CAJ | 학술논문

目的：比较兰地洛尔和艾司洛尔的抗心律失常作用和安全性。方法用序贯法测定兰地洛尔和艾司洛尔的半数致死量（ LD50）、半数有效量（ ED50），计算其治疗指数。用多种心律失常模型，观察比较兰地洛尔和艾司洛尔在等效剂量下的抗心律失常作用。结果兰地洛尔和艾司洛尔的ED50、LD50值分别为14.4，347.0 mg? kg-1和17.3，100.0 mg? kg-1，两药的治疗指数分别为24.1和5.8。兰地洛尔和艾司洛尔抗氯仿诱导的小鼠心律失常作用的等效剂量比为0.83∶1。两药对多种心律失常模型均有相似的抗心律失常作用，但艾司洛尔减慢心率的作用较强，而兰地洛尔的作用相对平缓。结论与艾司洛尔相比，等效剂量下的兰地洛尔具有相似的抗心律失常作用，起效更快，减慢心率作用更平缓，且治疗指数更高，更加安全。
목적：비교란지락이화애사락이적항심률실상작용화안전성。방법용서관법측정란지락이화애사락이적반수치사량（ LD50）、반수유효량（ ED50），계산기치료지수。용다충심률실상모형，관찰비교란지락이화애사락이재등효제량하적항심률실상작용。결과란지락이화애사락이적ED50、LD50치분별위14.4，347.0 mg? kg-1화17.3，100.0 mg? kg-1，량약적치료지수분별위24.1화5.8。란지락이화애사락이항록방유도적소서심률실상작용적등효제량비위0.83∶1。량약대다충심률실상모형균유상사적항심률실상작용，단애사락이감만심솔적작용교강，이란지락이적작용상대평완。결론여애사락이상비，등효제량하적란지락이구유상사적항심률실상작용，기효경쾌，감만심솔작용경평완，차치료지수경고，경가안전。
Objective To compare the antiarrhythmic effects and safety of landiolol and esmolol .Methods The sequential method was used to detect the median lethal dose ( LD50 ) and 50%effective dose ( ED50 ) of the two drugs.Treatment index were calculated by LD 50/ED50 .Several of arrhythmia models were used to study the antiarrhythmic effects of landio-lol and esmolol in the equivalent dose .Results ED50 and LD50 of landio-lol and esmolol were 14.4 , 17.3 mg? kg -1 and 347 , 100 mg? kg -1 re-spectively , TI were 24.1 and 5.8.The ratio of equivalent dose between landiolol and esmolol on anti -chloroform induced arrhythmia was 0.83∶1.Landiolol and esmolol have similar anti -arrythmia effect on va-rious arrhythmia models.Esmolol has a stronger inhibition function on the heart rate than that of landiolol .Conclusion Compared with esmolol , landiolol has similar antiarrhythmic effect , gentle and slow effect on heart rate, higher treatment index and safety in equivalent dose .