中华危重病急救医学
中華危重病急救醫學
중화위중병급구의학
Chinese Critical Care Medicine
2015年
4期
259-262
,共4页
田甜%王永安%聂志勇%王姣%彭晓波%原野%李万华%邱泽武%薛艳萍%熊艺茹
田甜%王永安%聶誌勇%王姣%彭曉波%原野%李萬華%邱澤武%薛豔萍%熊藝茹
전첨%왕영안%섭지용%왕교%팽효파%원야%리만화%구택무%설염평%웅예여
铊%中毒%血液灌流%炭肾
鉈%中毒%血液灌流%炭腎
사%중독%혈액관류%탄신
Thallium%Poisoning%Hemoperfusion%Charcoal
目的:基于原子吸收法检测犬全血铊含量,观察血液灌流(HP)对血中铊的清除效能。方法经股动脉取未染毒比格犬的血液,根据实验动物体质量与血容量的换算公式,配制成3组浓度梯度的含硝酸亚铊(TlNO3)的犬血,充分模拟血液在体环境进行HP,以前一剂量组最后一次灌流结束后犬血中所含TlNO3的总量确定下一组含铊血液样品的配制。应用石墨炉原子吸收仪检测每次灌流前后犬全血铊含量,并对其进行统计分析。结果犬全血铊含量在0~200μg/L线性良好,相关系数为0.9984;日内精密度<4.913%,日内回收率96.2%~111.9%;日间精密度<7.502%,日间回收率89.6%~105.2%。高、中、低剂量组每次灌流后血铊浓度均明显降低〔高剂量组从(453.43±27.80)mg/L降至(56.09±14.44)mg/L,F=8.820,P=0.003;中剂量组从(64.51±13.60)mg/L降至(3.19±0.23)mg/L,F=36.312,P=0.000;低剂量组从(5.40±0.98)mg/L降至(0.38±0.25)mg/L,F=46.240,P=0.000〕。高、中、低剂量组4次灌流后总体吸附率分别为(87.63±2.48)%、(95.06±1.54)%、(92.76±4.87)%,组间比较差异无统计学意义(F=4.231,P=0.070)。结论采用石墨炉原子吸收仪检测血铊浓度定量准确、灵敏度高、稳定性强,所测样品处理简单,保存时间长,适合批量样本的检测。HP可以稳定、高效地清除血中的铊,4次灌流即可吸附90%以上的铊;且HP的吸附效率与血铊含量无关,即使血铊含量低,HP也是有效的。
目的:基于原子吸收法檢測犬全血鉈含量,觀察血液灌流(HP)對血中鉈的清除效能。方法經股動脈取未染毒比格犬的血液,根據實驗動物體質量與血容量的換算公式,配製成3組濃度梯度的含硝痠亞鉈(TlNO3)的犬血,充分模擬血液在體環境進行HP,以前一劑量組最後一次灌流結束後犬血中所含TlNO3的總量確定下一組含鉈血液樣品的配製。應用石墨爐原子吸收儀檢測每次灌流前後犬全血鉈含量,併對其進行統計分析。結果犬全血鉈含量在0~200μg/L線性良好,相關繫數為0.9984;日內精密度<4.913%,日內迴收率96.2%~111.9%;日間精密度<7.502%,日間迴收率89.6%~105.2%。高、中、低劑量組每次灌流後血鉈濃度均明顯降低〔高劑量組從(453.43±27.80)mg/L降至(56.09±14.44)mg/L,F=8.820,P=0.003;中劑量組從(64.51±13.60)mg/L降至(3.19±0.23)mg/L,F=36.312,P=0.000;低劑量組從(5.40±0.98)mg/L降至(0.38±0.25)mg/L,F=46.240,P=0.000〕。高、中、低劑量組4次灌流後總體吸附率分彆為(87.63±2.48)%、(95.06±1.54)%、(92.76±4.87)%,組間比較差異無統計學意義(F=4.231,P=0.070)。結論採用石墨爐原子吸收儀檢測血鉈濃度定量準確、靈敏度高、穩定性彊,所測樣品處理簡單,保存時間長,適閤批量樣本的檢測。HP可以穩定、高效地清除血中的鉈,4次灌流即可吸附90%以上的鉈;且HP的吸附效率與血鉈含量無關,即使血鉈含量低,HP也是有效的。
목적:기우원자흡수법검측견전혈사함량,관찰혈액관류(HP)대혈중사적청제효능。방법경고동맥취미염독비격견적혈액,근거실험동물체질량여혈용량적환산공식,배제성3조농도제도적함초산아사(TlNO3)적견혈,충분모의혈액재체배경진행HP,이전일제량조최후일차관류결속후견혈중소함TlNO3적총량학정하일조함사혈액양품적배제。응용석묵로원자흡수의검측매차관류전후견전혈사함량,병대기진행통계분석。결과견전혈사함량재0~200μg/L선성량호,상관계수위0.9984;일내정밀도<4.913%,일내회수솔96.2%~111.9%;일간정밀도<7.502%,일간회수솔89.6%~105.2%。고、중、저제량조매차관류후혈사농도균명현강저〔고제량조종(453.43±27.80)mg/L강지(56.09±14.44)mg/L,F=8.820,P=0.003;중제량조종(64.51±13.60)mg/L강지(3.19±0.23)mg/L,F=36.312,P=0.000;저제량조종(5.40±0.98)mg/L강지(0.38±0.25)mg/L,F=46.240,P=0.000〕。고、중、저제량조4차관류후총체흡부솔분별위(87.63±2.48)%、(95.06±1.54)%、(92.76±4.87)%,조간비교차이무통계학의의(F=4.231,P=0.070)。결론채용석묵로원자흡수의검측혈사농도정량준학、령민도고、은정성강,소측양품처리간단,보존시간장,괄합비량양본적검측。HP가이은정、고효지청제혈중적사,4차관류즉가흡부90%이상적사;차HP적흡부효솔여혈사함량무관,즉사혈사함량저,HP야시유효적。
ObjectiveTo determine thallium in whole blood by atomic absorption detection method, and to investigate the eliminating effect of hemoperfusion (HP) for thallium in blood.Methods The blood of Beagle dogs which had not exposed to thallium before were obtained for preparation of thallium nitrate (TlNO3)-containing solution in three concentrations according to the conversion formula based on animal weight and volume of blood. HP was performed in the simulated in vivo environment. The content of TlNO3 in blood of the next group was determined on the amount of TlNO3 for the last HP of the former dose group. Thallium quantity in different samples was measured with atomic absorption spectrometer blood samples before and after HP. Finally, the thallium concentration in blood was analyzed statistically.Results Thallium concentrations showed a good linear relationship in the range of 0-200μg/L (r = 0.998 4). The intra-day precision (RSD) was lower than 4.913%, the intra-day recovery rate was 96.2%-111.9%; the inter-day precision (RSD) was lower than 7.502%, the inter-day recovery rate was 89.6%-105.2%. The concentration of thallium in blood was significantly reduced after HP per time in high, middle, and low dose groups [(453.43±27.80) mg/L to (56.09±14.44) mg/L in high dose group,F = 8.820,P = 0.003;(64.51±13.60) mg/L to (3.19±0.23) mg/L in middle dose group,F = 36.312,P = 0.000; (5.40±0.98) mg/L to (0.38±0.25) mg/L in low dose group,F = 46.240,P = 0.000]. The adsorption rate of four times of HP in high, middle and low dose group were (87.63±2.48)%, (95.06±1.54)% and (92.76±4.87)%, respectively, without significant difference (F = 4.231,P = 0.070 ).Conclusions The method for measuring thallium was established, and it shows a very stable, simple, sensitive for determination of thallium. HP can effectively remove thallium from blood. Thallium concentration can be reduced by 90% after four times of HP. HP is also effective even when thallium concentration is not high.