CAJ | 학술논문

激素性股骨头坏死（ SONFH）是指因大剂量或长期应用糖皮质激素而造成股骨头活性成分死亡所引起的病理过程。SONFH的发生与血液凝溶系统组分、药物代谢酶与转运体、脂类代谢蛋白、血管内皮生长因子等基因及其多态性位点有关。开展SONFH相关基因多态性研究为探讨该病的发病机制、进行早期预防及实施个体化治疗提供了依据，但限于民族、地域、检测方法等存在差异，且SONFH病例及其对照者（服用激素未发生骨坏死）收集困难，有些结论还不尽一致，仍需进一步大样本、多中心、标准化的研究加以检验确证。
격소성고골두배사（ SONFH）시지인대제량혹장기응용당피질격소이조성고골두활성성분사망소인기적병리과정。SONFH적발생여혈액응용계통조분、약물대사매여전운체、지류대사단백、혈관내피생장인자등기인급기다태성위점유관。개전SONFH상관기인다태성연구위탐토해병적발병궤제、진행조기예방급실시개체화치료제공료의거，단한우민족、지역、검측방법등존재차이，차SONFH병례급기대조자（복용격소미발생골배사）수집곤난，유사결론환불진일치，잉수진일보대양본、다중심、표준화적연구가이검험학증。
Steroid-induced osteonecrosis of femoral head( SONFH)is the pathological process of the active ingredient of the femoral head death caused by the high-dose or long-term use of glucocorticoids. The SONFH is associated with gene polymorphisms included blood coagulation system components, drug metabolizing enzymes and transporters,lipid metabolism proteins,vascular endothelial growth factor gene. The researches of SONFH-related gene polymorphisms provide the basis of investigation of disease'pathogenesis, early prevention, and implementation of individualized treatment. However, due to the differences in national,regional,and testing methods and the difficulties in collecting cases of SONFH and control group which did not develop osteonecrosis after using hormone,some findings are inconsistent and the further large sample,multi-center,standardized tests still needed to confirm.