CAJ | 학술논문

目的：研究脾多肽注射液在食管癌患者辅助治疗的作用。方法：选择2010年10月至2014年10月间住院治疗的60例食管癌患者。随机分为观察组(在放、化疗同时联合应用脾多肽注射液)30例和对照组(单纯放化疗)30例。化疗患者均采用PF方案化疗（顺铂20mg/m2，静脉滴注1h，第1～5天；氟尿嘧啶500mg/m2，持续静脉注射24h，第1～5天；21d为1个周期）。放疗患者：放射剂量60～70Gy/30～35f/6～7w。化疗两周期或放疗结束后评价近期疗效、毒副作用、生活质量。结果：两组近期疗效相当，在胃肠道反应和肝肾功能损害方面两组无显著差异，但在骨髓抑制的发生率观察组明显低于对照组(P＜0.05)，观察组患者的生活质量也优于对照组，差异有统计学意义(P＜0.05)。结论：脾多肽能明显减轻食管癌放化疗患者的骨髓抑制等毒副反应，减少放化疗中可能导致治疗中断的不良因素，明显提高放、化疗患者的生活质量，值得应用推广。
목적：연구비다태주사액재식관암환자보조치료적작용。방법：선택2010년10월지2014년10월간주원치료적60례식관암환자。수궤분위관찰조(재방、화료동시연합응용비다태주사액)30례화대조조(단순방화료)30례。화료환자균채용PF방안화료（순박20mg/m2，정맥적주1h，제1～5천；불뇨밀정500mg/m2，지속정맥주사24h，제1～5천；21d위1개주기）。방료환자：방사제량60～70Gy/30～35f/6～7w。화료량주기혹방료결속후평개근기료효、독부작용、생활질량。결과：량조근기료효상당，재위장도반응화간신공능손해방면량조무현저차이，단재골수억제적발생솔관찰조명현저우대조조(P＜0.05)，관찰조환자적생활질량야우우대조조，차이유통계학의의(P＜0.05)。결론：비다태능명현감경식관암방화료환자적골수억제등독부반응，감소방화료중가능도치치료중단적불량인소，명현제고방、화료환자적생활질량，치득응용추엄。
ObjectiveResearch on spleen polypeptide injection the role of adjuvant therapy in patients with esophageal cancer.Methods Choose between October 2014 to October 2010 in treatment of 60 patients with esophageal cancer hospital. 30 cases were randomly divided into observation group and control group 30 cases.ResultsTwo groups of curative effect quite recently, in the aspect of gastrointestinal reaction and function of liver and kidney damage in the two groups had no significant difference, but in the incidence of bone marrow suppression group observation was lower than that in control group (P < 0.05), the observation group of patients quality of life is better than control group, the difference was statistically significant (P < 0.05).Conclusions Spleen polypeptides can significantly reduce esophageal radiation and chemotherapy in patients with adverse reactions such as bone marrow suppression, reduce the radiation and chemotherapy in treatment may lead to interruption of adverse factors, significantly improve the life quality of patients with radiation and chemotherapy, is worth popularizing application.