CAJ | 학술논문

干眼症为一种多因素造成泪膜稳定性和眼表功能损害的疾病，易引起眼部不适、视力障碍、泪膜不稳定与眼表的潜在危害，可伴有泪液渗透压升高及眼表炎症反应。炎症是干眼发病中最关键因素，多种免疫细胞和炎症因子参与了干眼症的发生与发展过程。细胞凋亡、神经调节异常、性激素失调等也共同参与了干眼的发病过程。最近尽管在阐述干眼的病理生理和发病机制取得了一定进展，但目前还未形成统一标准。本文将对炎症造成干眼症眼表和泪液功能损害的可能机制进行综述。
간안증위일충다인소조성루막은정성화안표공능손해적질병，역인기안부불괄、시력장애、루막불은정여안표적잠재위해，가반유루액삼투압승고급안표염증반응。염증시간안발병중최관건인소，다충면역세포화염증인자삼여료간안증적발생여발전과정。세포조망、신경조절이상、성격소실조등야공동삼여료간안적발병과정。최근진관재천술간안적병리생리화발병궤제취득료일정진전，단목전환미형성통일표준。본문장대염증조성간안증안표화루액공능손해적가능궤제진행종술。
?Dry eye is a multi-factorial disease of tear film and ocular surface, and it can result in discomfort, visual disturbance and tear film instability and potential damage of ocular surface, accompanied by hyper osmolarity of tears and ocular surface inflammation. lnflammation is the key factor to dry eye. Many kinds of immune cells and inflammatory factors are involved in the occurrence and development of dry eye syndrome. Cell apoptosis, nerve dysregulation, disorders of sex hormones also play an important role in pathologic process of dry eye. Recently, while illustrating the pathophysiology and pathogenesis of dry eye has been made some progress, there is still no single standard. The possible mechanisms of ocular surface inflammation and tear dysfunction of dry eye were reviewed in this article.