CAJ | 학술논문

目的：分析研究大杯盘比( cup/disk, C/D)患者24h眼压、视野及电生理的变化情况。 　　方法：选择大C/D(C/D>0.3)患者120例240眼,并根据C/D大小将其分为两组：A组,0.3<C/D<0.6,67例114眼；B组,C/D≥0.6,73例126眼。选择正常对照组( C/D≤0.3)40例80眼。行24h眼压检查、30-2 SITA-标准静态阈值视野检查及图形视网膜电图检查( pattern electroretinogram, P-ERG)。比较分析三组患者上述检查指标的差异性。 　　结果：对于24 h眼压,三组患者眼压均值比较无显著统计学差异(P>0.05),波动幅度比较有显著统计学差异(P<0.05)；B组患者眼压波动幅度明显高于正常对照组,差异具有统计学意义(P<0.05)。对于静态阈值视野,三组患者平均偏差( mean deviation, MD)及图样标准差( pattern standard deviation, PSD )比较有显著统计学差异( P<0.05)；两两比较,与正常对照组相比, B 组患者 MD 及PSD明显增加,差异具有统计学意义(P<0.05),而A组则无显著统计学差异(P>0.05)；A,B 两组相比,B 组患者MD及 PSD 明显高于 A 组,差异具有统计学意义( P<0.05)。对于P-ERG检查,三组患者P50波潜伏期比较无显著统计学差异(P>0.05),波幅比较有显著统计学差异(P<0.05)；两两比较,与正常对照组相比,B 组患者P50波振幅明显降低,差异具有统计学意义(P<0.05),而A组则无显著统计学差异(P>0.05)；A,B两组相比,B组患者P50波振幅明显低于A组,差异具有统计学意义(P<0.05)。结论：当C/D≥0.6时,患者24h眼压监测、静态阈值视野检查及图形视网膜电流图P50波有明显改变。对于大杯盘比患者,仅行单次眼压检查是远远不够的,应予以详细视功能检查。同时,将C/D 0.6作为可疑青光眼的筛查标准是可行的。
목적：분석연구대배반비( cup/disk, C/D)환자24h안압、시야급전생리적변화정황。 　　방법：선택대C/D(C/D>0.3)환자120례240안,병근거C/D대소장기분위량조：A조,0.3<C/D<0.6,67례114안；B조,C/D≥0.6,73례126안。선택정상대조조( C/D≤0.3)40례80안。행24h안압검사、30-2 SITA-표준정태역치시야검사급도형시망막전도검사( pattern electroretinogram, P-ERG)。비교분석삼조환자상술검사지표적차이성。 　　결과：대우24 h안압,삼조환자안압균치비교무현저통계학차이(P>0.05),파동폭도비교유현저통계학차이(P<0.05)；B조환자안압파동폭도명현고우정상대조조,차이구유통계학의의(P<0.05)。대우정태역치시야,삼조환자평균편차( mean deviation, MD)급도양표준차( pattern standard deviation, PSD )비교유현저통계학차이( P<0.05)；량량비교,여정상대조조상비, B 조환자 MD 급PSD명현증가,차이구유통계학의의(P<0.05),이A조칙무현저통계학차이(P>0.05)；A,B 량조상비,B 조환자MD급 PSD 명현고우 A 조,차이구유통계학의의( P<0.05)。대우P-ERG검사,삼조환자P50파잠복기비교무현저통계학차이(P>0.05),파폭비교유현저통계학차이(P<0.05)；량량비교,여정상대조조상비,B 조환자P50파진폭명현강저,차이구유통계학의의(P<0.05),이A조칙무현저통계학차이(P>0.05)；A,B량조상비,B조환자P50파진폭명현저우A조,차이구유통계학의의(P<0.05)。결론：당C/D≥0.6시,환자24h안압감측、정태역치시야검사급도형시망막전류도P50파유명현개변。대우대배반비환자,부행단차안압검사시원원불구적,응여이상세시공능검사。동시,장C/D 0.6작위가의청광안적사사표준시가행적。
?AlM: To analyze and study the changes of intraocular pressure ( lOP) , visual field and P-ERG on patients with big cup/disk (C/D) in 24h. ?METHODS: A total of 120 cases ( 240 eyes ) diagnosed with big C/D (C/D>0. 3) were divided into group A (C/D<0. 6, 67 cases, 114 eyes ) and group B ( C/D≥0. 6, 73 cases, 126 eyes). Forty cases (80 eyes) with small C/D (C/D≤0. 3) were chosen as control group. All cases underwent 24h lOP examination, vision examination of 30-2 SlTA - standard static threshold and pattern electroretinogram ( P-ERG) examination. The differences between the examination indexes of the three groups were analyzed. ?RESULTS:There was no significant statistical difference in the 24h average lOP (P>0. 05) among the three groups, while the amplitudes had significant statistical differences (P<0. 05). Compared with the control group, the lOP amplitudes of group B were obviously higher, and the difference was of statistical significance (P<0. 05). ln terms of static threshold visual fields, the mean deviations (MD) and pattern standard deviations (PSD) of the three groups had significant statistical differences ( P < 0. 05 ). Comparison between every two groups:compared with the control group, the MD and the PSD were significantly increased in group B, and the difference was of statistical significance (P<0. 05); while there was no significant statistical difference in group A (P>0. 05);Compared with group A, the MD and the PSD were significantly higher in group B, and the difference was of statistical significance (P<0. 05). ln terms of P-ERG examination, there was no significant statistical difference in P50’s latent periods among the three groups (P>0. 05), but there were significant statistical differences in amplitudes (P<0. 05). Comparison between every two groups: compared with the control group, the P50’s amplitude was significantly decreased in group B, and the difference was of statistical significance (P<0. 05), while there was no significant statistical difference in group A (P>0. 05); Compared with group A, the P50’s amplitude of group B was significantly lower, and the difference was of statistical significance (P<0. 05). ?CONCLUSlON: When the patients’ C/D is no less than 0. 6, there are obvious changes of 24h lOP, static threshold visual field and P-ERG’s P50 wave. For patients with big C/D, a single lOP examination is far from sufficient, so an in-depth visual function examination should be performed. Meanwhile, it’s feasible to regard C/D 0. 6 as a screening criterion for suspected glaucoma.