CAJ | 학술논문

目的探讨术前预防性肠外营养支持对进展期胃癌患者预后的影响.方法选择医院收治的159例进展期胃癌患者为研究对象,随机分为实验组和对照组.实验组:80例,给予术前预防性肠外营养支持治疗;对照组:79例,给予传统营养支持治疗;对比分析两组术前、术后肝功能部分指标变化情况,以及术后并发症发生率和病死率.结果术后第8天,实验组谷草转氨酶、谷丙转氨酶、总胆红素和直接胆红素水平比对照组低(t分别=6.542、6.460、5.634、5.275,均P＜0.001).术后第2天和第8天,实验组患者血清白蛋白和前白蛋白指标水平比对照组高(t=12.580、12.471、6.757、12.821,均P＜0.001).实验组并发症发生率和病死率均低于对照组(x2=23.409、4.818,P＜0.001或0.05).结论进展期胃癌患者给予术前预防性肠外营养支持能够加快患者术后肝功能恢复速度,降低术后并发症发生率和病死率.
목적 탐토술전예방성장외영양지지대진전기위암환자예후적영향.방법 선택의원수치적159례진전기위암환자위연구대상,수궤분위실험조화대조조.실험조:80례,급여술전예방성장외영양지지치료;대조조:79례,급여전통영양지지치료;대비분석량조술전、술후간공능부분지표변화정황,이급술후병발증발생솔화병사솔.결과 술후제8천,실험조곡초전안매、곡병전안매、총담홍소화직접담홍소수평비대조조저(t분별=6.542、6.460、5.634、5.275,균P＜0.001).술후제2천화제8천,실험조환자혈청백단백화전백단백지표수평비대조조고(t=12.580、12.471、6.757、12.821,균P＜0.001).실험조병발증발생솔화병사솔균저우대조조(x2=23.409、4.818,P＜0.001혹0.05).결론 진전기위암환자급여술전예방성장외영양지지능구가쾌환자술후간공능회복속도,강저술후병발증발생솔화병사솔.
Objective To investigate the effect of preoperative prophylactic parenteral nutrition on prognosis of advanced gastric cancer.Methods A total of 159 patients with advanced gastric cancer in our hospital were collected,and randomly divided into experimental group and control group.80 cases in experimental group were treated with prophylactic parenteral nutrition,and 79 cases in control group were treated with traditional nutrition.The partial indexes of liver function,complications and mortality rate were compared between the two groups before and after surgery.Results The levels of aspartate aminotransferase (AST),alanine aminotransferase (ALT),total bilirubin (TBIL) and direct bilirubin (DBIL) were much lower in experimental group than in control group at 8 days after surgery (t=6.542,6.460,5.634,5.275,all P＜0.001).The levels of ALB and PAB were much higher in experimental group than in control group at 2 and 8 days after surgery (t=12.580,12.471,6.757,12.821,all P＜0.001).The incidence of complications and mortality rate were much lower in experimental group than in control group (x2 =23.409,4.818,P＜0.001 or 0.05).Conclusions Preoperative prophylactic parenteral nutrition can speed up the recovery of liver function and reduce the complications and mortality rate after surgery in patients with advanced gastric cancer.