CAJ | 학술논문

1例45岁男性患者行左侧颌面部和颈部肿物切除术，术前丙氨酸转氨酶（ ALT）19 U／L，天冬氨酸转氨酶（AST）32 U／L，γ-谷氨酰转移酶（GGT）146 U／L。术后给予盐酸丙帕他莫2.0 g入0.9％氯化钠注射液100 ml静脉滴注，1次／12 h。术后第8天复查肝功能示ALT 642 U／L，AST 692 U／L， GGT 368 U／L。患者无恶心、呕吐、腹胀、纳差等不适症状，皮肤、巩膜无黄染，肝区无压痛。考虑为盐酸丙帕他莫所致急性肝损伤。当日停用盐酸丙帕他莫，给予多烯磷脂酰胆碱、还原型谷胱甘肽、N-乙酰半胱氨酸等保肝治疗。停用盐酸丙帕他莫第8天，ALT 87 U／L，AST 341 U／L，GGT 354 U／L；第18天，ALT 84 U／L，AST 36 U／L，GGT 276 U／L；第32天，ALT 24 U／L，AST 17 U／L，GGT 36 U／L。
1례45세남성환자행좌측합면부화경부종물절제술，술전병안산전안매（ ALT）19 U／L，천동안산전안매（AST）32 U／L，γ-곡안선전이매（GGT）146 U／L。술후급여염산병파타막2.0 g입0.9％록화납주사액100 ml정맥적주，1차／12 h。술후제8천복사간공능시ALT 642 U／L，AST 692 U／L， GGT 368 U／L。환자무악심、구토、복창、납차등불괄증상，피부、공막무황염，간구무압통。고필위염산병파타막소치급성간손상。당일정용염산병파타막，급여다희린지선담감、환원형곡광감태、N-을선반광안산등보간치료。정용염산병파타막제8천，ALT 87 U／L，AST 341 U／L，GGT 354 U／L；제18천，ALT 84 U／L，AST 36 U／L，GGT 276 U／L；제32천，ALT 24 U／L，AST 17 U／L，GGT 36 U／L。
A 45-year-old male received a lump resection on left maxillofacial and cervical region. Before treatment,the laboratory test results were as follows:alanine aminotransferase( ALT)19 U/L, aspartate aminotransferase( AST)32 U/L,gamma glutamyltransferase( GGT)146 U/L. He was given an intravenous infusion of propacetamol hydrochloride 2. 0 g in 0. 9% sodium chloride 100 ml twice daily. The laboratory tests were as follows:alanine aminotransferase 642 U/L,aspartate aminotransferase 692 U/L, gamma glutamyltransferase 368 U/L on day 8 after operation. The patient had no symptoms of nausea, vomiting,abdominal distention,and poor appetite. There was no tenderness in his hepatic zones. He was considered as acute liver injury due to propacetamol hydrochloride. Propacetamol hydrochloride was discontinued immediately and liver-protective drugs such as polyene phosphatidylcholine, reduced glutathione,and N-acetyl cysteine were given. On day 8 of drug withdrawal,the results of laboratory tests were as follows:ALT 87 U/L,AST 341 U/L,GGT 354 U/L. On day 32 of drug withdrawal,the laboratory tests results were as follows:ALT 24 U/L,AST 17 U/L,GGT 36 U/L.