中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2015年
4期
405-407
,共3页
季红莉%王清%付万发%张翼%陈明
季紅莉%王清%付萬髮%張翼%陳明
계홍리%왕청%부만발%장익%진명
螺杆菌,幽门%胃黏膜
螺桿菌,幽門%胃黏膜
라간균,유문%위점막
Helicobacter,pylori%Gastric mucosa
目的 探讨幽门螺杆菌(Hp)感染与老年患者胃黏膜组织病理改变特点,以提高临床医师对Hp感染后的胃黏膜组织病理变化特点的认识.方法 回顾性分析2014年1-6月于我院接受胃镜及碳13呼气试验检查的良性上消化道疾病患者278例,依据年龄分为年龄≥60岁老年组111例和年龄＜ 60岁非老年组167例,分别观察两组患者Hp感染情况及胃黏膜组织病理变化(慢性重度炎症、中性粒细胞浸润、淋巴滤泡、腺体萎缩、肠上皮化生)与Hp感染的关系.结果 老年组与非老年组比较,Hp感染率为分别为27.0％(30/111)和36.5％(61/167),差异无统计学意义;腺体萎缩分别13.5％(15/111)和6.0％(10/167),差异有统计学意义(P=0.028);Hp感染者重度慢性炎症、中性粒细胞浸润、淋巴滤泡形成、腺体萎缩和肠上皮化生分别为73.6％、70.3％、14.3％、18.7％、29.7％,均高于Hp阴性者19.8％、3.2％、0.5％、4.3％、8.6％,差异均有统计学学意义(P=0.000);排除Hp感染因素,老年组与非老年组腺体萎缩率分别为8.6％和0).9％(P=0.013);Hp阳性肠上皮化生率老年组与非老年组分别为43.3％和23.0％(P=0.045).结论 Hp感染与胃黏膜组织重度慢性炎症、中性粒细胞浸润、淋巴滤泡形成有关;腺体萎缩、肠上皮化生不仅与Hp感染有关,年龄亦是其影响因素.
目的 探討幽門螺桿菌(Hp)感染與老年患者胃黏膜組織病理改變特點,以提高臨床醫師對Hp感染後的胃黏膜組織病理變化特點的認識.方法 迴顧性分析2014年1-6月于我院接受胃鏡及碳13呼氣試驗檢查的良性上消化道疾病患者278例,依據年齡分為年齡≥60歲老年組111例和年齡＜ 60歲非老年組167例,分彆觀察兩組患者Hp感染情況及胃黏膜組織病理變化(慢性重度炎癥、中性粒細胞浸潤、淋巴濾泡、腺體萎縮、腸上皮化生)與Hp感染的關繫.結果 老年組與非老年組比較,Hp感染率為分彆為27.0％(30/111)和36.5％(61/167),差異無統計學意義;腺體萎縮分彆13.5％(15/111)和6.0％(10/167),差異有統計學意義(P=0.028);Hp感染者重度慢性炎癥、中性粒細胞浸潤、淋巴濾泡形成、腺體萎縮和腸上皮化生分彆為73.6％、70.3％、14.3％、18.7％、29.7％,均高于Hp陰性者19.8％、3.2％、0.5％、4.3％、8.6％,差異均有統計學學意義(P=0.000);排除Hp感染因素,老年組與非老年組腺體萎縮率分彆為8.6％和0).9％(P=0.013);Hp暘性腸上皮化生率老年組與非老年組分彆為43.3％和23.0％(P=0.045).結論 Hp感染與胃黏膜組織重度慢性炎癥、中性粒細胞浸潤、淋巴濾泡形成有關;腺體萎縮、腸上皮化生不僅與Hp感染有關,年齡亦是其影響因素.
목적 탐토유문라간균(Hp)감염여노년환자위점막조직병리개변특점,이제고림상의사대Hp감염후적위점막조직병리변화특점적인식.방법 회고성분석2014년1-6월우아원접수위경급탄13호기시험검사적량성상소화도질병환자278례,의거년령분위년령≥60세노년조111례화년령＜ 60세비노년조167례,분별관찰량조환자Hp감염정황급위점막조직병리변화(만성중도염증、중성립세포침윤、림파려포、선체위축、장상피화생)여Hp감염적관계.결과 노년조여비노년조비교,Hp감염솔위분별위27.0％(30/111)화36.5％(61/167),차이무통계학의의;선체위축분별13.5％(15/111)화6.0％(10/167),차이유통계학의의(P=0.028);Hp감염자중도만성염증、중성립세포침윤、림파려포형성、선체위축화장상피화생분별위73.6％、70.3％、14.3％、18.7％、29.7％,균고우Hp음성자19.8％、3.2％、0.5％、4.3％、8.6％,차이균유통계학학의의(P=0.000);배제Hp감염인소,노년조여비노년조선체위축솔분별위8.6％화0).9％(P=0.013);Hp양성장상피화생솔노년조여비노년조분별위43.3％화23.0％(P=0.045).결론 Hp감염여위점막조직중도만성염증、중성립세포침윤、림파려포형성유관;선체위축、장상피화생불부여Hp감염유관,년령역시기영향인소.
Objective To investigate the correlation between helicobacter pylori infection and pathological characteristics of gastric mucosal in the elderly.Methods Retrospective analysis was conducted in 278 patients with benign upper gastrointestinal disease from January 2014 to June 2014.The patients were examined by endoscopy and 13C-UBT,and divided into elderly group (aged 60 years and over,n=111) and non-elderly group (aged＜60 years,n=167).The relationships between Hp infection and pathological changes in gastric mucosal tissue (severe chronic inflammation,neutrophil infiltration,lymph follicles,gastric gland atrophy,intestinal metaplasia) were analyzed.Results There was no significant difference in helicobacter pylori infection rate between the elderly group and non-elderly group [27.0％ (30/111) vs.36.5％ (61/167),P＞0.05].The rate of gastric gland atrophy was higher in elderly group than in non-elderly group [13.5％ (15/111) vs.6.0％ (10/167),P=0.028].The rates of severe chronic inflammation,neutrophil infiltration,lymph follicles,gland atrophy and intestinal metaplasia were 73.6％,70.3％,14.3％,18.7％,29.7％ in patients with helicobacter pylori infection,which were higher than those in patients without helicobacter pylori infection (19.8％,3.2％,0.5％,4.3％,8.6％,respectively,all P=0.000).Removing the factor of Hp infection,the rates of glands atrophy and intestinal metaplasia were higher in elderly group than in non-elderly group (8.6％ vs.0.9％,43.3％ vs.23.0％,P=0.013 and 0.045).Conclusions Helicobacter pylori infection correlates with severe chronic gastric mucosal inflammation,neutrophil infiltration,lymph follicles formation.Gland atrophy and intestinal metaplasia are related to the Hp infection,and age is also their influencing factor.
