CAJ | 학술논문

目的：分析抗肿瘤药物引起严重不良反应的发生特点和一般规律。方法收集用抗肿瘤药物引起的365例严重不良反应，从年龄、性别、药物分类和发生严重不良反应关系、严重不良反应累及器官／系统及主要临床表现等方面进行统计分析。结果365例严重不良反应中有210例用静脉滴注给药，男性略多于女性，平均年龄54.57岁，以中老年患者（≥50岁）居多。严重不良反应的临床表现以血液系统、皮肤黏膜和消化系统的损害最为多见。在患者转归方面，好转和痊愈共占76.71％。结论抗肿瘤药物引起的严重不良反应和年龄、剂型、给药途径相关，防治方面要充分发挥专科临床药师的作用，对抗肿瘤药物引起的不良反应进行集中监测报告，预防或减少严重不良反应的发生。
목적：분석항종류약물인기엄중불량반응적발생특점화일반규률。방법수집용항종류약물인기적365례엄중불량반응，종년령、성별、약물분류화발생엄중불량반응관계、엄중불량반응루급기관／계통급주요림상표현등방면진행통계분석。결과365례엄중불량반응중유210례용정맥적주급약，남성략다우녀성，평균년령54.57세，이중노년환자（≥50세）거다。엄중불량반응적림상표현이혈액계통、피부점막화소화계통적손해최위다견。재환자전귀방면，호전화전유공점76.71％。결론항종류약물인기적엄중불량반응화년령、제형、급약도경상관，방치방면요충분발휘전과림상약사적작용，대항종류약물인기적불량반응진행집중감측보고，예방혹감소엄중불량반응적발생。
Objective To analyze the characteristics and patterns of occurrence of the serious adverse drug reaction ( ADR) induced by anti-cancer drugs.Methods From a total of 365 serious ADR cases collec-ted from January 2010 to August 2012 in Beijing Adverse Drug Reaction Center , statistical analysis was carried out from the age , sex , drug classi-fication and severe ADR relationship , severe ADR involved organ/system and main clinical manifestations , and so on.Results There were 210 patients out of 365 cases of severe ADR received intravenous infusion , slightly higher in males than females .The average age was 54.57 years old, and most of them were middle -aged and elderly patients (≥50 years old ) .The clinical manifestations of severe adverse reactions were most common in hematological system , skin mucous membrane and diges-tive system damages .In patient outcomes , improved and recovered pa-tients accounted for 76.71%.Conclusion The serious ADR induced by anticancer drugs is related with age , dosage form and route of administra-tion.The special clinical pharmacists play an important role in prevention and cure , who should monitor and report centrally ADR caused by anti-cancer drugs , and prevent or reduce the occurrence of serious ADR .