顾性分析2000-2010年在我院血液科住院、符合临床诊断标准的老年初治多发性骨髓瘤患者156例,随机抽取同期住院的中青年多发性骨髓瘤患者123例作为对照组,统计放弃化疔原因,并进行相关因素分析.结果老年组初治患者放弃化疗率为58.3％(91/156),对照组为35.0％(43/123),两组比较差异有统计学意义(P＜0.05).放弃治疗的91例老年患者中,51.7％确诊后未接受化疗.老年患者放弃化疗的主要原因依次为病情危重、经济困难和耐受性差;而对照组主要原因为经济困难.结论老年多发性骨髓瘤初治患者放弃化疗的比率较高,高龄、病情危重、经济困难、耐受力差是放弃化疗的独立危险因素.
목적 분석노년다발성골수류초치환자방기화료상황급기상관인소,위림상제고환자적화료의종성제공의거.방법 회고성분석2000-2010년재아원혈액과주원、부합림상진단표준적노년초치다발성골수류환자156례,수궤추취동기주원적중청년다발성골수류환자123례작위대조조,통계방기화정원인,병진행상관인소분석.결과 노년조초치환자방기화료솔위58.3％(91/156),대조조위35.0％(43/123),량조비교차이유통계학의의(P＜0.05).방기치료적91례노년환자중,51.7％학진후미접수화료.노년환자방기화료적주요원인의차위병정위중、경제곤난화내수성차;이대조조주요원인위경제곤난.결론 노년다발성골수류초치환자방기화료적비솔교고,고령、병정위중、경제곤난、내수력차시방기화료적독립위험인소.
Objective To study influencing factors for giving up chemotherapy during initial treatment in elderly patients with multiple myeloma.Methods A total of 156 elderly patients diagnosed as multiple myeloma from 2000-2010 were retrospectively analyzed.And 123 young patients with multiple myeloma were selected as control group.The causes for giving up the chemotherapy and its related factors were recorded and analyzed.Results The rate of giving up the initial chemotherapy was higher in the elderly than in young patients [58.3％ (91/156) vs.35.0％ (43/123),P＜0.05].51.7％ of the elderly patients did not accept chemotherapy after diagnosis.The main factors for giving up the initial chemotherapy in elderly patients were critically ill,economic difficult and the low tolerance.However,the economic difficulty was the first cause in the young group.Conclusions The rate of giving up the chemotherapy in the elderly patients is high.Old age,severe conditions,economic difficulty,and low tolerance are the independent factors.