国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2015年
5期
828-831
,共4页
生命早期%儿童期%危险因素%年龄相关性白内障
生命早期%兒童期%危險因素%年齡相關性白內障
생명조기%인동기%위험인소%년령상관성백내장
early-life%childhood%risk factors%age-related cataract
目的：评价生命早期及儿童期影响因素与成人年龄相关性白内障( age-related cataract,ARC)发病的关系,为早期预防、早期发现、早期治疗ARC提供理论依据。<br> 方法：我院2011-04/2012-10开展以医院为基础的病例对照研究,病例由41~60岁的360例360眼施行白内障摘除术的患者所组成。对照组由与病例的年龄和性别进行匹配、因罹患各种与ARC无关的疾病、同期入住相同医院的360例非白内障的患者所组成。采用自制的调查问卷对所有研究对象进行调查,包括研究对象的一般状况、生命早期影响因素,以及儿童期暴露因素。采用非条件Logistic回归模型对结果进行分析。<br> 结果：出生时胎龄越早,出生时体质量越低,均与发生ARC的危险性具有显著性关联(分别为 OR =1.152,95%CI：1.029~2.235, P=0.024；OR=1.374,95%CI：1.156~2.581,P=0.037)；母亲孕前糖尿病( OR=1.587,95%CI：1.177~2.915,P =0.019)、孕期糖尿病(OR =1.763,95%CI：1.375~2.367,P =0.004)、先兆子痫( OR=1.581,95%CI：1.139~1.996,P=0.021),以及妊娠期高血压(OR=1.517,95%CI：1.032~1.963, P=0.024)均可使发生ARC的危险性升高；而儿童期的影响因素只有10岁时的身高低于同龄儿童和体质量高于同龄儿童才与发生ARC危险性具有十分显著性关联(分别为 OR=1.329,95%CI：1.072~2.351,P=0.038；OR=2.302,95%CI：1.323~3.196,P=0.011)。<br> 结论：出生时胎龄越早、低体质量出生、母亲孕前糖尿病、孕期糖尿病、先兆子痫、妊娠期高血压、10岁时身高较矮,以及体质量升高均是ARC发病的危险因素。但需要进一步开展历时长、大规模的前瞻性研究,以证实我国人群ARC的早期危险因素。
目的：評價生命早期及兒童期影響因素與成人年齡相關性白內障( age-related cataract,ARC)髮病的關繫,為早期預防、早期髮現、早期治療ARC提供理論依據。<br> 方法：我院2011-04/2012-10開展以醫院為基礎的病例對照研究,病例由41~60歲的360例360眼施行白內障摘除術的患者所組成。對照組由與病例的年齡和性彆進行匹配、因罹患各種與ARC無關的疾病、同期入住相同醫院的360例非白內障的患者所組成。採用自製的調查問捲對所有研究對象進行調查,包括研究對象的一般狀況、生命早期影響因素,以及兒童期暴露因素。採用非條件Logistic迴歸模型對結果進行分析。<br> 結果：齣生時胎齡越早,齣生時體質量越低,均與髮生ARC的危險性具有顯著性關聯(分彆為 OR =1.152,95%CI：1.029~2.235, P=0.024；OR=1.374,95%CI：1.156~2.581,P=0.037)；母親孕前糖尿病( OR=1.587,95%CI：1.177~2.915,P =0.019)、孕期糖尿病(OR =1.763,95%CI：1.375~2.367,P =0.004)、先兆子癇( OR=1.581,95%CI：1.139~1.996,P=0.021),以及妊娠期高血壓(OR=1.517,95%CI：1.032~1.963, P=0.024)均可使髮生ARC的危險性升高；而兒童期的影響因素隻有10歲時的身高低于同齡兒童和體質量高于同齡兒童纔與髮生ARC危險性具有十分顯著性關聯(分彆為 OR=1.329,95%CI：1.072~2.351,P=0.038；OR=2.302,95%CI：1.323~3.196,P=0.011)。<br> 結論：齣生時胎齡越早、低體質量齣生、母親孕前糖尿病、孕期糖尿病、先兆子癇、妊娠期高血壓、10歲時身高較矮,以及體質量升高均是ARC髮病的危險因素。但需要進一步開展歷時長、大規模的前瞻性研究,以證實我國人群ARC的早期危險因素。
목적：평개생명조기급인동기영향인소여성인년령상관성백내장( age-related cataract,ARC)발병적관계,위조기예방、조기발현、조기치료ARC제공이론의거。<br> 방법：아원2011-04/2012-10개전이의원위기출적병례대조연구,병례유41~60세적360례360안시행백내장적제술적환자소조성。대조조유여병례적년령화성별진행필배、인리환각충여ARC무관적질병、동기입주상동의원적360례비백내장적환자소조성。채용자제적조사문권대소유연구대상진행조사,포괄연구대상적일반상황、생명조기영향인소,이급인동기폭로인소。채용비조건Logistic회귀모형대결과진행분석。<br> 결과：출생시태령월조,출생시체질량월저,균여발생ARC적위험성구유현저성관련(분별위 OR =1.152,95%CI：1.029~2.235, P=0.024；OR=1.374,95%CI：1.156~2.581,P=0.037)；모친잉전당뇨병( OR=1.587,95%CI：1.177~2.915,P =0.019)、잉기당뇨병(OR =1.763,95%CI：1.375~2.367,P =0.004)、선조자간( OR=1.581,95%CI：1.139~1.996,P=0.021),이급임신기고혈압(OR=1.517,95%CI：1.032~1.963, P=0.024)균가사발생ARC적위험성승고；이인동기적영향인소지유10세시적신고저우동령인동화체질량고우동령인동재여발생ARC위험성구유십분현저성관련(분별위 OR=1.329,95%CI：1.072~2.351,P=0.038；OR=2.302,95%CI：1.323~3.196,P=0.011)。<br> 결론：출생시태령월조、저체질량출생、모친잉전당뇨병、잉기당뇨병、선조자간、임신기고혈압、10세시신고교왜,이급체질량승고균시ARC발병적위험인소。단수요진일보개전력시장、대규모적전첨성연구,이증실아국인군ARC적조기위험인소。
?AlM: To evaluate the relationship of early-life and childhood exposures and age-related cataract ( ARC ) , and provide a scientific evidence for early preventing, treating and detecting ARC. <br> ?METHODS: A hospital-based case control study was conducted from April 2011 to October 2012. A total of 360 cases ( 360 eyes ) aged 41 ~ 60 years old for cataract extraction and 360 frequency-matched controls in the same hospital for various not related to ARC were included in the study. A structured interviewer -administrated questionnaire that included information on sociodemographic characteristics, early - life and childhood exposures was used. The risk factors of ARC were estimated with unconditioned logistic regression models. <br> ?RESULTS:Early gestational age at birth sooner and lower birth weight was significantly associated with the risk of ARC(OR=1. 152,95%CI:1. 029~2. 235,P=0. 024;OR=1. 374, 95%CI:1. 156 ~2. 581,P=0. 037,respectively). The maternal pre-pregnancy diabetes ( OR=1. 587, 95%CI:1. 177~2. 915,P=0. 019),gestational diabetes (OR=1. 763, 95%CI:1. 375 ~ 2. 367,P= 0. 004), preeclampsia(OR=1. 581, 95%CI: 1. 139 ~1. 996,P=0. 021), and pregnancy induced hypertension (OR=1. 517, 95%CI:1. 032~1. 963,P=0. 024) could make the risk of ARC increased. Of the factors affecting the period of children, only shorter height relative to peers and overweight at age 10 were significantly associated with the risk of ARC( OR=1. 329, 95%CI:1. 072~2. 351,P=0. 038;OR=2. 302, 95%CI:1. 323~3. 196,P=0. 011, respectively). <br> ?CONCLUSlON:Early gestational age at birth, low birth weight, the maternal pre - pregnancy diabetes, gestational diabetes, preeclampsia, and gestational hypertension, and shorter height and overweight relative to peers, at age 10 were risk factors of ARC. But lasted long large and prospective studies are needed to insure early risk factors for ARC in the Chinese population.
