国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2015年
5期
856-858
,共3页
杜芬%罗俊%龙琦%肖志刚%陶利娟
杜芬%囉俊%龍琦%肖誌剛%陶利娟
두분%라준%룡기%초지강%도리연
异常瞬目症%血铅%浓度
異常瞬目癥%血鉛%濃度
이상순목증%혈연%농도
abnormal eye blinking%blood lead%level
目的：了解异常瞬目症儿童其血铅水平是否存在异常。<br> 方法：以“频繁眨眼”为主诉,诊断为异常瞬目征患儿为试验组。常规行视力、屈光学、裂隙灯、角膜荧光素染色、泪膜破裂时间检查,完善血铅及微量元素检查；对照组为同时期内在我院儿童保健科以“健康查体”为主诉的患儿,且除外血铅浓度结果、其他体查结果均为正常的儿童。并按性别分为男童组及女童组。比较试验组与对照组血铅浓度的变化。<br> 结果：试验组共371例,男295例,女76例,平均年龄为男6.56±2.41岁,女6.08±2.82岁。对照组共300例,男186例,女114例,平均年龄为男6.99±3.01岁,女6.56±2.80岁。试验组中男童平均血铅浓度为63.82±24.56μg/L,正常组中男童平均血铅浓度为53.98±15.42μg/L。试验组与正常组男童的血铅浓度比较,血铅浓度偏高,差异具有显著性统计学意义(χ2=16.96,P<0.01)。试验组中女童平均血铅浓度为56.96±16.69μg/L,正常组中女童平均血铅浓度为48.18±12.35μg/L。试验组与正常组女童的血铅浓度比较,差异不具有统计学意义(χ2=5.77,P=0.56)。正常组<3岁组平均血铅浓度为48.73±11.67μg/L,3~6岁组平均血铅浓度为51.39±14.87μg/L,>6岁组平均血铅浓度为52.98±14.45μg/L。试验组儿童3岁以下组平均血铅浓度为56.57±17.89μg/L,3~6岁组平均血铅浓度为59.92±18.46μg/L,6岁以上组平均血铅浓度为67.00±32.55μg/L。其中0~3岁儿童试验组与对照组血铅浓度无统计学差异(χ2=3.54,P=0.17)。3~6岁年龄组及>6岁年龄组试验与对照组血铅浓度差异具有统计学意义(χ2=9.62,P=0.008；χ2=19.22,P=0.000)。将血铅浓度按<50,≥50μg/L且≤100μg/L,>100μg/L分为3个梯度,患儿出现异常瞬目发病率的相对危险度 RR 分为0.65,1.22,10.11。<br> 结论：异常瞬目症患儿血铅浓度偏高,异常瞬目症发病率与血铅浓度成正相关。
目的：瞭解異常瞬目癥兒童其血鉛水平是否存在異常。<br> 方法：以“頻繁眨眼”為主訴,診斷為異常瞬目徵患兒為試驗組。常規行視力、屈光學、裂隙燈、角膜熒光素染色、淚膜破裂時間檢查,完善血鉛及微量元素檢查；對照組為同時期內在我院兒童保健科以“健康查體”為主訴的患兒,且除外血鉛濃度結果、其他體查結果均為正常的兒童。併按性彆分為男童組及女童組。比較試驗組與對照組血鉛濃度的變化。<br> 結果：試驗組共371例,男295例,女76例,平均年齡為男6.56±2.41歲,女6.08±2.82歲。對照組共300例,男186例,女114例,平均年齡為男6.99±3.01歲,女6.56±2.80歲。試驗組中男童平均血鉛濃度為63.82±24.56μg/L,正常組中男童平均血鉛濃度為53.98±15.42μg/L。試驗組與正常組男童的血鉛濃度比較,血鉛濃度偏高,差異具有顯著性統計學意義(χ2=16.96,P<0.01)。試驗組中女童平均血鉛濃度為56.96±16.69μg/L,正常組中女童平均血鉛濃度為48.18±12.35μg/L。試驗組與正常組女童的血鉛濃度比較,差異不具有統計學意義(χ2=5.77,P=0.56)。正常組<3歲組平均血鉛濃度為48.73±11.67μg/L,3~6歲組平均血鉛濃度為51.39±14.87μg/L,>6歲組平均血鉛濃度為52.98±14.45μg/L。試驗組兒童3歲以下組平均血鉛濃度為56.57±17.89μg/L,3~6歲組平均血鉛濃度為59.92±18.46μg/L,6歲以上組平均血鉛濃度為67.00±32.55μg/L。其中0~3歲兒童試驗組與對照組血鉛濃度無統計學差異(χ2=3.54,P=0.17)。3~6歲年齡組及>6歲年齡組試驗與對照組血鉛濃度差異具有統計學意義(χ2=9.62,P=0.008；χ2=19.22,P=0.000)。將血鉛濃度按<50,≥50μg/L且≤100μg/L,>100μg/L分為3箇梯度,患兒齣現異常瞬目髮病率的相對危險度 RR 分為0.65,1.22,10.11。<br> 結論：異常瞬目癥患兒血鉛濃度偏高,異常瞬目癥髮病率與血鉛濃度成正相關。
목적：료해이상순목증인동기혈연수평시부존재이상。<br> 방법：이“빈번잡안”위주소,진단위이상순목정환인위시험조。상규행시력、굴광학、렬극등、각막형광소염색、루막파렬시간검사,완선혈연급미량원소검사；대조조위동시기내재아원인동보건과이“건강사체”위주소적환인,차제외혈연농도결과、기타체사결과균위정상적인동。병안성별분위남동조급녀동조。비교시험조여대조조혈연농도적변화。<br> 결과：시험조공371례,남295례,녀76례,평균년령위남6.56±2.41세,녀6.08±2.82세。대조조공300례,남186례,녀114례,평균년령위남6.99±3.01세,녀6.56±2.80세。시험조중남동평균혈연농도위63.82±24.56μg/L,정상조중남동평균혈연농도위53.98±15.42μg/L。시험조여정상조남동적혈연농도비교,혈연농도편고,차이구유현저성통계학의의(χ2=16.96,P<0.01)。시험조중녀동평균혈연농도위56.96±16.69μg/L,정상조중녀동평균혈연농도위48.18±12.35μg/L。시험조여정상조녀동적혈연농도비교,차이불구유통계학의의(χ2=5.77,P=0.56)。정상조<3세조평균혈연농도위48.73±11.67μg/L,3~6세조평균혈연농도위51.39±14.87μg/L,>6세조평균혈연농도위52.98±14.45μg/L。시험조인동3세이하조평균혈연농도위56.57±17.89μg/L,3~6세조평균혈연농도위59.92±18.46μg/L,6세이상조평균혈연농도위67.00±32.55μg/L。기중0~3세인동시험조여대조조혈연농도무통계학차이(χ2=3.54,P=0.17)。3~6세년령조급>6세년령조시험여대조조혈연농도차이구유통계학의의(χ2=9.62,P=0.008；χ2=19.22,P=0.000)。장혈연농도안<50,≥50μg/L차≤100μg/L,>100μg/L분위3개제도,환인출현이상순목발병솔적상대위험도 RR 분위0.65,1.22,10.11。<br> 결론：이상순목증환인혈연농도편고,이상순목증발병솔여혈연농도성정상관。
?AlM:To study the relationship between blood lead level and abnormal eye blinking in children. <br> ? METHODS: The patients with chief complaint of frequent eye blinking, whose diagnosis of abnormal eye blinking, were randomized to experimental group. The patients in this group carried out vision and the slit-lamp examination, detected corneal fluorescein staining and tear break-up time, and improved the level of blood lead and trace elements examination. The patients in control group with chief complaint of health physical examination in our hospital, excepted of blood lead level, the other body check results were normal and were divided into boys group and girls group according to the gender. The changes of the experimental group and control group in blood lead level were compared. <br> ?RESULTS: Totally 371 cases ( male:295 cases; female:76 cases) with mean age was 6. 56±2. 41 years and 6. 08±2. 82 years respectively were in experimental groupe. ln control group, there were 300 cases ( male: 186 cases;female:114 cases) with mean age was 6. 99±3. 01 years and 6. 56±2. 80 years respectively. The average of blood lead level of boys in experimental group was 63. 82 ±24. 56μg/L and 53. 98±15. 42μg/L in control group. The average of blood lead level in experimental group was higher than that in control group. The difference between of the two group was statistically significant (χ2=16. 96, P<0. 01 ). The average of blood lead level of girls in experimental group was 56. 96±16. 69μg/L and 48. 18±12. 35μg/L in control group. There was no difference between of the two group (χ2=5. 77, P=0. 56). ln control group, the average of blood lead level with <3 years, 3~6 years and >6 years children were 48. 73±11. 67μg/L, 51. 39 ± 14. 87μg/L, 52. 98 ± 14. 45μg/L respectively. ln expirement group, the results were 56. 57±17. 89μg/L, 59. 92±18. 46μg/L and 67. 00±32. 55μg/L in <3, 3~6 and >6 children, respectively. There was no significant difference with <3 years (χ2=3. 54, P=0. 17). The difference with 3~6 years and >6 years children were statistically significant (χ2 = 9. 62, P = 0. 008 ) and (χ2 = 19. 22, P = 0. 000 ) respectively. The blood lead level were divided into three grades: <50μg/L, 50 ~100μg/L, >100μg/L, and relative risk (RR) were 0. 65, 1. 22, and 10. 11 respectively. <br> ?CONCLUSlON: Blood lead level of experimental group is higher than that of control group. The relationship between blood lead level and abnormal eye blinking in children is positive correlation.
