CAJ | 학술논문

研究亲环素 A（CyPA）在正常人群及急性肾损伤（AKI）患者外周血中的浓度变化，探讨CyPA 是否与急性肾损伤有关及其可能的作用机制．检测急性肾损伤患者外周血中厄贝沙坦治疗前后 CyPA、AngII、TNFα、IL －6、IL －1α、MCP －1水平，并以正常人为对照组．结果发现 AKI 组外周血 CyPA 水平治疗前高于正常对照组．AKI 组 CyPA 与 AngII 及 TNFα、IL －6、IL －1α正相关，与 MCP －1负相关，相关系数分别为0.6，0.539，0.688，0.693，－0.725．说明 CyPA 作为一种炎症细胞介质，可能协同 AngII，参与了 AKI 患者炎性反应，加重肾小管上皮细胞损伤及细胞凋亡．通过选择性地抑制或阻断 CyPA 或 AngII 受体可能为我们提供一条对急性肾损伤的新治疗途径．
연구친배소 A（CyPA）재정상인군급급성신손상（AKI）환자외주혈중적농도변화，탐토CyPA 시부여급성신손상유관급기가능적작용궤제．검측급성신손상환자외주혈중액패사탄치료전후 CyPA、AngII、TNFα、IL －6、IL －1α、MCP －1수평，병이정상인위대조조．결과발현 AKI 조외주혈 CyPA 수평치료전고우정상대조조．AKI 조 CyPA 여 AngII 급 TNFα、IL －6、IL －1α정상관，여 MCP －1부상관，상관계수분별위0.6，0.539，0.688，0.693，－0.725．설명 CyPA 작위일충염증세포개질，가능협동 AngII，삼여료 AKI 환자염성반응，가중신소관상피세포손상급세포조망．통과선택성지억제혹조단 CyPA 혹 AngII 수체가능위아문제공일조대급성신손상적신치료도경．
CyPA concentration levels in the peripheral blood in the normal subjects and patients with acute kid-ney injury (AKI)are detected to determine whether CyPA is associated with acute kidney injury and its possible mechanism.The level of CyPA,AngII,TNFα,IL -6,IL -1 and MCP -1 are measured in patients with AKI before and after treatment with irbesatan for 4 weeks.The positive control group is composed of normal subjects.It is observed that the level of CyPA in peripheral blood of AKI group is higher than that in the normal control group,The correlation coefficient of CyPA and AngII,IL -6,IL -1,TNF and MCP -1 are 0.6,0.539,0.688, 0.693,-0.725 respectively .The results show that CyPA may act as an inflammatory cell medium which coop-erates with AngII ,promotes AKI patients with inflammatory reaction,and increases renal tubular and interstitial injury.CyPA may be a new marker of inflammation in AKI damage.Through selective inhibition of CyPA or blocking of AngII receptors may provide a new treatment of AKI.