中国性科学
中國性科學
중국성과학
THE CHINESE JOURNAL OF HUMAN SEXUALITY
2015年
4期
8-10
,共3页
帕瑞昔布钠%宫颈癌根治术%术后镇痛%TNF -α%IL -6%IL -8
帕瑞昔佈鈉%宮頸癌根治術%術後鎮痛%TNF -α%IL -6%IL -8
파서석포납%궁경암근치술%술후진통%TNF -α%IL -6%IL -8
Parecoxib Sodium%Radical operation of cervical carcinoma%Analgesia%TNF -α%IL-6%IL -8
目的：探讨帕瑞昔布钠对宫颈癌根治术患者术后镇痛的影响。方法：80例行宫颈癌根治术患者，随机将其分为观察组和对照组，各40例。观察组在麻醉诱导后静脉注射帕瑞昔布钠。对照组输注生理盐水。结果：术后6h、12h，观察组咳嗽、安静痛 VAS 评分低于对照组咳嗽、安静痛 VAS 评分，差异具有统计学意义（P ＜0.05）。术毕、术后12h、24h，观察组的 IL －6、TNF －α浓度低于对照组 IL －6、TNF －α浓度，差异具有统计学意义（P ＜0.05）。术后12h、24h，观察组 IL －8浓度低于对照组 IL －8浓度，差异具有统计学意义（P ＜0.01）。观察组舒芬太尼用量少于对照组舒芬太尼用量，差异具有统计学意义（P ＜0.01）。术后24h，观察组恶心、嗜睡、呕吐人数少于对照组，下床人数多于对照组，差异具有统计学意义（P ＜0.01）。结论：帕瑞昔布钠能够减少行宫颈癌根治术患者舒芬太尼的用量，提高镇痛效果，降低炎性因子水平，减少患者不良反应，利于患者术后康复。
目的：探討帕瑞昔佈鈉對宮頸癌根治術患者術後鎮痛的影響。方法：80例行宮頸癌根治術患者，隨機將其分為觀察組和對照組，各40例。觀察組在痳醉誘導後靜脈註射帕瑞昔佈鈉。對照組輸註生理鹽水。結果：術後6h、12h，觀察組咳嗽、安靜痛 VAS 評分低于對照組咳嗽、安靜痛 VAS 評分，差異具有統計學意義（P ＜0.05）。術畢、術後12h、24h，觀察組的 IL －6、TNF －α濃度低于對照組 IL －6、TNF －α濃度，差異具有統計學意義（P ＜0.05）。術後12h、24h，觀察組 IL －8濃度低于對照組 IL －8濃度，差異具有統計學意義（P ＜0.01）。觀察組舒芬太尼用量少于對照組舒芬太尼用量，差異具有統計學意義（P ＜0.01）。術後24h，觀察組噁心、嗜睡、嘔吐人數少于對照組，下床人數多于對照組，差異具有統計學意義（P ＜0.01）。結論：帕瑞昔佈鈉能夠減少行宮頸癌根治術患者舒芬太尼的用量，提高鎮痛效果，降低炎性因子水平，減少患者不良反應，利于患者術後康複。
목적：탐토파서석포납대궁경암근치술환자술후진통적영향。방법：80례행궁경암근치술환자，수궤장기분위관찰조화대조조，각40례。관찰조재마취유도후정맥주사파서석포납。대조조수주생리염수。결과：술후6h、12h，관찰조해수、안정통 VAS 평분저우대조조해수、안정통 VAS 평분，차이구유통계학의의（P ＜0.05）。술필、술후12h、24h，관찰조적 IL －6、TNF －α농도저우대조조 IL －6、TNF －α농도，차이구유통계학의의（P ＜0.05）。술후12h、24h，관찰조 IL －8농도저우대조조 IL －8농도，차이구유통계학의의（P ＜0.01）。관찰조서분태니용량소우대조조서분태니용량，차이구유통계학의의（P ＜0.01）。술후24h，관찰조악심、기수、구토인수소우대조조，하상인수다우대조조，차이구유통계학의의（P ＜0.01）。결론：파서석포납능구감소행궁경암근치술환자서분태니적용량，제고진통효과，강저염성인자수평，감소환자불량반응，리우환자술후강복。
Objectives:To study of the pain intervention effect of Parecoxib Sodium on patients with cervi-cal cancer radical operation.Methods:80 cases of cervical cancer radical operation patients were randomly divided into control group and observation group,40 cases in each group.Control group was given saline infusion.The ob-servation group was given intravenous injection of parecoxib sodium after induction of anesthesia.Results:After the operation 6h and 12h,the cough and quiet VAS pain scores of the observation group were less than these of the con-trol group,with statistically significant difference (P <0.05).After the operation and 12h and 24h after the opera-tion,IL -6 and TNF -αlevel of the observation group were less than these in the control group,with statistically significant difference (P <0.05).12h and 24h after the operation,IL -8 concentration of the observation group was less than that in the control group,with statistically significant difference (P <0.01).The dose of morphine used in the observation group was less than it used in the control group,with statistically significant difference (P <0.01).24h after the operation the number of nausea,lethargy and vomiting in the observation group were less than these in the control group.The number of patients who got out of bed in the observation group was more than that in the control group,with statistically significant difference (P <0.01).Conclusion:Parecoxib Sodium can reduce the dose of morphine in patients with cervical cancer radical operation,enhance the analgesic effect,reduce the lev-el of inflammatory factors,reduce adverse reaction and help the rehabilitation of the patients after operation.
